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Customer Spotlight: Collaborating for safer biopharmaceuticals

1 June 2017 No Comment

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Our key driver at Malvern Instruments is to create technologies that make a difference or solve a problem, and working hand-in-hand with our customers enables us to make sure that’s exactly what’s happening, out in the field.  We place a high value on our collaborations and partnerships with customers from a wide range of industries and organizations across the globe and love to see how our systems are being used in real-world scenarios.  This gives us vital feedback on what we’re doing well, and also any tweaks we need to make in order to optimize our technologies.

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One of our closest collaborations is with John Carpenter, Professor of Pharmaceutical Sciences at the University of Colorado, Anschutz Medical Campus.  John’s laboratory works on understanding and finding ways of controlling aggregates and other particles in biopharmaceutical products which may affect product quality, efficacy, and even safety.  As investment in the development and manufacture of protein-based therapeutics continues to surge worldwide, it is vital that this is supported by efforts to further understanding and optimization of their biophysical properties.  John’s team aims to evaluate new analytical technologies – including those developed by Malvern Instruments – that can offer insight in this area.

Within the Carpenter lab, there is currently a range of Malvern technologies, including NanoSight, MicroCal, Morphologi, Archimedes and Viscotek instruments, which have together enabled the team to make significant advances in characterizing particles, especially those in the subvisible range, in protein drug delivery systems.  One of the challenges, and also the success stories, of this collaboration has been the group’s growing understanding of how to use these techniques together, in a complementary and sometimes orthogonal way, to develop a full biophysical picture of a product.

“We have been fortunate to have a long-term collaboration with Malvern Instruments, in which we work together on the applications of state-of-the-art instruments and also the development of guidance for best practice for the characterization of therapeutic protein samples. We benefit from this relationship, not only because of access to the newest and best instruments, but also because of the expert guidance and advice we receive from our Malvern collaborators. And we have a lot of fun working together!”

John Carpenter, Professor of Pharmaceutical Sciences in the Department of Pharmaceutical Sciences at the University of Colorado, Anschutz Medical Campus

To read the whole story, please head over to the University of Colorado – Customer Story, and get more of the details of John’s work.  And if you’re interested in partnering with Malvern in the future, or have a good story about how you use your Malvern technologies, please do not hesitate to get in touch!

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