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Mark Pothecary
Mark Pothecary studied biochemistry while an undergraduate at the University of Bath before moving to London to obtain his Masters and PhD at the academic lab in the William Harvey Research Institute, part of the Queen Mary University between 2002-2006. There he studied the biochemical effects of red wine polyphenols on the production of nitric oxide in blood vessels and the subsequent control of blood pressure. Following this he continued for another year in the same lab using chromatography to study the uptake of these same compounds into the blood, by extracting and measuring them. Mark joined Malvern in 2008 as a product technical specialist for the Zetasizer Nano and Viscotek products concentrating on bioscience SEC applications. In 2010, he took the role of Product Manager for Zetasizer and Viscotek products where he acts as the 'Voice of the Customer' for new products and on quality issues and recently moved to our Houston office to engage more closely with product developments there. Mark joined Malvern in 2008 as a product technical specialist for the Zetasizer Nano and Viscotek products concentrating on bioscience SEC applications. In 2010, he took the role of Product Manager for Zetasizer and Viscotek products where he acts as the 'Voice of the Customer' for new products and on quality issues and recently moved to our Houston office to engage more closely with product developments there.

Gel permeation chromatography, Molecular structure, Molecular weight, OMNISEC, Size Exclusion Chromatography »

[12 Sep 2018 | ]

When thinking about a reason to purchase a particular piece of scientific equipment, you want to know not only that you are getting the best piece of kit, but also that you’ll be maximizing the return on your investment.  Manufacturers like Malvern Panalytical can add value to their products in a variety of ways, and one is the support and materials you’ll get to help you make the most of your purchase.  In this blog, I want to tell you about the additional benefits and added value that you’ll receive …

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[21 Jun 2018 | ]

Almost always, my favorite thing about working for a scientific technology company is getting to work on the latest technologies and learn about the applications available to them.  We’re fortunate enough to see the newest technology and play with the newest toys, pushing their limits and finding out what can be achieved.
In the GPC/SEC team, our latest development is the ability to connect our OMNISEC REVEAL multi-detector module to an ultra-performance liquid chromatography (UPLC) system like the Waters ACQUITY APCTM.  Connecting our multi-detectors to UPLC systems is something we have struggled with …

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Corporate, Gel permeation chromatography, Malvern Panalytical Events, OMNISEC »

[1 May 2018 | ]

Malvern Panalytical recently announced a co-marketing agreement with Waters Corporation for the use of our advanced GPC/SEC (Gel Permeation Chromatography / Size Exclusion Chromatography) detectors with their UPLC system, the APC.  Our advanced detector module OMNISEC REVEAL includes a refractive index (RI), a UV/Vis photodiode array, light scattering for measuring molecular weight, and a viscometer for measuring molecular structure.  The Waters ACQUITY APC uses columns with advanced, small particles to generate high-resolution separations in short run times.
In the past these systems haven’t been able to work together because the resolution is lost as …

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Gel permeation chromatography, Molecular weight, OMNISEC, Size Exclusion Chromatography, Tech Talk »

[23 Feb 2017 | ]

Recently, I’ve presented a new webinar focusing on the protein characterization using the OMNISEC, the highest quality Gel Permeation Chromatography (GPC) / Size Exclusion Chromatography (SEC) system for the measurement of absolute molecular weight, molecular size, intrinsic viscosity, branching and other parameters. Thank you to all participants for your interest and attention during the webinar.
In this webinar, I highlighted the key features and benefits of the OMNISEC system. How to run samples and analyze data and how to access repeatability of multiple sample measurements.

As usual, after the live section of …

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Customer experience, OMNISEC »

[3 Jan 2017 | ]

One of the best parts of a job as a Product Manager or Technical Specialist is the continual learning that comes from customer interactions, relationships and collaborations. Visiting a new lab, learning about new areas of research and helping to guide measurements with real meaning and consequences is both enjoyable and rewarding.
This is particularly true when starting a new academic collaboration.  At Malvern, we’re pleased to announce that we are starting a new collaborative partnership with Professor Rigoberto Advincula at Case Western Reserve University (CWRU) to use advanced multi-detector gel-permeation …

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[12 Jul 2016 | ]

Note: only valid for US
One of the best things about working in the technical sales support team is learning about the vast array of applications that customers are using our instruments for. Whether it’s protein oligomerization and aggregation for biopharmaceuticals; polymers for research, fabrics or coatings; or polysaccharides in foods and pharmaceuticals, it’s always fascinating to hear how polymers are being made, characterized, and used.
We always enjoy hearing about the latest polymer research and we want you to challenge us to make GPC/SEC measurements of your most interesting, and possibly challenging …

