Home » Archive

Meet the Experts

Binding affinity and Kd, Isothermal Titration Calorimetry, Meet the Experts, MicroCal, Microcalorimetry »

[12 Oct 2017 | ]

Isothermal Titration Calorimetry
Molecular recognition is key in all biological processes and cellular responses. It is critical to characterize the structural and thermodynamic forces behind the recognition and specificity of macromolecular interactions in order to understand the molecular events in a cell. Several biophysical techniques (including fluorescence, circular dichroism, Fourier transform infrared spectroscopy, mass spectroscopy, surface plasmon resonance, and microscale thermophoresis) are used to characterize non-covalent molecular interactions.
Isothermal titration calorimetry (ITC) has become a popular and versatile bioanalytical method for the direct measurement of binding affinity between interacting molecules.  ITC instruments were …

Read the full story »

Insitec, Laser Diffraction, Mastersizer, Meet the Experts, Particle size »

[5 Oct 2017 | ]

The heavy cost of mining and minerals manufacturing
The importance of minerals as a production resource applies to many facets of our daily lives. For instance, the quality of concrete determines the smoothness of a road surface and the sturdiness of a building. However, with the ever-growing demands for quality cement, many have spurred manufacturing processes leading to hefty costs. Such costs incurred comes from wastage when having to reproduce cement because it does not meet the quality standard.
Based on a mechanical and civil engineering study, 6-15% of construction costs …

Read the full story »

Chemical identification, Image Analysis, Meet the Experts, Morphologi G3-ID, Particle shape, Raman spectroscopy »

[29 Sep 2017 | ]

I have just come back from presenting my talk ‘Application of Morphologically-Directed Raman Spectroscopy in deformulation and in vitro bioequivalence studies’ at the pharma focus session of Powtech 2017.
The talk indicated how there are still many drug products that have come of patent but do not yet have generic equivalents available and how there is a drive from the regulatory bodies to make health care more accessible and so they are producing many guidance documents to help address this.
I gave an overview of a proposed workflow for developing generic drug …

Read the full story »

Chemical identification, Image Analysis, Meet the Experts, Morphologi G3, Morphologi G3-ID, Particle shape »

[7 Sep 2017 | ]

Standing at just under 3800 m tall with its distinctive symmetrical cone-shaped peak, the majestic Mount Fuji, or Fujisan (富士山) as it is known locally, is one of the most iconic symbols of Japan.
Therefore, it seemed only appropriate that whilst on secondment in Malvern’s Tokyo application lab, I should attempt to reach the summit of this famous volcano and, in something of a cliché, watch the sunrise from the highest peak in the Land of the Rising Sun.
There is only a short window each year in which one is permitted …

Read the full story »

Malvern Panalytical Events, Meet the Experts »

[29 Aug 2017 | ]

Malvern Webinars

We are now in September and here is our new list of live webinars coming this month. We’ve got some really good speakers such as Professor Henning Winter from the University of Massachusetts and the director of Martin Warman Consultancy.
As our webinars are so popular, we decided to include the Q&A for some of them. You can easily access them in the list of On Demand webinars. Stay tune in our blog as more webinars Q&A are on their way!
Coming up in September:
14th – Rheology of Soft Matter – …

Read the full story »

Meet the Experts, Nanoparticle Tracking Analysis, Nanosight, Particle concentration »

[24 Aug 2017 | ]

I recently presented a webinar titled “Basic Principles of Nanoparticle Tracking Analysis: Size, Concentration and Speciation with Single-Particle Resolution”. We got such a good turnout that we were not able to address the numerous questions asked during the event.
Thank you for the participation!

Since there was such strong interest, we have provided the following list of questions and answers to benefit all who are interested.
Q: In DLS also we can get lognormal number distribution. How is the NTA number distribution different?
NTA yields a number weighted distribution because it is a particle …

Read the full story »

Electrophoretic light scattering, Meet the Experts, Protein Mobility, Zeta potential, Zetasizer »

[27 Jul 2017 | ]

Nanomaterial isoelectric points IEPs
 
In a recent webinar presented by Ana Morfesis titled “Characterizing the zeta potential & Isoelectric Point of Nanomaterials” we got such a good turnout that we were not able to address the numerous questions asked during the event.
Thank you for the participation!
Since there was such strong interest, we have provided the following list of questions and answers to benefit all who are interested.  We have also provided a table of common metal oxide IEPs, as shown to the left.
 
