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Phase quantification

X-ray powder diffraction is a powerful technique for the quantitative determination of the crystalline phases in a mixture. Typical applications include the quantification of minerals for grade control of rocks and ores, clinker and cement phases in building material industries, and bath ratio or ‘potflux’ analysis in aluminum smelters. XRD is suitable for quality control. The method is for example used by the pharmaceutical industry to detect and quantify small amounts of impurities such as unwanted polymorphs in a sample, and by universities and research institutes to classify the purity of synthesized materials.

Crystal Structure Determination, Empyrean, Phase identification, Phase quantification, Tech Talk, X-Ray Diffraction (XRD), X-Ray Scattering »

[24 May 2018 | ]

Detection of trace polymorphs, determination of amorphous content, and the study of the stability of active pharmaceutical ingredients (APIs) subjected to heat and humidity are some of the many applications where a modern powder X-ray diffraction (PXRD) system can add value to drug development.  Advances in beam conditioning and detector technology have led to greatly improved detection limits, resolution, and range of applications now possible. Today’s modern, laboratory-based PXRD instrumentation and advanced software can greatly assist pharmaceutical scientists in their quest to develop high quality, stable products and accelerate their …

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