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Electrophoretic light scattering, Meet the Experts, Protein Mobility, Zeta potential, Zetasizer »

[27 Jul 2017 | ]

Nanomaterial isoelectric points IEPs
 
In a recent webinar presented by Ana Morfesis titled “Characterizing the zeta potential & Isoelectric Point of Nanomaterials” we got such a good turnout that we were not able to address the numerous questions asked during the event.
Thank you for the participation!
Since there was such strong interest, we have provided the following list of questions and answers to benefit all who are interested.  We have also provided a table of common metal oxide IEPs, as shown to the left.
 
 
For those who were not able to attend the live event, the session was recorded and is …

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Differential Scanning Calorimetry, Dynamic Light Scattering, Meet the Experts, MicroCal, Molecular size, Molecular weight, OMNISEC, Particle concentration, Protein Aggregation, Size Exclusion Chromatography, Taylor Dispersion Analysis, Zetasizer »

[18 Jul 2017 | ]

Monoclonal Antibodies – or mAbs for short

Since many of these mAbs require refrigeration we had used dynamic light scattering (with a Zetasizer) to show the formation of aggregates after freeze-thaw cycles (for details see application note “Effect of storage conditions on Immunoglobulin“). These could be seen both in the increased polydispersity index (PDI) and the appearance of a large-size aggregate peak in the intensity size distribution as shown to the right. The area under the peak gives an indication of the presence of the large aggregates but is not suited for …

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Malvern Events, Meet the Experts »

[6 Jul 2017 | ]

Malvern Webinars

This summer, we have a number of webinars scheduled that you may want to register for including presentations on protein and rheological characterization techniques, and the basics of Nanoparticle Tracking Analysis.  We will also walk you through the basic day-to-day operation of Archimedes in the latest edition of our popular “Demo at your desk” series.
Coming up in July:
11th – Viscosizer TD – protein stability characterization platform
Scientists working in early-stage development within the Biopharmaceutical industry. Those interested in assessing molecular size, stability and self-association, as well as relative viscosity of proteins, peptides and small …

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Differential Scanning Calorimetry, Meet the Experts, MicroCal, Microcalorimetry, Protein higher order structure »

[4 Jul 2017 | ]

Protein Antigens and DSC

This blog highlights two recent articles that focus on the use of a MicroCal Differential Scanning Calorimetry (DSC) system.
Differential Scanning Calorimetry – A Method for Assessing the Thermal Stability and Conformation of Protein Antigen
I.B. Duruwoju, K.M. Bhandal, J. Hu, B. Carpick, and M. Kirkitadze
Journal of Visualized Experiments (JoVE), Issue 121, e55262, doi:10.3791/55262 (2017)
The authors (from Sanofi Pasteur in Toronto, Canada), provide a detailed protocol to perform Differential Scanning Calorimetry experiments on an automated DSC, such as a MicroCal VP-Capillary DSC system from Malvern Instruments.  This piece is a JoVE …

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Kinexus, Meet the Experts, Rheological and Viscosity, Rheometry - Rotational »

[27 Jun 2017 | ]

Last year I went on a rheology tour!! I gave 12 talks in 10 days in 7 locations around Australia and New Zealand, talking primarily about suspension rheology and how particle characteristics such as particle size and shape affect rheology.
I spoke about the stability of suspensions and the factor to consider when assessing suspension stability but another major focus was the viscoelastic properties of materials.
Viscoelasticity: A material that possesses both liquid and solid-like properties which may change depending on how we handle and treat it.
One great example of a viscoelastic material is pitch, asphalt or bitumen …

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Customer experience, Dynamic Light Scattering, Meet the Experts, Particle size, Zetasizer »

[20 Jun 2017 | ]

Three methods to verify dynamic light scattering systems
If you are a meticulous researcher you may want to test your new Zetasizer. Is it really providing the correct size? One of the advantages of dynamic light scattering is that there are no tweakable adjustments, it is all physics: laser wave length, scattering angle, refractive index of the dispersant are all known in advance and are given parameters for the optical setup and sample. Nevertheless, it is a good idea to check and verify the performance of the system. One of the …

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Laser Diffraction, Mastersizer, Meet the Experts, Particle size, Tech Talk »

[13 Jun 2017 | ]

I recently presented a webinar exploring the practical aspects of sieving method – the advantages and disadvantages.  I compared the method to other techniques such as laser diffraction indicating the increased wealth of information that can be obtained with these more modern instrumental techniques and the common pitfalls and assumptions of the screening technique.
More than 800 of you registered for the webinar and I received a large numbers of interesting questions which I have been working steadily through. I thought it would be a good idea to share the questions and answers via the blog, so here they …

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Meet the Experts, Particle size, Tech Talk »

[30 May 2017 | ]

On April 26th, 2017, I had the great pleasure of being invited to talk as part of the very first Malvern TEDx evening, held at the Coachhouse Theatre in Great Malvern.  It was a really enjoyable event, and the talks are now on YouTube for you all to view!