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Gel permeation chromatography, Molecular size, Molecular structure, Molecular weight, OMNISEC, Size Exclusion Chromatography, Tech Talk »

[14 Jul 2015 | ]

Multi-detector SEC – 10 reasons why protein scientists need one
In a previous post I listed the top ten reasons why a polymer characterization scientist might want to upgrade to multi-detector Gel Permeation Chromatography/Size Exclusion Chromatography, but there are similar points to be made as to why a protein characterization scientist might do the same.  We often focus on the benefits of our own systems but sometimes we may miss the benefits of the basic technique.
If you are a protein characterization scientist and you find yourself thinking, “My UV detector works …

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Gel permeation chromatography, Molecular size, Molecular structure, Molecular weight, OMNISEC, Tech Talk »

[19 Jun 2015 | ]

When we are talking to customers about advanced Gel Permeation Chromatography (GPC) systems, we can explain why ours are the best on the market or how their excellent sensitivities means you can measure polymers with lower molecular weight than ever before.  We could tell you how the latest system, OMNISEC, reduces servicing time and costs with its new design of viscometer. Sometimes though we come across the question of why someone would want to invest in a multi-detector advanced GPC system.
Maybe you are thinking, “I’ve got a conventional system with …

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Molecular structure, Molecular weight, Protein Aggregation »

[21 May 2015 | ]

We recently published a new application note on protein characterization using our latest SEC system, OMNISEC, and I wanted to bring your attention to this elegant piece of work that beautifully shows the kind of information you can get from a multi-detector system and, perhaps more importantly, the kind of information you might be missing from a single-detector, UV-based system.The chromatogram below shows a typical chromatogram of a standard protein,    β-amylase:

It looks pretty typical with a monomer and a small amount of aggregates, right? Wrong!
Let’s looks again with a multi-detector …

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Gel permeation chromatography, Molecular weight, OMNISEC, Size Exclusion Chromatography, Tech Talk »

[25 Mar 2015 | ]

A couple of weeks ago I had the opportunity to present a live webinar through Chemical & Engineering News about how our latest solution for Gel Permeation Chromatography/Size Exclusion Chromatography (GPC/SEC), OMNISEC, can help our customers with their synthetic polymer applications.
OMNISEC is a complete system for GPC/SEC measurements including a pump/degasser/autosampler module in OMNISEC RESOLVE and an advanced multi-detector module including RI, UV/Vis, Light scattering and IV detectors in OMNISEC REVEAL.
During the webinar we covered measurements from simple polymers like polystyrene to fascinating drug delivery polymers such as PLGA. At …

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Gel permeation chromatography, Malvern Panalytical Events, Molecular structure, Molecular weight, OMNISEC, Size Exclusion Chromatography, Tech Talk »

[10 Mar 2015 | ]

I’m currently at Pittcon, the annual laboratory science conference and expo.  This year it’s in New Orleans, not too far from our factory in Houston.  Since New Orleans is known for its Cajun food and the Food Labs conference is going on at the same time, it made me think of the ways OMNISEC, our latest Gel Permeation Chromatography/Size Exclusion Chromatography (GPC/SEC) system can be used to support work in the food industry.
I’m sure you know that there are plenty of polysaccharides in processed foods but did you know how …

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Gel permeation chromatography, Molecular structure, Molecular weight, OMNISEC, Size Exclusion Chromatography, Tech Talk »

[5 Feb 2015 | ]

GPC detector – OMNISEC – Your Questions Answered

Thanks so much to those of you who joined us for the launch of  OMNISEC, our new GPC/SEC system.  If you missed the event you can play it back by clicking here, to see how the new instrument can really enhance the characterization of polymers and proteins.  
Amy and I really enjoyed the launch and were thrilled by the interest it generated.  Many of you sent through questions during the event, and though I answered as many as possible inevitably there were too many to cover live.  As …

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Gel permeation chromatography, Molecular weight, Size Exclusion Chromatography, Tech Talk, Viscotek »

[23 Dec 2014 | ]

As Christmas is getting ever closer, thoughts turn to gift giving and receiving. As the product manager for our Viscotek range, I can’t help but think in scientific terms when assessing what kind of present I would like to receive. So the question is this – which makes the best gift, one with a high molecular weight (MW), high intrinsic viscosity (IV) or both?
At the bottom end of the Christmas present scale is surely the ubiquitous gift of socks.  Socks make a small, lightweight present and can therefore represent low molecular weight.  They are easily foldable into a …

