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Zeta potential

The benefits of using zeta potential measurements to improve formulation stability and shelf life and reduce formulation time and cost.

Electrophoretic light scattering, Malvern Panalytical Events, Meet the Experts, Molecular size, Nanoparticle Tracking Analysis, Nanosight, Particle concentration, Particle size, Zeta potential, Zetasizer »

[19 Jun 2018 | ]

I presented a new webinar focusing on “A basic introduction to Electrophoretic Light Scattering (ELS)“. In this presentation, I explained the importance of Zeta potential measurements for colloidal dispersions and how it is determined using ELS.
As you certainly know, Electrophoretic Light Scattering (ELS) is a technique used to measure the electrophoretic mobility of particles or molecules in solution. This measurement is used to determine Zeta potential, which is a measure of the electrostatic or charges repulsion/attraction between particles and is a predictor of emulsion and dispersion stability. Zeta potential is …

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Dynamic Light Scattering, Meet the Experts, Zeta potential, Zetasizer »

[14 Jun 2018 | ]

Have you ever tried to explain to someone that the large peak they can see in their dynamic light scattering data, that seems to dominate the size distribution by intensity – is actually only a very tiny part of the sample…and hardly ‘there’ at all?
This has happened to me on numerous occasions, and I always try to show the volume and number size distributions, illustrating how that peak disappears. However, there is often a lingering question hanging in the air: “But if we see it, then it’s there, right?”
In the …

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Customer experience, Dynamic Light Scattering, Malvern Panalytical Events, Meet the Experts, Nanoparticle Tracking Analysis, Nanosight, Particle concentration, Zeta potential, Zetasizer »

[5 Jun 2018 | ]

Malvern Panalytical Webinars

 
Don’t miss the live launch of the new Empyrean on July 11th
We’re ready to unveil a revolution in the world of X-ray diffraction: we proudly present our new 3rd generation Empyrean diffractometer, introducing the newly developed MultiCore Optics.
In addition, join our free Lunch & Learn Seminar on Monday, July 2nd at the EPDIC Conference in Edinburgh, UK.(Kirkland room – 12.30-2.00pm) where Empyrean’s Product Manager Fabio Masiello will enlighten you about our 3rd generation Empyrean platform.
Here is the list of what’s coming up in the coming weeks. You can …

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Dynamic Light Scattering, Electrophoretic light scattering, Particle size, Tech Talk, Zeta potential, Zetasizer »

[31 May 2018 | ]

How good can a gold standard be?
 
When performing dynamic light scattering (DLS) measurements, we sometimes encounter especially nice data. An interesting issue to consider is the level of data quality one can expect to achieve, under ideal circumstances, when all other interferences are minimized. This is especially relevant at the smaller nanoscale where fewer standards are available, and to those who have less practical experience with sizing colloidal nanoparticles by DLS. How monodisperse can a good sample be? What are achievable polydispersity index (PDI) values to aspire to?
What is the …

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Corporate, Dynamic Light Scattering, Electrophoretic light scattering, Molecular size, Molecular weight, Particle concentration, Particle size, Zeta potential, Zetasizer »

[23 May 2018 | ]

Where is the Zetasizer used?
 
For around two decades, the Zetasizer range has been the de facto standard for performing dynamic light scattering (DLS) measurements on a wide range of particles and materials.
Today’s launch of the Zetasizer Pro and Zetasizer Ultra – which took place earlier today on May 23rd, 2018 – provides a good reason to summarize the key application areas for light scattering technology: both dynamic and electrophoretic! Where are these Zetasizers used? Where can we find them, in the real world?
Below is a list of key application focus areas:

Bioscience and biopharmaceuticals: …

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Elemental analysis, Empyrean, Epsilon, Français, Image Analysis, Malvern Panalytical Events, Mastersizer, Meet the Experts, Particle shape, Particle size, X'Pert3, X-Ray Diffraction (XRD), X-Ray Fluorescence (XRF), Zeta potential »

[22 Mar 2018 | ]

Malvern Panalytical sera à Forum Labo Biotech Lyon, Stand A12, (en bas des escalators) les 28 et 29 mars 2018. Forum Labo est le salon des fournisseurs de matériels et services pour le laboratoire.
Venez voir en exclusivité le nouveau granulomètre et analyseur de forme Morphologi 4 ainsi que 3 autres nouveaux instruments inédits !
Vous pourrez découvrir :

Un nouveau rhéomètre avec de nouvelles fonctionnalités,
Des passeurs d’échantillons pour Zetasizer, Nanosight NS300,

Un nouveau spectromètre de fluorescence X Epsilon 4 de la gamme Panalytical.

