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Dynamic Light Scattering, Malvern Panalytical Events, Meet the Experts, Zeta potential, Zetasizer »

[15 Mar 2018 | ]

Dynamic Light Scattering (DLS), sometimes referred to as Photon Correlation Spectroscopy or Quasi-Elastic Light Scattering, is a technique classically used for measuring the size of particles typically in the sub-micron region, dispersed in a liquid. The sensitivity of some modern systems is such that it can also now be used to measure the size of macromolecules in solution.
In this new webinar, I summarise how the technique works, what its size and concentration limits are and discuss its advantages and disadvantages.
This webinar was well-attended and I received several questions, I thought …

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Meet the Experts, Nanoparticle Tracking Analysis, Nanosight, Particle concentration »

[1 Mar 2018 | ]

I am excited that the Sample Assistant autosampler for the NanoSight NS300 was recently launched as we are get increasing numbers of requests for automated NTA analyses. The full launch webinar is available showing the system in operation and the user interfaces.
Having worked with several of the beta test sites, I can see how valuable this accessory will be in the field. Many of our users are testing increasing numbers of samples, some to the point where a person is essentially full time testing samples on the NanoSight system. On one …

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Aeris, ASD, Claisse, Epsilon, Malvern Panalytical Events, Meet the Experts, Morphologi, OMNISEC, Zetasizer »

[20 Feb 2018 | ]

This year will be the 19th Pittcon in a row that I have attended (there should be an award for that, right?). Actually, Malvern Panalytical did receive an award from Pittcon 11 years ago for our then 50th anniversary of attending the conference.  If you still have not made it to this annual gathering of the latest in laboratory equipment, educational courses and technical presentations galore, here are some reasons to consider heading to Orlando on February 26 (or Philadelphia in 2019):
1 – You can see the latest in analytical …

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Customer experience, Dynamic Light Scattering, Malvern Panalytical Events, Meet the Experts, Nanoparticle Tracking Analysis, Nanosight, Particle concentration, Zeta potential, Zetasizer »

[2 Feb 2018 | ]

Malvern Panalytical Webinars

As our webinars are quite popular, we decided to include the Q&A for some of them. You can easily access them in the list of On Demand webinars. Stay tuned to our blog as more webinar Q&As are on their way!
Here is the full list of the latest Malvern Panalytical webinars that have been presented (including ASD Inc. and Claisse).

A basic introduction to Dynamic Light Scattering (DLS) for particle size analysis
A basic introduction to Electrophoretic Light Scattering (ELS) for Zeta potential measurements
Precision Agriculture & Groundtruthing using Spectral Signatures


The NanoSight …

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2830 ZT, 3D structure / imaging, Contaminant detection and analysis, Elemental analysis, Elemental quantification, Epsilon, Meet the Experts, X-Ray Fluorescence (XRF), Zetium »

[1 Feb 2018 | ]

For quality and process control many elemental analysis techniques are available. Let’s see how ICP, AAS, ICP-MS, ICP-OES and X-ray fluorescence spectroscopy (XRF) stack up are traditional techniques used in many industries. Each of these techniques has a number of advantages and disadvantages giving the analyst the flexibility to choose which technology suits best. When the required limits of quantification are above 1 ppm (µg/g), or when the non-destructive analysis is required, XRF is a very attractive technique that should be considered, especially when analyzing solids, powders, slurries, filters, and …

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Dynamic Light Scattering, Gel permeation chromatography, Kinexus, Laser Diffraction, Malvern Panalytical Events, Meet the Experts, Molecular weight, Nanoparticle Tracking Analysis, Nanosight, OMNISEC, Particle concentration, Particle size, Rheology, Rheometry, Tech Talk, Viscotek, Zeta potential, Zetasizer »

[30 Jan 2018 | ]

We will be attending Pittcon 2018 in Orlando, Florida Feb 26th – Mar 1st and once again we are pleased to feature a number of our recognized characterization experts who will be presenting a variety of short courses throughout the week.
Time is running out, so don’t miss out on the early bird deadline for discounted admission which ends on February 5th.
Below is a listing of our available short course offerings.
We look forward to seeing you in Orlando at one of our short courses and our Booths #2118 & #2119.
Monday, February 26th
Fundamentals of Particle …

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Français, Kinexus, Meet the Experts, Rheology, Rheometry »

[17 Jan 2018 | ]