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Molecular weight, Tech Talk »

[19 Jun 2014 | ]

I recently came back from a sailing holiday in the Caribbean.  I hadn’t been sailing before but I couldn’t help but think that the ropes we used make the perfect analogy for polymers.
In simplest terms, the longer the rope, the higher the molecular weight.  Although we had many shorter ropes on the boat (contributing to the number average, Mn), the total mass of rope was probably mostly contained in the longest ropes used to hoist the sails (contributing to a higher weight average, Mw).  A bit more information and we’d …

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Archimedes, Corporate, Dynamic Light Scattering, Malvern Panalytical Events, Meet the Experts, Molecular weight, Resonant mass measurement, Size Exclusion Chromatography, Tech Talk, Viscotek, Zetasizer »

[29 Nov 2012 | ]
Join us for the launch of Archimedes!

At Malvern, the launch of a new product is always an exciting time.  With our stated goals of growing into the biopharmaceutical market to satisfy their development needs, the launch of a product to help us achieve this goal is particularly so.
That’s why we’re so excited about the upcoming launch of Archimedes.  Archimedes is a novel system that can count particles in the size range of 50 nm to 5 µm using the technology of Resonant Mass Measurement (RMM).  RMM delivers true size distributions based on the buoyant mass of …

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Corporate, Gel permeation chromatography, Size Exclusion Chromatography, Viscotek »

[22 May 2012 | ]
New GPC/SEC challenges after moving to Houston

With the recent opening of our new facility in Houston, the total effort going into our separations products is continuing to grow.  The large applications laboratory and training facilities are great for new and existing customers to see and the first customer training course that took place a couple of weeks ago was very well received.  At the same time, the manufacturing and development facilities have been greatly increased to support the growing demand for the Viscotek GPC/SEC products now and in the years to come.
As part of the growth …

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Tech Talk, Zeta potential, Zetasizer »

[26 Apr 2012 | ]
What would the polymer chemist do?

To someone who works on measurements of both polymers and proteins with the Viscotek and Zetasizer instruments, the similarities between the two samples are very clear. Both are made from repeating monomeric units and the function of both is highly dependent on their molecular weight, size and structure. In polymers, the repeating unit is typically a single monomer or co-monomer whereas in proteins the repeating units are amino acids, of which there are about 20 that can be joined in any sequence and this, of course, is one of the …

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Molecular weight, Size Exclusion Chromatography »

[7 Feb 2012 | ]
Applying Leonardo’s legacy for better Size Exclusion Chromatography

In his blogs; ‘Why has laser diffraction endured?’ and ‘Evolution of particle sizing techniques’, my colleague Paul Kippax found himself wondering what Leonardo da Vinci would have thought of laser diffraction. Well, as he was someone who firmly believed that to truly understand something under observation it is important to investigate it from multiple perspectives, I feel da Vinci would have also approved of the idea of multi-detection Size Exclusion Chromatography (SEC).
Our work here at Malvern really does rely heavily and reflect and build upon, many of the great man’s …

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Corporate, Molecular weight, Size Exclusion Chromatography »

[16 Nov 2011 | ]
You are invited to an LC-GC webcast

A new LC-GC webcast sponsored by Malvern Instruments highlights the advantages of using multiple detection in size-exclusion chromatography.
Thursday, December 1, 2011
11:00 AM (EDT) 16:00 PM (GMT) 17:00 PM (CET)
The Benefits of Moving from Single to Multi-detector Size-exclusion Chromatography
Register Free
Multi-detector Size-exclusion Chromatography
Size-exclusion chromatography (SEC) is a useful and uncomplicated technique for analyzing complex macromolecules such as synthetic polymers, polysaccharides and proteins that it hardly needs much introduction. However, its utility can be markedly improved by the use of multiple detectors.
Molecular weight is calculated in different ways by light scattering, refractive index …

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Corporate, Dynamic Light Scattering, Size Exclusion Chromatography, Viscotek »

[7 Mar 2011 | ]
Sizing up the situation

As someone who is new to the blog, I would like to introduce myself. My name is Mark Pothecary and I am product technical specialist for the separation sciences product line at Malvern Instruments. My background is biochemistry and here at Malvern I develop nanoparticle characterization and size-exclusion chromatography (SEC) applications – also referred to as Gel Permeation Chromatography (GPC). You may already be familiar with my webinars about advanced multi-detector SEC and technical applications.
Updating busy scientists
In February I had the opportunity to speak at a series of seminars in …

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