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Malvern Panalytical technologies are used by scientists and engineers in a wide range of industries and organizations to solve the challenges associated with maximizing productivity, developing better quality products and getting them to market faster.

Chemical identification, Corporate, Dynamic Light Scattering, Electrophoretic light scattering, Morphologi, Particle shape, Raman spectroscopy, Zeta potential, Zetasizer »

[20 Sep 2018 | ]

Guest blog written by Chris Langley, Senior Sector Manager at DCA Design International Ltd.
Malvern Panalytical in conjunction with DCA recently received two awards for the Morphologi (4 and 4ID) and Zetasizer (Ultra and Pro) at the prestigious Red Dot 2018 product design awards. The distinction ‘Red Dot‘ is recognized internationally as one of the most sought-after seals of quality for good design.
The Red Dot Award jury comprises some 40 experts from around the world, who discuss, evaluate and test every single entry, live and on site, in a process lasting several …

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Gel permeation chromatography, Molecular weight, OMNISEC, Size Exclusion Chromatography »

[19 Sep 2018 | ]

Determining which gel permeation/size exclusion chromatography (GPC/SEC) system is best for your needs can be a daunting task. Even after you’ve decided to include a light scattering detector to obtain absolute molecular weight data you’re still left to choose between two options: a multi-angle light scattering (MALS) detector or a right angle and low angle light scattering detector (RALS/LALS). Both light scattering configurations will provide the absolute molecular weight of a sample but utilize different approaches toward that common goal. Fortunately, Malvern Panalytical offers both; the modular SEC-MALS 20 unit …

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Aeris, Customer experience, X-Ray Diffraction (XRD) »

[18 Sep 2018 | ]

In their own words, Louis C. Herring & Co. president Glenn Austin and lab supervisor David Fletcher talk about the recent addition of an Aeris X-ray diffractometer to their lab. The Aeris replaces a 1980’s vintage PW1840 benchtop X-Ray Diffraction (XRD) system – a classic product from Malvern Panalytical’s long history of XRD innovation.

In business for over 60 years, Luis C. Herring & Co. is a kidney stone analysis laboratory serving doctors throughout the country and beyond. Glenn spoke the importance of high-quality XRD analysis to their analyses. He stated …

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ASD, FieldSpec, Ground truthing, LabSpec, Near-InfraRed spectroscopy (NIR), QualitySpec, Remote sensing, TerraSpec »

[13 Sep 2018 | ]

Malvern Panalytical’s ASD brand offers a comprehensive variety of spectroscopy accessories to meet a multitude of near-infrared (NIR) materials analysis application requirements. Enjoy the ASD approach of one affordable customized instrument combined with one or more accessories for adaptation to your application needs.
The ASD probes and accessories listed below represent just some of our more popular options; contact us  for a comprehensive list.

 

Fiber Optic Illuminator
A portable, external light source designed for use with ASD LabSpec and TerraSpec instruments, and sampling accessories that do not have a built-in light source.

 

Contact Probe 
Designed for …

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Gel permeation chromatography, Molecular structure, Molecular weight, OMNISEC, Size Exclusion Chromatography »

[12 Sep 2018 | ]

When thinking about a reason to purchase a particular piece of scientific equipment, you want to know not only that you are getting the best piece of kit, but also that you’ll be maximizing the return on your investment.  Manufacturers like Malvern Panalytical can add value to their products in a variety of ways, and one is the support and materials you’ll get to help you make the most of your purchase.  In this blog, I want to tell you about the additional benefits and added value that you’ll receive …

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Binding affinity and Kd, Differential Scanning Calorimetry, MicroCal, Tech Talk »

[11 Sep 2018 | ]

This blog answers FAQs on the new Automated and Manual MicroCal PEAQ-DSC systems. For more information, check your user manual, or contact your regional Malvern Panalytical Support.
 
 
 
Q: How much sample do I need to fill the MicroCal PEAQ-DSC cell?
For the MicroCal Automated PEAQ-DSC, you need to have at least 325 μL of the sample or buffer in the appropriate well of the 96-well plate. This is the default setting for the experimental setup. 300 μL is removed by the filling syringe.
You can use a larger sample volume (up to 400 μL)  and …

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Borate fusion, Claisse, Tech Talk, X-Ray Fluorescence (XRF) »

[6 Sep 2018 | ]

