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Particle size

Particle size distributions from sub-nanometer to millimeters.

By far the most important physical property of particulate samples is particle size. Measurement of particle size distributions is routinely carried out across a wide range of industries and is often a critical parameter in the manufacture of many products.

Insitec, Laser Diffraction, Malvern Panalytical Events, Particle size »

[19 Oct 2017 | ]

Downstream in-line monitoring for better processes and products
Every second is critical towards rectifying a plant upset or ensuring efficient plant management. What if you could incorporate in-line analysis for your dry and liquid products?
Companies that introduced in-line particle size analysis at the milling stage noticed significantly less over-milling. Hence seeing as much as a 2% increase in plant throughput. In-line elemental analysis allows petrochemical companies to closely monitor Fe, Ni, V which destroy expensive catalysts.
Why incorporate in-line analysis?

Real-time monitoring of your batches
Make immediate corrections to poor batches
Prevent wastage
Improve your manufacturing …

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Insitec, Laser Diffraction, Mastersizer, Meet the Experts, Particle size »

[5 Oct 2017 | ]

The heavy cost of mining and minerals manufacturing
The importance of minerals as a production resource applies to many facets of our daily lives. For instance, the quality of concrete determines the smoothness of a road surface and the sturdiness of a building. However, with the ever-growing demands for quality cement, many have spurred manufacturing processes leading to hefty costs. Such costs incurred comes from wastage when having to reproduce cement because it does not meet the quality standard.
Based on a mechanical and civil engineering study, 6-15% of construction costs …

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Dynamic Light Scattering, Particle size, Tech Talk, Zetasizer »

[26 Sep 2017 | ]

Is there a maximum viscosity for DLS measurements?
 
The Malvern Zetasizer can determine particle size by dynamic light scattering (DLS). In this technique, the intensity fluctuations are analyzed to find the corresponding diffusion coefficient that led to the fluctuations. The translational diffusion coefficient Dt of a particle is inversely related to its size and the viscosity of the dispersant (or more accurately the hydrodynamic radius rH and viscosity η).
This relationship can be used to predict detectability limits of the technique in general, and this is how we explore the idea of …

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Archimedes, Binding affinity and Kd, Chemical identification, Differential Scanning Calorimetry, Dynamic Light Scattering, Gel permeation chromatography, Image Analysis, Label-free analysis, MicroCal, Microcalorimetry, Morphologi G3-ID, Nanoparticle Tracking Analysis, Nanosight, Particle concentration, Particle shape, Particle size, Protein Aggregation, Protein higher order structure, Raman spectroscopy, Resonant mass measurement, Rheological and Viscosity, Size Exclusion Chromatography, Taylor Dispersion Analysis, Tech Talk, Viscosizer TD, Viscotek, Zetasizer »

[21 Sep 2017 | ]

I know this sounds like the beginning of a bad joke, but in this case, it was actually the beginning of the 2017 Colorado Protein Stability Conference, held in July at Beaver Run Resort in Breckenridge, Colorado. In attendance was a range of scientists and researchers from all over the world, with one common subject in mind: Protein Stability.

One of the highlights of this conference was the pre-conference workshop. This was a free workshop for all attendees of the conference, which was sponsored by Malvern Panalytical. The workshop included a range …

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Customer experience, Dynamic Light Scattering, Particle size, Zeta potential, Zetasizer »

[22 Aug 2017 | ]

Zetasizer: 21CFR? Electronic Record/Electronic Signature? Test Schedule?
 

The Malvern Zetasizer is an extremely versatile measurement system. By far the most systems are used in academic and industry research laboratories, for example in fundamental research, drug discovery, or formulation optimization. However, a significant number of installations are in operation in “controlled” environments, such as for quality control in pharmaceutical companies. Here documentation and compliance with good manufacturing standards GMP is critically important, and a specific version of the operating software exist that locks down standard operating procedures (SOP) with limited ability (based …

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Dynamic Light Scattering, Electrophoretic light scattering, Laser Diffraction, Particle size, Zeta potential, Zetasizer »

[3 Aug 2017 | ]

Intralipid-Lipid emulsions

Lipid emulsions are administered intravenously for a variety of purposes:

To help feed patients with temporary difficulty in ingesting food orally
For better transport of lipophilic drugs (fat-friendly active ingredient (API) which is not soluble in water)
For controlled release of drugs (size related to uptake and retention)
To decreasing adverse reactions to drugs
To improve targeting of drugs
In emerging gene therapies for cellular and gene delivery, and personalized medicine

Control and understanding of colloidal properties – such as droplet size and zeta potential – enable the design and optimization of appropriately stable emulsions. The …

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Laser Diffraction, Mastersizer, Particle size, Tech Talk »

[1 Aug 2017 | ]

Just when I thought I’d seen everything that could contaminate the background, a user sent me this picture! The Musca Domestica (common housefly) was attracted by certain aromatics used in testing and seems to have entered the measurement cell through an empty Hydro EV over a weekend. Unfortunately, it became wedged within the measurement cell and did not survive the experience.