Lors du 52ème Congrès du Groupe Français de Rhéologie (GFR), Guillaume Ovarlez (Directeur de recherche au CNRS, Laboratoire du Futur CNRS-Solvay, Pessac, France) a reçu le prix Maurice Couette et présenté ses travaux sur les inhomogénéités dans les écoulements de suspensions concentrées pour lesquels des rhéomètres de la gamme Kinexus ont été utilisés.
Monsieur Ovarlez a notamment expliqué que la rhéométrie classique fonctionnait très bien dès lors que les matériaux étudiés sont homogènes et que l’écoulement et lui aussi homogène. Cependant la structure des suspensions et leur écoulement peuvent s’influencer.
Ainsi, les …

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Image Analysis, Meet the Experts, Morphologi, Particle shape, Particle size »

[28 Dec 2017 | ]

After a break of 4 years, it was great to get back to the Drug Delivery to the Lungs conference (DDL2017) in Edinburgh this year. After the snow and gales of previous years when I have visited it was rather quiet in terms of weather this year, but not in terms of content as this was varied and interesting. I caught up on some of the latest advances in inhaled device development targeting special populations, such as small children or critically ill patients. It was really exciting to see the …

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Borate fusion, Claisse, Meet the Experts, X-Ray Fluorescence (XRF) »

[19 Dec 2017 | ]

What is fusion?
You might already know that the choice of the sample preparation method for X-Ray Fluorescence (XRF) or Inductively Coupled Plasma (ICP) atomic emission spectroscopy analysis is critical to obtain precise and accurate results with the spectrometer.
Have you ever heard about fusion? Let’s demystify this technique and have a look at its benefits when compared to pressed pellets.
What is it exactly?
Fusion for XRF analysis consists of mixing a ground sample with a borate flux (lithium or sodium) inside a 95% platinum / 5% gold crucible, heating around 1000 °C with …

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CNA, Meet the Experts, Pulsed Fast Thermal Neutron Activation (PFTNA), X-Ray Fluorescence (XRF), Zetium »

[12 Dec 2017 | ]

A while ago I attended the mining conference Exponor in Antofagasta, Chile and found it to be an immense, mostly open-air display and the technical program aimed at keeping the South American mines informed of the latest solutions for all aspects of their industry. In and amongst the huge mining machinery and vendors of everything – from dust masks to helicopters – was Malvern Panalytical. One trend did emerge from the people we did get to talk to at this event – a common theme of looking for ways to improve efficiency. This …

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ASD, Ground truthing, Image Analysis, Meet the Experts, Near-InfraRed spectroscopy (NIR), Remote sensing »

[30 Nov 2017 | ]

The ASD FieldSpec 4 Hi-Res NG provides enhanced spectral resolution to support accurate calibration and image classification analysis.
Higher resolution hyperspectral sensors yield greater precision for remote sensing classification applications, producing more information from every pixel generated in an image than ever before. In order to take advantage of the full potential of these sensors, measurements from ground-based instrumentation need to meet or exceed the sensor’s spectral resolution. In the absence of this resolution equality, data are interpolated during post-processing; as a result, vital spectral information can be smoothed and lost.
The enhanced spectral resolution …

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Epsilon, Meet the Experts, X-Ray Fluorescence (XRF) »

[21 Nov 2017 | ]

Whether it is for mineral exploration or mining waste analysis, there is a time lapse between bringing samples back to the laboratory, analysis and making decisions in the field.
Increasingly, governments are focusing on protecting the environment. Companies can be charged with hefty environmental fines. Minimise your company’s risk through quick analysis of undesirable environmental waste elements.
Imagine if you could have the flexibility to react quickly by analyzing samples while traveling between mine sites. Here’s a tip on how to set up a mobile lab in your car with the Epsilon …

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Français, Insitec, Laser Diffraction, Malvern Panalytical Events, Meet the Experts, Particle size »

[15 Nov 2017 | ]

Le Salon des technologies des solides et liquides en vrac

Nous serons présents sur le Salon Vrac Tech du 28 au 30 novembre 2017 – Hall C – Stand A19.
Vous pourrez découvrir nos granulomètres laser pour contrôler vos procédés de fabrication de poudres jusqu’à 1 mm et des sondes pour mesurer des granulés en ligne jusqu’à 6 mm. En effet, le contrôle des procédés de broyage intéresse et concerne de plus en plus d’usines de l’industrie alimentaire.
Rejoignez nous et demandez votre badge!
Informations pratiques :
Parc des Expositions du Mans
1, Avenue du Parc des Expositions
72100 Le Mans
Coordonnées …

