[25 Aug 2016 | ]
D90, D50, D10, and span – for DLS?

Size distributions are a description of the fact that not every component in the sample has the same size.  There is a range of sizes present, as mathematically described by a distribution.
 
 
 
There are different ways to represent this distribution in terms of:

Intensity – How much light comes from the different components?
Volume or mass – How much volume is present in the different components?
Number – How many particles are present in the different components?

This often causes confusion, and the intensity volume number issue is one of the most popular blogs.
Intuitively most …

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Browse Categories

Dynamic Light Scattering, Laser Diffraction, Mastersizer, Particle size, Tech Talk, Zetasizer »

[25 Aug 2016 | ]
D90, D50, D10, and span – for DLS?

Size distributions are a description of the fact that not every component in the sample has the same size.  There is a range of sizes present, as mathematically described by a distribution.
 
 
 
There are different ways to represent this distribution in terms of:

Intensity – How much light comes from the different components?
Volume or mass – How much volume is present in the different components?
Number – How many particles are present in the different components?

This often causes confusion, and the intensity volume number issue is one of the most popular blogs.
Intuitively most …

Read the full story »

Binding affinity and Kd, Differential Scanning Calorimetry, Isothermal Titration Calorimetry, Label-free analysis, Malvern Events, MicroCal, Microcalorimetry, Protein higher order structure »

[23 Aug 2016 | ]
MicroCal User Days in San Diego and Cambridge MA in October 2016: Register Now

Malvern Instruments is sponsoring two “MicroCal User Days” in October:

Tuesday October 18 2016: West Coast MicroCal User Day in San Diego, CA

 

Thursday October 27 2016: New England MicroCal User Day in Cambridge, MA

 
Each of the User Days features talks by scientists in academia and industry, showing how Isothermal Titration Calorimetry (ITC) and/or Differential Scanning Calorimetry (DSC) provide solutions to advance their research or drug discovery efforts.  See the webpage for each event for more details on location and timing, and to review the list of invited speakers.
These User Days provide opportunities …

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Inside Malvern »

[18 Aug 2016 | ]
Malvern Instruments Internships

Malvern Instruments Internships
UK Helpdesk internship experience for a German Student
‘Courage is not the absence of fear, but rather the judgement that something else is more important than fear.’
-Ambrose Redmoon
My name is Tamara Hamberger and I decided to fly to England, because to get my EBBD-certificate (European Business Baccalaureate Diploma), I need to have an internship abroad for at least four weeks. And I wanted to go to a country where the main language is English. And so I applied for an internship with Principia School of Language, and they have …

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Dynamic Light Scattering, Molecular size, Particle size, Tech Talk, Zetasizer »

[16 Aug 2016 | ]
Why does DLS say that my particles are too small?

Why are my particles measuring too small?
The technique of  Dynamic Light Scattering (DLS) has become quite standard in many biophysical characterization labs, often alongside common tools like UV-Vis, SEC, AUC, Fluorescence, NMR, AFM, SAXS, or Mass Spec.  As DLS systems (like the Malvern Zetasizer Nano) have become ever easier to use we see an increasing range of applications and research. By observing and analyzing intensity fluctuations in a sample, we can find the diffusion coefficient and, with known viscosity, the corresponding size. Inevitably, at some point the size measured will not …

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