Toute notre équipe de spécialistes d’application sera présente, prête à répondre à toutes vos questions …

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Dynamic Light Scattering, Malvern Panalytical Events, Meet the Experts, Zeta potential, Zetasizer »

[15 Mar 2018 | ]

Dynamic Light Scattering (DLS), sometimes referred to as Photon Correlation Spectroscopy or Quasi-Elastic Light Scattering, is a technique classically used for measuring the size of particles typically in the sub-micron region, dispersed in a liquid. The sensitivity of some modern systems is such that it can also now be used to measure the size of macromolecules in solution.
In this new webinar, I summarise how the technique works, what its size and concentration limits are and discuss its advantages and disadvantages.
This webinar was well-attended and I received several questions, I thought …

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Electrophoretic light scattering, Tech Talk, Zeta potential, Zetasizer »

[6 Mar 2018 | ]

Will the zeta potential of my vesicles vary in different buffers?
 

The short answer is: Yes, it will. In select cases, the value of the measured zeta potential may remain close to the same. However, that is the exception rather than the rule. This is no different for vesicles than for other nanoparticles, biomolecules, polyelectrolytes, etc.
How does zeta change with salt concentration?
The zeta potential of a colloidal particle in solution is a description of the overall effective net charge of the particle under the sample system conditions. Thus the effective net …

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Dynamic Light Scattering, Gel permeation chromatography, Kinexus, Laser Diffraction, Malvern Panalytical Events, Meet the Experts, Molecular weight, Nanoparticle Tracking Analysis, Nanosight, OMNISEC, Particle concentration, Particle size, Rheology, Rheometry, Tech Talk, Viscotek, Zeta potential, Zetasizer »

[30 Jan 2018 | ]

We will be attending Pittcon 2018 in Orlando, Florida Feb 26th – Mar 1st and once again we are pleased to feature a number of our recognized characterization experts who will be presenting a variety of short courses throughout the week.
Time is running out, so don’t miss out on the early bird deadline for discounted admission which ends on February 5th.
Below is a listing of our available short course offerings.
We look forward to seeing you in Orlando at one of our short courses and our Booths #2118 & #2119.
Monday, February 26th
Fundamentals of Particle …

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Dynamic Light Scattering, Electrophoretic light scattering, Inside Malvern Panalytical, Zeta potential, Zetasizer »

[21 Dec 2017 | ]

On the 20th December 1977 (40 years ago) the Royal Radar and Signals Establishment (RRSE) and Malvern Instruments received the coveted MacRobert Award for the development of the Malvern Correlator.  This was fundamental to the development of Photon Correlation Spectroscopy (PCS) and the evolution of the Zetasizer product line. The MacRobert award is the UK’s longest-running and most prestigious national prize for engineering innovation. Other past winners include engineers behind innovations such as the Pegasus jet engine, catalytic converters, the roof of the Millennium Dome and intelligent prosthetic limbs.
The concept …

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Electrophoretic light scattering, Tech Talk, Zeta potential, Zetasizer »

[5 Sep 2017 | ]

Zetasizer: What is the zeta potential deviation?
 
The Malvern Zetasizer software report for zeta potential shows a parameter that is called Zeta deviation. This parameter is shown directly below the mean Zeta potential.

The mean zeta potential is derived from the fast field reversal (FFR) phase analysis light scattering (PALS) technique.
The fast field reversal provides a single number from the analysis. This single number is the mean zeta potential. The slow field reversal [also known as SFR] can be used to determine the zeta distribution, a distribution of different charge values from …

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Customer experience, Dynamic Light Scattering, Particle size, Zeta potential, Zetasizer »

[22 Aug 2017 | ]

Zetasizer: 21CFR? Electronic Record/Electronic Signature? Test Schedule?
 

The Malvern Zetasizer is an extremely versatile measurement system. By far the most systems are used in academic and industry research laboratories, for example in fundamental research, drug discovery, or formulation optimization. However, a significant number of installations are in operation in “controlled” environments, such as for quality control in pharmaceutical companies. Here documentation and compliance with good manufacturing standards GMP is critically important, and a specific version of the operating software exist that locks down standard operating procedures (SOP) with limited ability (based …

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Dynamic Light Scattering, Electrophoretic light scattering, Laser Diffraction, Particle size, Zeta potential, Zetasizer »

[3 Aug 2017 | ]

Intralipid-Lipid emulsions

Lipid emulsions are administered intravenously for a variety of purposes:

To help feed patients with temporary difficulty in ingesting food orally
For better transport of lipophilic drugs (fat-friendly active ingredient (API) which is not soluble in water)
For controlled release of drugs (size related to uptake and retention)
To decreasing adverse reactions to drugs
To improve targeting of drugs
In emerging gene therapies for cellular and gene delivery, and personalized medicine

Control and understanding of colloidal properties – such as droplet size and zeta potential – enable the design and optimization of appropriately stable emulsions. The …

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Electrophoretic light scattering, Meet the Experts, Protein Mobility, Zeta potential, Zetasizer »

[27 Jul 2017 | ]

Nanomaterial isoelectric points IEPs
 
In a recent webinar presented by Ana Morfesis titled “Characterizing the zeta potential & Isoelectric Point of Nanomaterials” we got such a good turnout that we were not able to address the numerous questions asked during the event.
Thank you for the participation!
Since there was such strong interest, we have provided the following list of questions and answers to benefit all who are interested.  We have also provided a table of common metal oxide IEPs, as shown to the left.
 
