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Particle size

Particle size distributions from sub-nanometer to millimeters.

By far the most important physical property of particulate samples is particle size. Measurement of particle size distributions is routinely carried out across a wide range of industries and is often a critical parameter in the manufacture of many products.

Corporate, Dynamic Light Scattering, Electrophoretic light scattering, Molecular size, Molecular weight, Particle concentration, Particle size, Zeta potential, Zetasizer »

[23 May 2018 | ]

Where is the Zetasizer used?
 
For around two decades, the Zetasizer range has been the de facto standard for performing dynamic light scattering (DLS) measurements on a wide range of particles and materials.
Our launch of the Zetasizer Pro and Zetasizer Ultra – taking place on May 23rd, 2018 – provides a good reason to summarize the key application areas for light scattering technology: both dynamic and electrophoretic! Where are these Zetasizers used? Where can we find them, in the real world?
Below is a list of key application focus areas:

Bioscience and biopharmaceuticals: simple purity and stability …

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Customer experience, Dynamic Light Scattering, Molecular size, Particle size, Tech Talk, Zetasizer »

[15 May 2018 | ]

The peaks in your distribution are out of order?
We recently received an email about the order of peaks in the Zetasizer software:
For data evaluation, is it possible to rearrange the NNLS results by order of particle size populations?”
How the peaks are shown (by area)

Size measurement results are typically viewed in the Intensity PSD (M) tab. This is part of the standard Size and Summary workspaces.  When a record contains more than one peak, these results will be tabulated in the table above the intensity size distribution. The default ordering in …

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Chemical identification, Image Analysis, Malvern Panalytical Events, Morphologi, Particle shape, Particle size »

[8 May 2018 | ]

Interested in the size, shape and chemical identity of your particles?
 
Have an application where particle shape plays a critical role, such as particle packing or adhesion to surfaces?
 
Need forensic evaluation of a failed batch, or identification of a contaminant in the process line?
 
A recent value analysis shows that a customer’s use of MDRS for component-specific particle characterization helped them save up to $500,000 when compared to conventional analysis.
Malvern Panalytical
117 Flanders Road, Westborough, MA
Thursday, May 10 2018, 8:30 – 1:30
This seminar is your chance to learn more about Morphological Imaging for the …

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Insitec, Laser Diffraction, Mastersizer, Particle size, Tech Talk »

[17 Apr 2018 | ]

What is IIoT?
We now live in a world where there is an increasing reliance on the internet, not only for streaming movies or sending e-mails but for controlling a multitude of devices from domestic appliances to smart cars. The internet of things has also been embraced by the manufacturing industry, a paradigm known as the IIoT (Industrial Internet of Things) – when separate manufacturing units begin to function as one – and where the cloud is becoming the preferred way to store and share data.
Data has now become the lifeblood …

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Elemental analysis, Empyrean, Epsilon, Français, Image Analysis, Malvern Panalytical Events, Mastersizer, Meet the Experts, Particle shape, Particle size, X'Pert3, X-Ray Diffraction (XRD), X-Ray Fluorescence (XRF), Zeta potential »

[22 Mar 2018 | ]

Malvern Panalytical sera à Forum Labo Biotech Lyon, Stand A12, (en bas des escalators) les 28 et 29 mars 2018. Forum Labo est le salon des fournisseurs de matériels et services pour le laboratoire.
Venez voir en exclusivité le nouveau granulomètre et analyseur de forme Morphologi 4 ainsi que 3 autres nouveaux instruments inédits !
Vous pourrez découvrir :

Un nouveau rhéomètre avec de nouvelles fonctionnalités,
Des passeurs d’échantillons pour Zetasizer, Nanosight NS300,

Un nouveau spectromètre de fluorescence X Epsilon 4 de la gamme Panalytical.

Toute notre équipe de spécialistes d’application sera présente, prête à répondre à toutes vos questions …

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Aeris, ASD, Epsilon, Laser Diffraction, Malvern Panalytical Events, Mastersizer, Near-InfraRed spectroscopy (NIR), Particle size, TerraSpec, X-Ray Diffraction (XRD), X-Ray Fluorescence (XRF) »

[22 Feb 2018 | ]

Malvern Panalytical will be in Minnesota, United States at the SME Annual Conference & Expo from February 25-28th!
SME is the Society for Mining, Metallurgy & Exploration Inc. This event gathers together the mining and mineral community, comprised of engineers, geologists, metallurgists, educators, students and researchers. The society advances the worldwide mining and underground construction community through information exchange and professional development.