The most important message from the Mastersizer training courses I give is to make sure you have a good background before you start. Laser diffraction is a background subtracted technique: …

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Customer experience, Dynamic Light Scattering, Meet the Experts, Particle size, Zetasizer »

[20 Jun 2017 | ]

Three methods to verify dynamic light scattering systems
If you are a meticulous researcher you may want to test your new Zetasizer. Is it really providing the correct size? One of the advantages of dynamic light scattering is that there are no tweakable adjustments, it is all physics: laser wave length, scattering angle, refractive index of the dispersant are all known in advance and are given parameters for the optical setup and sample. Nevertheless, it is a good idea to check and verify the performance of the system. One of the …

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Laser Diffraction, Mastersizer, Meet the Experts, Particle size, Tech Talk »

[13 Jun 2017 | ]

I recently presented a webinar exploring the practical aspects of sieving method – the advantages and disadvantages.  I compared the method to other techniques such as laser diffraction indicating the increased wealth of information that can be obtained with these more modern instrumental techniques and the common pitfalls and assumptions of the screening technique.
More than 800 of you registered for the webinar and I received a large numbers of interesting questions which I have been working steadily through. I thought it would be a good idea to share the questions and answers via the blog, so here they …

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Archimedes, Customer experience, Differential Scanning Calorimetry, Gel permeation chromatography, Image Analysis, MicroCal, Morphologi G3-ID, Nanoparticle Tracking Analysis, Nanosight, Particle size, Protein Aggregation, Raman spectroscopy, Resonant mass measurement, Viscotek »

[1 Jun 2017 | ]

Our key driver at Malvern Instruments is to create technologies that make a difference or solve a problem, and working hand-in-hand with our customers enables us to make sure that’s exactly what’s happening, out in the field.  We place a high value on our collaborations and partnerships with customers from a wide range of industries and organizations across the globe and love to see how our systems are being used in real-world scenarios.  This gives us vital feedback on what we’re doing well, and also any tweaks we need to make in order to optimize …

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Meet the Experts, Particle size, Tech Talk »

[30 May 2017 | ]

On April 26th, 2017, I had the great pleasure of being invited to talk as part of the very first Malvern TEDx evening, held at the Coachhouse Theatre in Great Malvern.  It was a really enjoyable event, and the talks are now on YouTube for you all to view!

I gave a top-level overview of how so many of the products and devices we consume or encounter on a daily basis are specifically designed by chemists and other scientists, so that they work the way we need or want them to. From …

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Customer experience, Dynamic Light Scattering, Electrophoretic light scattering, Molecular size, Particle size, Zeta potential, Zetasizer »

[25 May 2017 | ]

A challenge to all new Zetasizers!
 
The Zetasizer is so simple to use that the majority of Zetasizer (user)s just “dive in” and find out how to operate the system.
By design it is (almost) indestructable, so what can go wrong? Not much – nevertheless, you might be able to get even more use and benefit from your system with a little preparation.
 
Free eLearning video – really!
If you are relatively new to the Zetasizer then take a look at our free eLearning introductory course. It was meant as a teaser for the …

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Archimedes, Chemical identification, Fluorescence Detection, Label-free analysis, Malvern Panalytical Events, MicroCal, Microcalorimetry, Molecular size, Molecular structure, Molecular weight, Morphologi G3-ID, Nanosight, Particle concentration, Particle shape, Particle size, Protein Aggregation, Protein higher order structure, Protein Mobility, Viscosizer TD, Zeta potential, Zetasizer »

[16 May 2017 | ]

With Pre-Conference Workshop on Biophysical Characterization and Particle Analysis
 

Date: July 17th – 20th.
We at Malvern know that protein stability is important in numerous disciplines, ranging from basic and medical biochemistry to pharmaceutical sciences. However, it is rare that researchers from all the relevant areas can join to discuss the critical issues in the field. The 2017 Colorado Protein Stability Conference provides a unique forum for this exchange of information. The topics to be covered include protein folding, dynamics and thermodynamic stability; amyloidosis and protein aggregation; and stability, formulation, analysis and processing …

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Customer experience, Dynamic Light Scattering, Molecular size, Particle size, Zeta potential, Zetasizer »

[4 May 2017 | ]

3 stumbling blocks for Report Designer (Zetasizer) – the rule of two
The three most common holdups encountered in the report designer feature are listed here.
Not everyone delves into the depth of the Zetasizer software, but of those who do want to take advantage of the report customization features in the ‘report designer’ nearly everyone runs into at least one of these three common mistakes:

1. Folder locations – there are two!
The Zetasizer software is typically installed in a (hidden) Windows directory like  C:\Program Files\Malvern Instruments\Zetasizer Software and that’s good. However, if …

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Français, Insitec, Laser Diffraction, Malvern Panalytical Events, Meet the Experts, Particle shape, Particle size »

[2 May 2017 | ]

Malvern organise des formations en collaboration avec la société SDTech Micro et SDTech Nano, son partenaire technique depuis 7 ans.

