[20 Jul 2017 | ]
Solving structure from powder XRD data

As communicated last year, as of 1 January 2017 Malvern Instruments and PANalytical have merged their activities. Both companies are owned by parent company Spectris plc and are world leading suppliers of analytical instrumentation, PANalytical for X-ray instrumentation and software for the purpose of materials analysis, and Malvern Instruments for materials and biophysical characterization technology.
PANalytical’s main technologies are X-ray fluorescence (XRF) and X-ray diffraction (XRD) which provide elemental and structural information on a range of materials across different industry segments and application areas. One such application is solving and understanding crystal structure in crystalline …

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[20 Jul 2017 | ]
Solving structure from powder XRD data

As communicated last year, as of 1 January 2017 Malvern Instruments and PANalytical have merged their activities. Both companies are owned by parent company Spectris plc and are world leading suppliers of analytical instrumentation, PANalytical for X-ray instrumentation and software for the purpose of materials analysis, and Malvern Instruments for materials and biophysical characterization technology.
PANalytical’s main technologies are X-ray fluorescence (XRF) and X-ray diffraction (XRD) which provide elemental and structural information on a range of materials across different industry segments and application areas. One such application is solving and understanding crystal structure in crystalline …

Read the full story »

Differential Scanning Calorimetry, Dynamic Light Scattering, Meet the Experts, MicroCal, Molecular size, Molecular weight, OMNISEC, Particle concentration, Protein Aggregation, Size Exclusion Chromatography, Taylor Dispersion Analysis, Zetasizer »

[18 Jul 2017 | ]
Impact of Freeze -Thaw on monoclonal Antibody solutions

Monoclonal Antibodies – or mAbs for short

Since many of these mAbs require refrigeration we had used dynamic light scattering (with a Zetasizer) to show the formation of aggregates after freeze-thaw cycles (for details see application note “Effect of storage conditions on Immunoglobulin“). These could be seen both in the increased polydispersity index (PDI) and the appearance of a large-size aggregate peak in the intensity size distribution as shown to the right. The area under the peak gives an indication of the presence of the large aggregates but is not suited for …

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[13 Jul 2017 | ]
Malvern’s Top Content Q2 2017

Top Content
Once again, I prepared our latest top content materials from beginner’s guides to advanced education.
Malvern’s content is available in a variety of formats, and to help explain what these different formats are, we have compiled a quick guide to our key content types, together with a link to the most popular so far in 2017:
 
Application Notes
Describes a customer issue/problem and how it can be resolved with the appropriate Malvern solution.

Basic principles of particle size analysis
Using the Morphologi G3 to evaluate ceramic granules produced by spray drying
Number and volume size …

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Dynamic Light Scattering, Tech Talk, Zetasizer »

[11 Jul 2017 | ]
DLS in 30 Minutes – Q&A

A webinar entitled “DLS in 30 Minutes” was given in June which attracted a very large audience. The presentation introduced dynamic light scattering and covered the principles of the technique, a discussion of how the measurement is performed, how the data is analyzed and how the results obtained should be interpreted.
We were inundated with various questions during the webinar and we only had time to answer a few on the day. The remainder of questions were answered via e-mail but we thought it would be good to share some of …

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