ASD TerraSpec® Halo
We invite you to come discover the product lines of Malvern Panalytical and what we can do for your mining and mineral needs. Find the following instruments in our …

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Dynamic Light Scattering, Gel permeation chromatography, Kinexus, Laser Diffraction, Malvern Panalytical Events, Meet the Experts, Molecular weight, Nanoparticle Tracking Analysis, Nanosight, OMNISEC, Particle concentration, Particle size, Rheology, Rheometry, Tech Talk, Viscotek, Zeta potential, Zetasizer »

[30 Jan 2018 | ]

We will be attending Pittcon 2018 in Orlando, Florida Feb 26th – Mar 1st and once again we are pleased to feature a number of our recognized characterization experts who will be presenting a variety of short courses throughout the week.
Time is running out, so don’t miss out on the early bird deadline for discounted admission which ends on February 5th.
Below is a listing of our available short course offerings.
We look forward to seeing you in Orlando at one of our short courses and our Booths #2118 & #2119.
Monday, February 26th
Fundamentals of Particle …

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Image Analysis, Meet the Experts, Morphologi, Particle shape, Particle size »

[28 Dec 2017 | ]

After a break of 4 years, it was great to get back to the Drug Delivery to the Lungs conference (DDL2017) in Edinburgh this year. After the snow and gales of previous years when I have visited it was rather quiet in terms of weather this year, but not in terms of content as this was varied and interesting. I caught up on some of the latest advances in inhaled device development targeting special populations, such as small children or critically ill patients. It was really exciting to see the …

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Differential Scanning Calorimetry, Dynamic Light Scattering, MicroCal, Molecular size, Molecular structure, Particle size, Protein Aggregation, Tech Talk, Zetasizer »

[16 Nov 2017 | ]

Measuring aggregation temperature using the Zetasizer

In dynamic light scattering (DLS), the hydrodynamic size and size distribution of particles in solution can be obtained.  It may be of interest to examine this measurement as a function of time and temperature, or as a ‘trend’, as it is called in the Malvern Zetasizer software.  For biological protein samples, this temperature trend is particularly interesting: although at low temperatures a protein may be stable and show repeatable size (and scattering intensity) measurements, typically at some elevated temperature (Tagg), protein molecules will show a tendency …

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Français, Insitec, Laser Diffraction, Malvern Panalytical Events, Meet the Experts, Particle size »

[15 Nov 2017 | ]

Le Salon des technologies des solides et liquides en vrac

Nous serons présents sur le Salon Vrac Tech du 28 au 30 novembre 2017 – Hall C – Stand A19.
Vous pourrez découvrir nos granulomètres laser pour contrôler vos procédés de fabrication de poudres jusqu’à 1 mm et des sondes pour mesurer des granulés en ligne jusqu’à 6 mm. En effet, le contrôle des procédés de broyage intéresse et concerne de plus en plus d’usines de l’industrie alimentaire.
Rejoignez nous et demandez votre badge!
Informations pratiques :
Parc des Expositions du Mans
1, Avenue du Parc des Expositions
72100 Le Mans
Coordonnées …

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Insitec, Laser Diffraction, Malvern Panalytical Events, Particle size »

[19 Oct 2017 | ]

Downstream in-line monitoring for better processes and products
Every second is critical towards rectifying a plant upset or ensuring efficient plant management. What if you could incorporate in-line analysis for your dry and liquid products?
Companies that introduced in-line particle size analysis at the milling stage noticed significantly less over-milling. Hence seeing as much as a 2% increase in plant throughput. In-line elemental analysis allows petrochemical companies to closely monitor Fe, Ni, V which destroy expensive catalysts.
Why incorporate in-line analysis?

Real-time monitoring of your batches
Make immediate corrections to poor batches
Prevent wastage
Improve your manufacturing …

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Insitec, Laser Diffraction, Mastersizer, Meet the Experts, Particle size »

[5 Oct 2017 | ]

The heavy cost of mining and minerals manufacturing
The importance of minerals as a production resource applies to many facets of our daily lives. For instance, the quality of concrete determines the smoothness of a road surface and the sturdiness of a building. However, with the ever-growing demands for quality cement, many have spurred manufacturing processes leading to hefty costs. Such costs incurred comes from wastage when having to reproduce cement because it does not meet the quality standard.
Based on a mechanical and civil engineering study, 6-15% of construction costs …

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Dynamic Light Scattering, Particle size, Tech Talk, Zetasizer »

[26 Sep 2017 | ]

Is there a maximum viscosity for DLS measurements?
 
The Malvern Zetasizer can determine particle size by dynamic light scattering (DLS). In this technique, the intensity fluctuations are analyzed to find the corresponding diffusion coefficient that led to the fluctuations. The translational diffusion coefficient Dt of a particle is inversely related to its size and the viscosity of the dispersant (or more accurately the hydrodynamic radius rH and viscosity η).

