[23 Oct 2014 | ]
Polydispersity – what does it mean for DLS and chromatography?

The term polydispersity (or more recently dispersity without the poly, as per IUPAC recommendation) is used to describe the degree of “non-uniformity” of a distribution.  In the field of molecular/nanoparticular characterization there are in principle two different definitions of polydispersity, depending on the underlying property of interest. In gel permeation chromatography (GPC) and size exclusion [...]

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Dynamic Light Scattering, Molecular size, Molecular weight, Size Exclusion Chromatography, Static Light Scattering, Tech Talk, Viscotek range, Zetasizer range »

[23 Oct 2014 | ]
Polydispersity – what does it mean for DLS and chromatography?

The term polydispersity (or more recently dispersity without the poly, as per IUPAC recommendation) is used to describe the degree of “non-uniformity” of a distribution.  In the field of molecular/nanoparticular characterization there are in principle two different definitions of polydispersity, depending on the underlying property of interest. In gel permeation chromatography (GPC) and size exclusion [...]

Read the full story »

Customer experience, Differential Scanning Calorimetry, Isothermal Titration Calorimetry, MicroCal range, Microcalorimetry, Tech Talk »

[21 Oct 2014 | ]
Synthetic gankyrin binding proteins herald progress in cancer fight

Over production of certain proteins that control cellular responses in the body can lead to unregulated events, including various cancers.  Proteins linked to tumor growth, known as oncoproteins, can be extremely difficult to inhibit by known small molecule drugs, owing to their relatively featureless binding surfaces, which lack well-defined small molecules. A sub-set of these [...]

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Dynamic Light Scattering, Molecular size, Protein Aggregation, Tech Talk, Zetasizer range »

[14 Oct 2014 | ]
Is there an Autosampler for the Zetasizer?

There is one, and it is called the NanoSampler. The Zetasizer has been around for a few years, and the Zetasizer series now includes several models (90 degrees, backscattering, size and zeta, flowmode for chromatography detection, automated plate sampler). A very recent accessory which is compatible with any Zetasizer Nano in the field is the autosampler [...]

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Molecular structure, Molecular weight, Size Exclusion Chromatography, Tech Talk, Viscotek range »

[10 Oct 2014 | ]
Benefits of tetra detection for SEC analysis of membrane proteins revealed!

As a Product Technical Specialist at Malvern Instruments a great part of my job is talking to customers and finding out how they are utilizing our instruments to perform new and exciting research. My role focuses on the use of Size Exclusion Chromatography (SEC) to analyze biopolymers and proteins. Following on from my recent blog [...]

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