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Particle shape

Particle shape can have a significant impact upon the performance and process handling of many particulate materials.

Chemical identification, Image Analysis, Meet the Experts, Morphologi G3-ID, Particle shape, Raman spectroscopy »

[29 Sep 2017 | ]

I have just come back from presenting my talk ‘Application of Morphologically-Directed Raman Spectroscopy in deformulation and in vitro bioequivalence studies’ at the pharma focus session of Powtech 2017.
The talk indicated how there are still many drug products that have come of patent but do not yet have generic equivalents available and how there is a drive from the regulatory bodies to make health care more accessible and so they are producing many guidance documents to help address this.
I gave an overview of a proposed workflow for developing generic drug …

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Archimedes, Binding affinity and Kd, Chemical identification, Differential Scanning Calorimetry, Dynamic Light Scattering, Gel permeation chromatography, Image Analysis, Label-free analysis, MicroCal, Microcalorimetry, Morphologi G3-ID, Nanoparticle Tracking Analysis, Nanosight, Particle concentration, Particle shape, Particle size, Protein Aggregation, Raman spectroscopy, Resonant mass measurement, Rheology, Size Exclusion Chromatography, Taylor Dispersion Analysis, Tech Talk, Viscosizer TD, Viscotek, Zetasizer »

[21 Sep 2017 | ]

I know this sounds like the beginning of a bad joke, but in this case, it was actually the beginning of the 2017 Colorado Protein Stability Conference, held in July at Beaver Run Resort in Breckenridge, Colorado. In attendance was a range of scientists and researchers from all over the world, with one common subject in mind: Protein Stability.

One of the highlights of this conference was the pre-conference workshop. This was a free workshop for all attendees of the conference, which was sponsored by Malvern Panalytical. The workshop included a range …

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Chemical identification, Image Analysis, Meet the Experts, Morphologi G3, Morphologi G3-ID, Particle shape »

[7 Sep 2017 | ]

Standing at just under 3800 m tall with its distinctive symmetrical cone-shaped peak, the majestic Mount Fuji, or Fujisan (富士山) as it is known locally, is one of the most iconic symbols of Japan.
Therefore, it seemed only appropriate that whilst on secondment in Malvern’s Tokyo application lab, I should attempt to reach the summit of this famous volcano and, in something of a cliché, watch the sunrise from the highest peak in the Land of the Rising Sun.
There is only a short window each year in which one is permitted …

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Morphologi G3-ID, Particle shape, Raman spectroscopy, Tech Talk »

[31 Aug 2017 | ]

GEN covers the role of MDRS in reducing the need for clinical bioequivalence endpoint studies
 
Morphologically-Directed Raman Spectroscopy (MDRS) combines the capabilities of automated imaging with Raman spectroscopy in a single platform, creating a powerful analytical tool that spans multiple industries. It exhibits particular value in both innovator and generic pharmaceutical development, as detailed particle characterization enables a thorough understanding of individual materials and how they impact the final product – as demonstrated by a recent Malvern Panalytical article, featured on the GEN website.
 
Raman spectroscopy and MDRS enable determination of the …

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Archimedes, Chemical identification, Label-free analysis, Malvern Panalytical Events, MicroCal, Microcalorimetry, Molecular size, Molecular structure, Molecular weight, Morphologi G3-ID, Nanosight, Particle concentration, Particle shape, Particle size, Protein Aggregation, Protein Mobility, Viscosizer TD, Zeta potential, Zetasizer »

[16 May 2017 | ]

With Pre-Conference Workshop on Biophysical Characterization and Particle Analysis
 

Date: July 17th – 20th.
We at Malvern know that protein stability is important in numerous disciplines, ranging from basic and medical biochemistry to pharmaceutical sciences. However, it is rare that researchers from all the relevant areas can join to discuss the critical issues in the field. The 2017 Colorado Protein Stability Conference provides a unique forum for this exchange of information. The topics to be covered include protein folding, dynamics and thermodynamic stability; amyloidosis and protein aggregation; and stability, formulation, analysis and processing …

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Français, Insitec, Laser Diffraction, Malvern Panalytical Events, Meet the Experts, Particle shape, Particle size »

[2 May 2017 | ]

Malvern organise des formations en collaboration avec la société SDTech Micro et SDTech Nano, son partenaire technique depuis 7 ans.