This relationship can be used to predict detectability limits of the technique in general, and this is how we explore the idea of …

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Archimedes, Binding affinity and Kd, Chemical identification, Differential Scanning Calorimetry, Dynamic Light Scattering, Gel permeation chromatography, Image Analysis, Label-free analysis, MicroCal, Microcalorimetry, Morphologi, Nanoparticle Tracking Analysis, Nanosight, Particle concentration, Particle shape, Particle size, Protein Aggregation, Raman spectroscopy, Resonant mass measurement, Rheology, Size Exclusion Chromatography, Taylor Dispersion Analysis, Tech Talk, Viscosizer TD, Viscotek, Zetasizer »

[21 Sep 2017 | ]

I know this sounds like the beginning of a bad joke, but in this case, it was actually the beginning of the 2017 Colorado Protein Stability Conference, held in July at Beaver Run Resort in Breckenridge, Colorado. In attendance was a range of scientists and researchers from all over the world, with one common subject in mind: Protein Stability.

One of the highlights of this conference was the pre-conference workshop. This was a free workshop for all attendees of the conference, which was sponsored by Malvern Panalytical. The workshop included a range …

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Customer experience, Dynamic Light Scattering, Particle size, Zeta potential, Zetasizer »

[22 Aug 2017 | ]

Zetasizer: 21CFR? Electronic Record/Electronic Signature? Test Schedule?
 

The Malvern Zetasizer is an extremely versatile measurement system. By far the most systems are used in academic and industry research laboratories, for example in fundamental research, drug discovery, or formulation optimization. However, a significant number of installations are in operation in “controlled” environments, such as for quality control in pharmaceutical companies. Here documentation and compliance with good manufacturing standards GMP is critically important, and a specific version of the operating software exist that locks down standard operating procedures (SOP) with limited ability (based …

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Dynamic Light Scattering, Electrophoretic light scattering, Laser Diffraction, Particle size, Zeta potential, Zetasizer »

[3 Aug 2017 | ]

Intralipid-Lipid emulsions

Lipid emulsions are administered intravenously for a variety of purposes:

To help feed patients with temporary difficulty in ingesting food orally
For better transport of lipophilic drugs (fat-friendly active ingredient (API) which is not soluble in water)
For controlled release of drugs (size related to uptake and retention)
To decreasing adverse reactions to drugs
To improve targeting of drugs
In emerging gene therapies for cellular and gene delivery, and personalized medicine

Control and understanding of colloidal properties – such as droplet size and zeta potential – enable the design and optimization of appropriately stable emulsions. The …

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Laser Diffraction, Mastersizer, Particle size, Tech Talk »

[1 Aug 2017 | ]

Just when I thought I’d seen everything that could contaminate the background, a user sent me this picture! The Musca Domestica (common housefly) was attracted by certain aromatics used in testing and seems to have entered the measurement cell through an empty Hydro EV over a weekend. Unfortunately, it became wedged within the measurement cell and did not survive the experience.

The most important message from the Mastersizer training courses I give is to make sure you have a good background before you start. Laser diffraction is a background subtracted technique: …

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Customer experience, Dynamic Light Scattering, Meet the Experts, Particle size, Zetasizer »

[20 Jun 2017 | ]

Three methods to verify dynamic light scattering systems
If you are a meticulous researcher you may want to test your new Zetasizer. Is it really providing the correct size? One of the advantages of dynamic light scattering is that there are no tweakable adjustments, it is all physics: laser wave length, scattering angle, refractive index of the dispersant are all known in advance and are given parameters for the optical setup and sample. Nevertheless, it is a good idea to check and verify the performance of the system. One of the …

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Laser Diffraction, Mastersizer, Meet the Experts, Particle size, Tech Talk »

[13 Jun 2017 | ]

I recently presented a webinar exploring the practical aspects of sieving method – the advantages and disadvantages.  I compared the method to other techniques such as laser diffraction indicating the increased wealth of information that can be obtained with these more modern instrumental techniques and the common pitfalls and assumptions of the screening technique.
More than 800 of you registered for the webinar and I received a large numbers of interesting questions which I have been working steadily through. I thought it would be a good idea to share the questions and answers via the blog, so here they …

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Archimedes, Customer experience, Differential Scanning Calorimetry, Gel permeation chromatography, Image Analysis, MicroCal, Morphologi, Nanoparticle Tracking Analysis, Nanosight, Particle size, Protein Aggregation, Raman spectroscopy, Resonant mass measurement, Viscotek »

[1 Jun 2017 | ]

Our key driver at Malvern Instruments is to create technologies that make a difference or solve a problem, and working hand-in-hand with our customers enables us to make sure that’s exactly what’s happening, out in the field.  We place a high value on our collaborations and partnerships with customers from a wide range of industries and organizations across the globe and love to see how our systems are being used in real-world scenarios.  This gives us vital feedback on what we’re doing well, and also any tweaks we need to make in order to optimize …

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