 
For those who were not able to attend the live event, the session was recorded and is …

Read the full story »

Differential Scanning Calorimetry, Dynamic Light Scattering, Meet the Experts, MicroCal, Molecular size, Molecular weight, OMNISEC, Particle concentration, Protein Aggregation, Size Exclusion Chromatography, Taylor Dispersion Analysis, Zetasizer »

[18 Jul 2017 | ]

Monoclonal Antibodies – or mAbs for short

Since many of these mAbs require refrigeration we had used dynamic light scattering (with a Zetasizer) to show the formation of aggregates after freeze-thaw cycles (for details see application note “Effect of storage conditions on Immunoglobulin“). These could be seen both in the increased polydispersity index (PDI) and the appearance of a large-size aggregate peak in the intensity size distribution as shown to the right. The area under the peak gives an indication of the presence of the large aggregates but is not suited for …

Read the full story »

Differential Scanning Calorimetry, Meet the Experts, MicroCal, Microcalorimetry, Protein higher order structure »

[4 Jul 2017 | ]

Protein Antigens and DSC

This blog highlights two recent articles that focus on the use of a MicroCal Differential Scanning Calorimetry (DSC) system.
Differential Scanning Calorimetry – A Method for Assessing the Thermal Stability and Conformation of Protein Antigen
I.B. Duruwoju, K.M. Bhandal, J. Hu, B. Carpick, and M. Kirkitadze
Journal of Visualized Experiments (JoVE), Issue 121, e55262, doi:10.3791/55262 (2017)
The authors (from Sanofi Pasteur in Toronto, Canada), provide a detailed protocol to perform Differential Scanning Calorimetry experiments on an automated DSC, such as a MicroCal VP-Capillary DSC system from Malvern Instruments.  This piece is a JoVE …

Read the full story »

Kinexus, Meet the Experts, Rheological and Viscosity, Rheometry - Rotational »

[27 Jun 2017 | ]

Last year I went on a rheology tour!! I gave 12 talks in 10 days in 7 locations around Australia and New Zealand, talking primarily about suspension rheology and how particle characteristics such as particle size and shape affect rheology.
I spoke about the stability of suspensions and the factor to consider when assessing suspension stability but another major focus was the viscoelastic properties of materials.
Viscoelasticity: A material that possesses both liquid and solid-like properties which may change depending on how we handle and treat it.
One great example of a viscoelastic material is pitch, asphalt or bitumen …

Read the full story »

Customer experience, Dynamic Light Scattering, Meet the Experts, Particle size, Zetasizer »

[20 Jun 2017 | ]

Three methods to verify dynamic light scattering systems
If you are a meticulous researcher you may want to test your new Zetasizer. Is it really providing the correct size? One of the advantages of dynamic light scattering is that there are no tweakable adjustments, it is all physics: laser wave length, scattering angle, refractive index of the dispersant are all known in advance and are given parameters for the optical setup and sample. Nevertheless, it is a good idea to check and verify the performance of the system. One of the …

Read the full story »

Laser Diffraction, Mastersizer, Meet the Experts, Particle size, Tech Talk »

[13 Jun 2017 | ]

I recently presented a webinar exploring the practical aspects of sieving method – the advantages and disadvantages.  I compared the method to other techniques such as laser diffraction indicating the increased wealth of information that can be obtained with these more modern instrumental techniques and the common pitfalls and assumptions of the screening technique.
More than 800 of you registered for the webinar and I received a large numbers of interesting questions which I have been working steadily through. I thought it would be a good idea to share the questions and answers via the blog, so here they …

Read the full story »

Meet the Experts, Particle size, Tech Talk »

[30 May 2017 | ]

On April 26th, 2017, I had the great pleasure of being invited to talk as part of the very first Malvern TEDx evening, held at the Coachhouse Theatre in Great Malvern.  It was a really enjoyable event, and the talks are now on YouTube for you all to view!