SDTech Micro, situé à Alès, est spécialisé dans l’analyse et le traitement à façon des poudres fines et ultrafines.
La semaine derniere, SDtech organisait les journees techniques avec Glatt et Malvern. Des présentations théoriques s’enchainerent avec des ateliers sur un granulateur Glatt en mode “granulation” le premier jour puis en mode “enrobage” le deuxième jour.

 

En parallèle une démonstration de broyage sur un microniseur à jet d’air contrôlé entièrement par un granulomètre laser …

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Malvern Panalytical Events, Particle shape, Particle size, Rheology »

[6 Oct 2016 | ]

Best practices for characterizing and manufacturing battery slurries and electrodes
The market for batteries is rapidly growing, and the increased demand for portable electronic devices, including mobile phones and laptops requires greater advances in battery technology in order to provide a light weight, long lasting and stable power source. Battery technology is also being pushed further in electric vehicle applications, which require even more lightweight, higher power and faster charging batteries.

Critical for the development and production of a battery is getting the right material composition and putting it together in such …

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Chemical identification, Image Analysis, Laser Diffraction, Malvern Panalytical Events, Mastersizer, Morphologi G3-ID, Particle shape, Particle size, Raman spectroscopy »

[29 Jun 2016 | ]

Over the past week I’ve had a lot of fun working with Malvern’s team in China to deliver a series of seminars designed to help researchers engaged in pharmaceutical product development. These meetings focused on how Malvern’s material characterization systems can help those developing and manufacturing oral solid dose formulations. During the seminar series, we had the privilege of meeting with well over 200 customers, providing us with the chance to learn about the challenges they are facing in product development, as they seek to select APIs and excipients which …

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Chemical identification, Image Analysis, Laser Diffraction, Mastersizer, Meet the Experts, Morphologi G3-ID, Particle shape, Particle size, Raman spectroscopy, Tech Talk »

[20 Jun 2016 | ]

Component-specific Particle Size
Follow that particle!

I’ve always thought it would be great to be the innocent driver in a movie chase scene who has to respond to the hero’s demand to ‘Follow that car’ as they try to keep tabs on the villain. I always imaged that this would unlock the silent racing driver within me, giving me the excuse to forget about speed limits and drive at the limits of my car’s performance. I’d also get the chance to practice my handbrake turns!
Although I have never been engaged in a …

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Chemical identification, Kinexus, Morphologi G3-ID, Particle shape, Spraytec, Tech Talk »

[14 Jun 2016 | ]

MDRS Technology
Finally!  After what has felt like one of the wettest and longest winters in memory here in the UK, we’re now heading into the long, mellow days of midsummer.
But casting its miserable shadow over the barbecues, school holidays and paddling pools is the dreaded allergy season.  As one of the downsides of life in our “green and pleasant land”, during June we are hit hard by the combined impact of pollen from trees, grasses and weeds.
Many of us are now taking a daily antihistamine of some sort, and others …

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Particle shape, Particle size »

[25 Mar 2016 | ]

In the UK we are about to celebrate Easter, where we get the chance to spend a few days relaxing with family and friends and enjoying the start of spring. It is traditional at this time of year to give away chocolate Easter eggs, as a symbol of new life.
So, for me, the hunt is on for the perfect Easter egg for my family. As I do this, the questions I find myself asking are:

What size is it?
What shape is it?
What does it contain?

Interestingly these are precisely the same questions …

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Particle shape, Particle size »

[25 Nov 2015 | ]

Ever thought about measuring the size of a potato?  We’ll probably be consuming vast quantities of these in various forms (fries, roasted, mashed, even potato salad which signals summer in the US). Well, the humble potato is a good example of the philosophy of the most basic particle size question “What size is my particle?”. Do we buy our potatoes on the basis of number (I can understand this for large baking potatoes or the tiny new potatoes we used to see every year in my youth in England – now of …

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Mastersizer, Meet the Experts, Particle shape »

[8 Oct 2015 | ]

Hello once again from the Malvern development labs!
You may remember I wrote a blog last year about the Dispersion Index parameter on the Hydro Sight and how it can be used to supplement Mastersizer information on the dispersion state of your sample.  Well, in this blog I’m going to introduce you to another novel feature of the Hydro Sight:  automatic anomaly detection.  (There’s also a little game at the end that you can all play at home – and prizes are at stake….)
 