I gave a top-level overview of how so many of the products and devices we consume or encounter on a daily basis are specifically designed by chemists and other scientists, so that they work the way we need or want them to. From …

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Dynamic Light Scattering, Meet the Experts, Taylor Dispersion Analysis, Tech Talk, Viscosizer TD, Zetasizer »

[18 May 2017 | ]

Matt McGann and I will be representing Malvern at the upcoming annual UD Biophysical Characterization Workshop, sponsored by CBST (Center for Biomanufacturing Science & Technology), BITC (Biomolecular Interaction Technologies Center), and the University of Delaware, on June 6, 2017, hosted by Professor Christopher Roberts.
This year’s workshop will consist of three days of short courses and small-group demonstrations of the principles and commercial technologies for characterization of protein solutions and related colloidal systems, focusing specifically on static and dynamic light scattering, electrophoresis (DLS, ELS), and Taylor Dispersion Analysis (TDA).
Matt has been …

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Differential Scanning Calorimetry, Isothermal Titration Calorimetry, Meet the Experts, MicroCal, Microcalorimetry »

[11 May 2017 | ]

In September 2016 Malvern Instruments co-organized a European MicroCal meeting with Institut Pasteur and ARBRE European molecular biophysics network. The meeting was very successful and sparked animated discussions during scientific presentations, panel and poster sessions and interactive workshops.  A key focus was on best practice for experimental design and data analysis to ensure high-quality data and informed decisions that help drive scientific projects forward.
In two days, together with more than 120 participants from 19 countries, we covered a wide range of topics, from interaction and kinetic analysis with ITC to …

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Kinexus, Meet the Experts, Rheological and Viscosity, Rheometry - Rotational »

[9 May 2017 | ]

Controlling the performance of an ink is a complex optimization challenge. Understanding how features of the system, the dispersed particle size in particular, impact stability and behavior during each stage of the printing process is crucial for effective formulation.
Over the past 30 years, the use of commercial and industrial inks has changed substantially. In particular, the maturation of inkjet technology has revolutionized printing. From office printers through to industrial coding and marking systems, inks are now required to meet demanding performance targets, for a wide range of different applications.
Inks are …

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Français, Insitec, Laser Diffraction, Malvern Events, Meet the Experts, Particle shape, Particle size »

[2 May 2017 | ]

Malvern organise des formations en collaboration avec la société SDTech Micro et SDTech Nano, son partenaire technique depuis 7 ans.

SDTech Micro, situé à Alès, est spécialisé dans l’analyse et le traitement à façon des poudres fines et ultrafines.
La semaine derniere, SDtech organisait les journees techniques avec Glatt et Malvern. Des présentations théoriques s’enchainerent avec des ateliers sur un granulateur Glatt en mode “granulation” le premier jour puis en mode “enrobage” le deuxième jour.

 

En parallèle une démonstration de broyage sur un microniseur à jet d’air contrôlé entièrement par un granulomètre laser …

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Malvern Events, Meet the Experts, Particle size »

[20 Apr 2017 | ]

The food industry is extremely diverse (‘we are what we eat’) and requires the understanding and control of specific characterization attributes to impact final product quality. From measuring particle size to bulk properties, our seminar will help you to improve product consistency and the ability to engineer the products for different markets/tastes with a wide range of complementary technologies and application expertise.
 
Malvern’s free one-day seminar is ideal for those in product formulation, QA/QC, and manufacturing who are looking to gain an overview of some of the ways to understand formulations …

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Kinexus, Malvern Events, Meet the Experts, Rheological and Viscosity, Rheometry - Rotational »

[6 Apr 2017 | ]

This week is the Annual European Rheology Conference (AERC) held in beautiful Copenhagen. It has been a great conference so far with the opening reception at the City Hall – what an impressive building.