SDTech Micro, situé à Alès, est spécialisé dans l’analyse et le traitement à façon des poudres fines et ultrafines.
La semaine derniere, SDtech organisait les journees techniques avec Glatt et Malvern. Des présentations théoriques s’enchainerent avec des ateliers sur un granulateur Glatt en mode “granulation” le premier jour puis en mode “enrobage” le deuxième jour.

 

En parallèle une démonstration de broyage sur un microniseur à jet d’air contrôlé entièrement par un granulomètre laser …

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Malvern Panalytical Events, Meet the Experts, Particle size »

[20 Apr 2017 | ]

The food industry is extremely diverse (‘we are what we eat’) and requires the understanding and control of specific characterization attributes to impact final product quality. From measuring particle size to bulk properties, our seminar will help you to improve product consistency and the ability to engineer the products for different markets/tastes with a wide range of complementary technologies and application expertise.
 
Malvern’s free one-day seminar is ideal for those in product formulation, QA/QC, and manufacturing who are looking to gain an overview of some of the ways to understand formulations …

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Français, Insitec, Laser Diffraction, Meet the Experts, Parsum, Particle size, Spatial Filter Velocimetry »

[23 Mar 2017 | ]

“Lit d’air fluidisé : Granulation, Enrobage et Encapsulation”

Malvern, leader en caractérisation des particules, SDTech Micro, expert des poudres fines, et son partenaire technique Glatt, leader mondial en lit d’air fluidisé, organisent deux journées techniques pour aborder les enjeux et les nouveautés technologiques des procédés de granulation, d’enrobage et d’encapsulation en lit d’air fluidisé. Rappels théoriques et ateliers pratiques sont au programme.
THEMATIQUES :
25 avril :

Présentation de SDTech et de Glatt
Lit d’air fluidisé, techniques et technologies
De la poudre aux grains, caractérisation
1er atelier : Granulation en lit d’air fluidisé

26 avril :

Sécurité des poudres …

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Dynamic Light Scattering, Molecular size, Particle concentration, Particle size, Protein Aggregation, Tech Talk, Zetasizer »

[7 Mar 2017 | ]

How can I use DLS for sample xyz?
What sample concentration / refractive index is needed for reliable DLS size measurements?

Has it been done before?
In Dynamic Light Scattering (DLS) intensity fluctuations in the sample are analyzed to obtain size information on the sample. The technique is applicable to a wide size range from sub-nanometer up to a few microns. In order to obtain a meaningful result, a minimum scattering signal strength must be present. Malvern’s Zetasizer Nano software contains a calculator to help estimate the required minimum concentration.
If anyone else has …

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Binding affinity and Kd, Differential Scanning Calorimetry, Dynamic Light Scattering, Français, Gel permeation chromatography, Image Analysis, Isothermal Titration Calorimetry, Laser Diffraction, Meet the Experts, Molecular size, Nanoparticle Tracking Analysis, Particle concentration, Particle size, Rheological and Viscosity, Rheometry - Rotational, Size Exclusion Chromatography, Static Light Scattering, Zeta potential »

[21 Feb 2017 | ]

Afin de vous apporter un support concret pour utiliser votre système de façon optimale, finaliser vos bonnes pratiques de laboratoire et répondre à vos besoins spécifiques, Malvern organise des formations sur site ou en sessions dans nos 3 agences françaises (Orsay, Lyon et Toulouse).
Voici les dates de toutes les sessions programmées pour 2017 :
CARACTERISATION DES PARTICULES PAR DIFFRACTION LASER
Objectifs : Perfectionner les méthodes de caractérisation des particules en voie sèche et liquide, définir les bonnes pratiques de laboratoire et s’adapter aux besoins spécifiques de chaque installation. Comprendre le principe physique …

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Meet the Experts, Molecular weight, OMNISEC, Particle size, Tech Talk, Zeta potential, Zetasizer »

[30 Jan 2017 | ]

Malvern Instruments takes part at the 8th International Symposium on the Separation and Characterization of Natural and Synthetic Macromolecules (SCM-8) at Rhone Events & Congrescenter. The main interest of the conference is the separation and characterization of large molecules. The target audience includes specialists from analytical chemistry, polymer science, and life-science communities.
Malvern is a sponsor of the conference so keep an eye out for us at our booth. In addition, I will give a talk on Thursday February, 2nd about ‘Combining Multi-Detector GPC Measurements with Ultra-High Performance GPC Separations’. The …

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