 
 
This feature is very useful for troubleshooting problems …

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Image Analysis, Morphologi G3-ID, Particle shape, Particle size, Raman spectroscopy, Tech Talk »

[11 Aug 2015 | ]

When working with a couple of our Morphologi G3-ID cement customers I have come to realize that cement is an incredibly complex product. Working with one of our customers in the cement industry we wrote an article, published last year in International Cement Review, discussing some of the challenges facing the cement industry and how the Morphologi G3-ID can help face these challenges.
Cements can contain a large number of components including any number of additives to adapt the cement behavior, the size and shape of any of these components can …

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Particle shape, Particle size, Tech Talk »

[10 Jul 2015 | ]

The longer you work at Malvern Instruments, the more likely you are to see anything and everything as something which has been optimized by material characterization in some form. As it’s the week of The Open at St Andrews, let’s take the golf course as an example. Surely particle science has no place here does it? Well it does, in fact, it has been deliberately designed to have a particularly perfect particle size.
The most obvious place to start, but the hardest to escape from, is the bunker. The particle size …

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Molecular size, Molecular structure, Molecular weight, Particle shape, Protein Mobility, Zetasizer »

[30 Jun 2015 | ]

The Zetasizer has some optional advanced protein features that you may not be aware of:
DLS Debye Plot: a dynamic Debye plot of the measured hydrodynamic size as a function of sample concentration to obtain the dynamic Virial coefficient (also known as kd, or interparticle interaction parameter)
Mixture Viscosity: estimates the viscosity of a mixture of dispersants of known viscosity, using the assumption that the total viscosity is a volume fraction weighted sum of the component viscosities. The mean viscosity is based on the volume fraction and the individual viscosities of the component …

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Laser Diffraction, Mastersizer, Particle shape, Particle size, Sysmex FPIA-3000, Tech Talk »

[14 May 2015 | ]

In this series of blogs I, and some of my colleagues, would like to share some of our experience in particle sizing for industrial applications. I thought we’d do this by going through an A to Z of industrial applications and as Aardvarks are too big for our instruments, we’ll start with A for abrasives.
To be an abrasive, a material needs to be harder than the material that you want remove or polish (unless you have got a very, very long time to wait – think glacial!). The original scale …

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Particle shape, Tech Talk, Zetasizer »

[21 Apr 2015 | ]

What laser is used in the Zetasizer Nano series? This question came to me via one of our Malvern account managers, so I thought a brief explanation could help clarify which laser and which detector is used in the systems.
Helium Neon HeNe lasers (λ=632.8nm) were the first commercial lasers, and they have superior beam qualities (for example in stability, mode, and coherence length).  Since they have been around for decades, they are also reliably durable. Traditionally the first light scattering experiments were conducted using various gas lasers and photo multiplier tubes PMTs …

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Customer experience, Mastersizer, Morphologi G3, Parsum, Particle shape, Particle size, Spatial Filter Velocimetry, Tech Talk »

[8 Apr 2015 | ]

Fluidized Bed Coating
Improving the fluidized bed coating process with PAT & AI
Leia este blog no Português
On the morning of February 25, 2015, a doctoral defense was performed by Carlos Alexandre Moreira da Silva, Master in Chemical Engineering from University State of Campinas (Unicamp), under Prof. Dr. Osvaldir Taranto Pereira’s supervision.
The thesis titled “Application of Process Analytical Technology and Artificial Intelligence to monitor and control a fluidized bed coating process” developed in Chemical Engineering Faculty at the State University of Campinas, set an innovation in the study of the key parameters involved …

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Customer experience, Parsum, Particle shape, Particle size, Português, Spatial Filter Velocimetry, Tech Talk »

[8 Apr 2015 | ]

Read this blog post in English
Na manhã do dia 25 de fevereiro de 2015, foi realizada a defesa de doutorado de Carlos Alexandre Moreira da Silva, Mestre em Engenharia Química pela Unicamp, sob a orientação do Prof. Dr. Osvaldir Pereira Taranto, Chefe de Gabinete Adjunto da Reitoria da Unicamp.
A tese “Aplicação de Tecnologias Analíticas de Processo e Inteligência Artificial para Monitoramento e Controle de Processo de Recobrimento de Partículas em Leito Fluidizado”, desenvolvida na Universidade Estadual de Campinas (Faculdade de Engenharia Química), configurou uma inovação no estudo dos parâmetros essenciais …

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