Malvern had a talk on Tuesday with our very own Nordic Rheology Specialist, Mats Larsson, talking about how “Creep testing can be used as an alternative to multi wave oscillation for determining the true gel point of network polymers“.
The session was appropriately chaired by Professor Henning Winter who along with Francois Chambon set out the criterion for …

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Français, Insitec, Laser Diffraction, Meet the Experts, Parsum, Particle size, Spatial Filter Velocimetry »

[23 Mar 2017 | ]

“Lit d’air fluidisé : Granulation, Enrobage et Encapsulation”

Malvern, leader en caractérisation des particules, SDTech Micro, expert des poudres fines, et son partenaire technique Glatt, leader mondial en lit d’air fluidisé, organisent deux journées techniques pour aborder les enjeux et les nouveautés technologiques des procédés de granulation, d’enrobage et d’encapsulation en lit d’air fluidisé. Rappels théoriques et ateliers pratiques sont au programme.
THEMATIQUES :
25 avril :

Présentation de SDTech et de Glatt
Lit d’air fluidisé, techniques et technologies
De la poudre aux grains, caractérisation
1er atelier : Granulation en lit d’air fluidisé

26 avril :

Sécurité des poudres …

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Malvern Events, Meet the Experts »

[20 Mar 2017 | ]

Pittcon 2017, as it has in previous years, provided us with an excellent opportunity to meet with current and prospective customers to discuss their application challenges and introduce them to some of our technologies.
The Malvern team spent the week engaged with customers, both in the short courses we offered as well as at our booth, discussing applications and characterization challenges.
 
For many visitors, Pittcon provided their first opportunity to see certain Malvern instruments in person. There was significant interest at the booth for our Mastersizer 3000, OMNISEC, NanoSight, and Zetasizer, and overall …

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Dynamic Light Scattering, Electrophoretic light scattering, Meet the Experts, Static Light Scattering, Zeta potential, Zetasizer »

[16 Mar 2017 | ]

Recently, I hosted a webinar which discussed what surface zeta potential is and how it can be measured. The webinar attracted huge interest and it was a pleasure to see so many people attending and asking some excellent questions. In fact, there were so many questions asked, that we ran out of time at the end of the webinar and had to answer many of them via e-mail. Some of these are listed below.
The webinar discussed the zeta potential of solid, planar surfaces (rather than colloidal dispersions or molecular solutions) …

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Archimedes - Particle Metrology System, Malvern Events, Meet the Experts, MicroCal, OMNISEC, Viscosizer TD »

[14 Mar 2017 | ]

Malvern Instruments is known for particle sizing technologies. Did you know that many of our instruments are used to characterize proteins, nucleic acids, liposomes, exosomes, and other biomolecules?
Our instruments are used in academic and government research labs, as well as pharmaceutical and biotech companies.
In North America, we have a team of field application scientists and sales consultants who are focused on biomolecule characterization using microcalorimetry, light scattering, Taylor dispersion analysis, nanoparticle tracking analysis, resonant mass measurement, and size-exclusion chromatography.
In the upcoming months, Malvern representatives are attending the scientific conferences listed …

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Français, Meet the Experts, Zeta potential, Zetasizer »

[13 Mar 2017 | ]

Les deuxièmes ateliers de l’IFTS (Institut de Filtration et des Techniques Séparatives) auront lieu les 15 et 16 mars à Foulayronnes (près d’Agen).
Cette année, ces ateliers seront dédiés à la caractérisation des boues et suspensions.
Le mercredi 15 mars, de 15H15 à 15H30, Michel Terray et Alain Blasco présenteront le Zetasizer WT, appareil pour la mesure en ligne du potentiel zêta lors d’une conférence intitulée “Process control of water treatment and filtration by zeta potential measurement” contenant :

Intérêt du potentiel zêta dans le suivi de floculation
Exemple d’application chez Wemlinger et Severn Trent Water
Retour d’expérience basé sur …

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Binding affinity and Kd, Differential Scanning Calorimetry, Dynamic Light Scattering, Français, Gel permeation chromatography, Image Analysis, Isothermal Titration Calorimetry, Laser Diffraction, Meet the Experts, Molecular size, Nanoparticle Tracking Analysis, Particle concentration, Particle size, Rheological and Viscosity, Rheometry - Rotational, Size Exclusion Chromatography, Static Light Scattering, Zeta potential »

[21 Feb 2017 | ]

Afin de vous apporter un support concret pour utiliser votre système de façon optimale, finaliser vos bonnes pratiques de laboratoire et répondre à vos besoins spécifiques, Malvern organise des formations sur site ou en sessions dans nos 3 agences françaises (Orsay, Lyon et Toulouse).
Voici les dates de toutes les sessions programmées pour 2017 :
CARACTERISATION DES PARTICULES PAR DIFFRACTION LASER
Objectifs : Perfectionner les méthodes de caractérisation des particules en voie sèche et liquide, définir les bonnes pratiques de laboratoire et s’adapter aux besoins spécifiques de chaque installation. Comprendre le principe physique …

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