I gave a top-level overview of how so many of the products and devices we consume or encounter on a daily basis are specifically designed by chemists and other scientists, so that they work the way we need or want them to. From …

Read the full story »

Dynamic Light Scattering, Meet the Experts, Taylor Dispersion Analysis, Tech Talk, Viscosizer TD, Zetasizer »

[18 May 2017 | ]

Matt McGann and I will be representing Malvern at the upcoming annual UD Biophysical Characterization Workshop, sponsored by CBST (Center for Biomanufacturing Science & Technology), BITC (Biomolecular Interaction Technologies Center), and the University of Delaware, on June 6, 2017, hosted by Professor Christopher Roberts.
This year’s workshop will consist of three days of short courses and small-group demonstrations of the principles and commercial technologies for characterization of protein solutions and related colloidal systems, focusing specifically on static and dynamic light scattering, electrophoresis (DLS, ELS), and Taylor Dispersion Analysis (TDA).
Matt has been …

Read the full story »

Differential Scanning Calorimetry, Isothermal Titration Calorimetry, Meet the Experts, MicroCal, Microcalorimetry »

[11 May 2017 | ]

In September 2016 Malvern Instruments co-organized a European MicroCal meeting with Institut Pasteur and ARBRE European molecular biophysics network. The meeting was very successful and sparked animated discussions during scientific presentations, panel and poster sessions and interactive workshops.  A key focus was on best practice for experimental design and data analysis to ensure high-quality data and informed decisions that help drive scientific projects forward.
In two days, together with more than 120 participants from 19 countries, we covered a wide range of topics, from interaction and kinetic analysis with ITC to …

Read the full story »

Kinexus, Meet the Experts, Rheological and Viscosity, Rheometry - Rotational »

[9 May 2017 | ]

Controlling the performance of an ink is a complex optimization challenge. Understanding how features of the system, the dispersed particle size in particular, impact stability and behavior during each stage of the printing process is crucial for effective formulation.
Over the past 30 years, the use of commercial and industrial inks has changed substantially. In particular, the maturation of inkjet technology has revolutionized printing. From office printers through to industrial coding and marking systems, inks are now required to meet demanding performance targets, for a wide range of different applications.
Inks are …

Read the full story »

Français, Insitec, Laser Diffraction, Malvern Panalytical Events, Meet the Experts, Particle shape, Particle size »

[2 May 2017 | ]

Malvern organise des formations en collaboration avec la société SDTech Micro et SDTech Nano, son partenaire technique depuis 7 ans.

SDTech Micro, situé à Alès, est spécialisé dans l’analyse et le traitement à façon des poudres fines et ultrafines.
La semaine derniere, SDtech organisait les journees techniques avec Glatt et Malvern. Des présentations théoriques s’enchainerent avec des ateliers sur un granulateur Glatt en mode “granulation” le premier jour puis en mode “enrobage” le deuxième jour.

 

En parallèle une démonstration de broyage sur un microniseur à jet d’air contrôlé entièrement par un granulomètre laser …

Read the full story »

Malvern Panalytical Events, Meet the Experts, Particle size »

[20 Apr 2017 | ]

The food industry is extremely diverse (‘we are what we eat’) and requires the understanding and control of specific characterization attributes to impact final product quality. From measuring particle size to bulk properties, our seminar will help you to improve product consistency and the ability to engineer the products for different markets/tastes with a wide range of complementary technologies and application expertise.
 
Malvern’s free one-day seminar is ideal for those in product formulation, QA/QC, and manufacturing who are looking to gain an overview of some of the ways to understand formulations …

Read the full story »

Kinexus, Malvern Panalytical Events, Meet the Experts, Rheological and Viscosity, Rheometry - Rotational »

[6 Apr 2017 | ]

This week is the Annual European Rheology Conference (AERC) held in beautiful Copenhagen. It has been a great conference so far with the opening reception at the City Hall – what an impressive building.

Malvern had a talk on Tuesday with our very own Nordic Rheology Specialist, Mats Larsson, talking about how “Creep testing can be used as an alternative to multi wave oscillation for determining the true gel point of network polymers“.
The session was appropriately chaired by Professor Henning Winter who along with Francois Chambon set out the criterion for …

Read the full story »

Français, Insitec, Laser Diffraction, Meet the Experts, Parsum, Particle size, Spatial Filter Velocimetry »

[23 Mar 2017 | ]

“Lit d’air fluidisé : Granulation, Enrobage et Encapsulation”

Malvern, leader en caractérisation des particules, SDTech Micro, expert des poudres fines, et son partenaire technique Glatt, leader mondial en lit d’air fluidisé, organisent deux journées techniques pour aborder les enjeux et les nouveautés technologiques des procédés de granulation, d’enrobage et d’encapsulation en lit d’air fluidisé. Rappels théoriques et ateliers pratiques sont au programme.
THEMATIQUES :
25 avril :

Présentation de SDTech et de Glatt
Lit d’air fluidisé, techniques et technologies
De la poudre aux grains, caractérisation
1er atelier : Granulation en lit d’air fluidisé

26 avril :

Sécurité des poudres …

Read the full story »