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Binding affinity and Kd, Isothermal Titration Calorimetry, Meet the Experts, MicroCal, Microcalorimetry »

[12 Oct 2017 | ]

Isothermal Titration Calorimetry
Molecular recognition is key in all biological processes and cellular responses. It is critical to characterize the structural and thermodynamic forces behind the recognition and specificity of macromolecular interactions in order to understand the molecular events in a cell. Several biophysical techniques (including fluorescence, circular dichroism, Fourier transform infrared spectroscopy, mass spectroscopy, surface plasmon resonance, and microscale thermophoresis) are used to characterize non-covalent molecular interactions.
Isothermal titration calorimetry (ITC) has become a popular and versatile bioanalytical method for the direct measurement of binding affinity between interacting molecules.  ITC instruments were …

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Insitec, Laser Diffraction, Mastersizer, Meet the Experts, Particle size »

[5 Oct 2017 | ]

The heavy cost of mining and minerals manufacturing
The importance of minerals as a production resource applies to many facets of our daily lives. For instance, the quality of concrete determines the smoothness of a road surface and the sturdiness of a building. However, with the ever-growing demands for quality cement, many have spurred manufacturing processes leading to hefty costs. Such costs incurred comes from wastage when having to reproduce cement because it does not meet the quality standard.
Based on a mechanical and civil engineering study, 6-15% of construction costs …

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Chemical identification, Image Analysis, Meet the Experts, Morphologi, Particle shape, Raman spectroscopy »

[29 Sep 2017 | ]

I have just come back from presenting my talk ‘Application of Morphologically-Directed Raman Spectroscopy in deformulation and in vitro bioequivalence studies’ at the pharma focus session of Powtech 2017.
The talk indicated how there are still many drug products that have come of patent but do not yet have generic equivalents available and how there is a drive from the regulatory bodies to make health care more accessible and so they are producing many guidance documents to help address this.
I gave an overview of a proposed workflow for developing generic drug …

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Chemical identification, Image Analysis, Meet the Experts, Morphologi, Particle shape »

[7 Sep 2017 | ]

Standing at just under 3800 m tall with its distinctive symmetrical cone-shaped peak, the majestic Mount Fuji, or Fujisan (富士山) as it is known locally, is one of the most iconic symbols of Japan.
Therefore, it seemed only appropriate that whilst on secondment in Malvern’s Tokyo application lab, I should attempt to reach the summit of this famous volcano and, in something of a cliché, watch the sunrise from the highest peak in the Land of the Rising Sun.
There is only a short window each year in which one is permitted …

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Meet the Experts, Nanoparticle Tracking Analysis, Nanosight, Particle concentration »

[24 Aug 2017 | ]

I recently presented a webinar titled “Basic Principles of Nanoparticle Tracking Analysis: Size, Concentration and Speciation with Single-Particle Resolution”. We got such a good turnout that we were not able to address the numerous questions asked during the event.
Thank you for the participation!

Since there was such strong interest, we have provided the following list of questions and answers to benefit all who are interested.
Q: In DLS also we can get lognormal number distribution. How is the NTA number distribution different?
NTA yields a number weighted distribution because it is a particle …

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Electrophoretic light scattering, Meet the Experts, Protein Mobility, Zeta potential, Zetasizer »

[27 Jul 2017 | ]

Nanomaterial isoelectric points IEPs
In a recent webinar presented by Ana Morfesis titled “Characterizing the zeta potential & Isoelectric Point of Nanomaterials” we got such a good turnout that we were not able to address the numerous questions asked during the event.
Thank you for the participation!
Since there was such strong interest, we have provided the following list of questions and answers to benefit all who are interested.  We have also provided a table of common metal oxide IEPs, as shown to the left.
For those who were not able to attend the live event, the session was recorded and is …

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Differential Scanning Calorimetry, Dynamic Light Scattering, Meet the Experts, MicroCal, Molecular size, Molecular weight, OMNISEC, Particle concentration, Protein Aggregation, Size Exclusion Chromatography, Taylor Dispersion Analysis, Zetasizer »

[18 Jul 2017 | ]

Monoclonal Antibodies – or mAbs for short

Since many of these mAbs require refrigeration we had used dynamic light scattering (with a Zetasizer) to show the formation of aggregates after freeze-thaw cycles (for details see application note “Effect of storage conditions on Immunoglobulin“). These could be seen both in the increased polydispersity index (PDI) and the appearance of a large-size aggregate peak in the intensity size distribution as shown to the right. The area under the peak gives an indication of the presence of the large aggregates but is not suited for …

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