 
For those who were not able to attend the live event, the session was recorded and is …

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Customer experience, Dynamic Light Scattering, Electrophoretic light scattering, Molecular size, Particle size, Zeta potential, Zetasizer »

[25 May 2017 | ]

A challenge to all new Zetasizers!
 
The Zetasizer is so simple to use that the majority of Zetasizer (user)s just “dive in” and find out how to operate the system.
By design it is (almost) indestructable, so what can go wrong? Not much – nevertheless, you might be able to get even more use and benefit from your system with a little preparation.
 
Free eLearning video – really!
If you are relatively new to the Zetasizer then take a look at our free eLearning introductory course. It was meant as a teaser for the …

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Archimedes, Chemical identification, Label-free analysis, Malvern Panalytical Events, MicroCal, Microcalorimetry, Molecular size, Molecular structure, Molecular weight, Morphologi, Nanosight, Particle concentration, Particle shape, Particle size, Protein Aggregation, Protein Mobility, Viscosizer TD, Zeta potential, Zetasizer »

[16 May 2017 | ]

With Pre-Conference Workshop on Biophysical Characterization and Particle Analysis
 

Date: July 17th – 20th.
We at Malvern know that protein stability is important in numerous disciplines, ranging from basic and medical biochemistry to pharmaceutical sciences. However, it is rare that researchers from all the relevant areas can join to discuss the critical issues in the field. The 2017 Colorado Protein Stability Conference provides a unique forum for this exchange of information. The topics to be covered include protein folding, dynamics and thermodynamic stability; amyloidosis and protein aggregation; and stability, formulation, analysis and processing …

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Customer experience, Dynamic Light Scattering, Molecular size, Particle size, Zeta potential, Zetasizer »

[4 May 2017 | ]

3 stumbling blocks for Report Designer (Zetasizer) – the rule of two
The three most common holdups encountered in the report designer feature are listed here.
Not everyone delves into the depth of the Zetasizer software, but of those who do want to take advantage of the report customization features in the ‘report designer’ nearly everyone runs into at least one of these three common mistakes:

1. Folder locations – there are two!
The Zetasizer software is typically installed in a (hidden) Windows directory like  C:\Program Files\Malvern Instruments\Zetasizer Software and that’s good. However, if …

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Dynamic Light Scattering, Electrophoretic light scattering, Meet the Experts, Static Light Scattering, Zeta potential, Zetasizer »

[16 Mar 2017 | ]

Recently, I hosted a webinar which discussed what surface zeta potential is and how it can be measured. The webinar attracted huge interest and it was a pleasure to see so many people attending and asking some excellent questions. In fact, there were so many questions asked, that we ran out of time at the end of the webinar and had to answer many of them via e-mail. Some of these are listed below.
The webinar discussed the zeta potential of solid, planar surfaces (rather than colloidal dispersions or molecular solutions) …

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Français, Meet the Experts, Zeta potential, Zetasizer »

[13 Mar 2017 | ]

Les deuxièmes ateliers de l’IFTS (Institut de Filtration et des Techniques Séparatives) auront lieu les 15 et 16 mars à Foulayronnes (près d’Agen).
Cette année, ces ateliers seront dédiés à la caractérisation des boues et suspensions.
Le mercredi 15 mars, de 15H15 à 15H30, Michel Terray et Alain Blasco présenteront le Zetasizer WT, appareil pour la mesure en ligne du potentiel zêta lors d’une conférence intitulée “Process control of water treatment and filtration by zeta potential measurement” contenant :

Intérêt du potentiel zêta dans le suivi de floculation
Exemple d’application chez Wemlinger et Severn Trent Water
Retour d’expérience basé sur …

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Binding affinity and Kd, Differential Scanning Calorimetry, Dynamic Light Scattering, Français, Gel permeation chromatography, Image Analysis, Isothermal Titration Calorimetry, Laser Diffraction, Meet the Experts, Molecular size, Nanoparticle Tracking Analysis, Particle concentration, Particle size, Rheology, Rheometry, Size Exclusion Chromatography, Static Light Scattering, Zeta potential »

[21 Feb 2017 | ]

Afin de vous apporter un support concret pour utiliser votre système de façon optimale, finaliser vos bonnes pratiques de laboratoire et répondre à vos besoins spécifiques, Malvern organise des formations sur site ou en sessions dans nos 3 agences françaises (Orsay, Lyon et Toulouse).
Voici les dates de toutes les sessions programmées pour 2017 :
CARACTERISATION DES PARTICULES PAR DIFFRACTION LASER
Objectifs : Perfectionner les méthodes de caractérisation des particules en voie sèche et liquide, définir les bonnes pratiques de laboratoire et s’adapter aux besoins spécifiques de chaque installation. Comprendre le principe physique …

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