Platinumware is used in sample preparation by fusion for XRF and ICP analysis. Crucibles (used for XRF and ICP analysis) and molds (only used for XRF) are made of 95% Pt and 5% Au.
Why use platinum and gold?
It has been proven that this alloy has a high melting point and can withstand extreme heat. Platinum has a great thermal conductivity and ensures very low contamination of the molten mixture during fusion. The addition of gold has a non-wetting effect. In short, the alloy of these two precious metals allows the …

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Customer experience, Electrophoretic light scattering, Meet the Experts, Zeta potential, Zetasizer »

[5 Sep 2018 | ]

How can we obtain the applied field strength?
When performing electrophoretic light scattering (ELS) measurements, the sample is exposed to an externally applied electric field, and we observe the extra movement that the particles undergo as a result of the applied field with the changes in the phase difference between the un-scattered reference laser beam and the scattering from the particles. The electrophoretic mobility µ is the particle velocity v divided by the electric field strength E, where the field strength is the applied voltage over the distance between the electrodes [typically …

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Crystal Structure Determination, Empyrean, Phase identification, Phase quantification, Tech Talk, X'Pert³, X-Ray Diffraction (XRD) »

[4 Sep 2018 | ]

Since I made my first steps in the powder diffraction community, I have been amazed by the many possibilities for collecting diffractograms. In this blog, I’ll describe how I learned about the advantages of transmission geometry over reflection geometry for specific samples.
In almost every powder diffractometer, the reflection geometry is being used: the detector is at the same side of the sample surface.
This geometry works very well for inorganic materials that can be prepared as flat samples with randomly oriented crystallites.
One of the disadvantages of reflection geometry is that it …

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Customer experience, Dynamic Light Scattering, Malvern Panalytical Events, Meet the Experts, Nanoparticle Tracking Analysis, Nanosight, Particle concentration, Zeta potential, Zetasizer »

[30 Aug 2018 | ]

Malvern Panalytical Webinars

Here is the list of the upcoming webinars in the coming weeks. You can register for free to all our webinars and you will automatically receive the On Demand version if you can’t finally attend the live event directly in your inbox!
September
 
6th – Quality by Design: Principles for pharmaceutical method development
Steve Ward-Smith will outline what QbD is, how it works within pharmaceutical development, and will provide some examples of the ‘fishbone’ diagrams which show the factors that should be considered when developing methods for laser diffraction and dynamic light scattering.
11th – Adaptive Correlation: …

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ASD, Customer experience, FieldSpec, Ground truthing, LabSpec, Near-InfraRed spectroscopy (NIR), QualitySpec, Remote sensing, TerraSpec »

[29 Aug 2018 | ]

ASD, a Malvern Panalytical brand, began hosting a webinar series initiative back in 2016, whereby some of our well known ASD instrument users and customers have shared and discussed their various and diverse application uses involving an ASD VNIR spectrometer or spectroradiometer.
From Mars, wine, and malt barley to snow, mosquitoes, and postmortem bones – here is a look back at the interesting applications that have made up ASD’s webinar series (click on the image to watch the webinar on-demand!):

Click below to learn more about ASD and view our ASD products!
 

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Image Analysis, Morphologi, Tech Talk »

[28 Aug 2018 | ]

How the development of automated test scripts has increased test coverage and improved the overall quality of the software on the Morphologi 4 and 4-ID
My role as the Software Test Engineer of the Morphologi team is to ensure that changes made to the software meet the acceptance criteria and the high-quality standards of the overall software are still met. I find the work we do at Malvern Panalytical fascinating, however, testing software used for applications like Morphologi 4 and 4-ID has its challenges – the biggest of which is the time required to run …

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Gel permeation chromatography, Molecular structure, Molecular weight, OMNISEC, Size Exclusion Chromatography, Tech Talk »

[22 Aug 2018 | ]

The most common detector in any GPC/SEC instrument is a refractive index (RI) detector.  There are multiple reasons for this, but the most important is because the difference in refractive index between that of a sample solution and that of the same solvent without a sample is directly proportional to the concentration of the sample.  This is why RI detectors are referred to as concentration detectors.  (It should be noted that UV-Vis detectors are also concentration detectors, but require the sample has a chromophore and absorbs light at a detectable …

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ASD, Customer experience, FieldSpec, Ground truthing, Near-InfraRed spectroscopy (NIR), Remote sensing »

[21 Aug 2018 | ]

Analytik, leading suppliers of innovative analytical instrumentation and Malvern Panalytical’s ASD reseller for the United Kingdom and Ireland, share this report on how the ASD FieldSpec® HandHeld 2 spectroradiometer has been used to study the Amazon rainforest.
Dr. Chris Doughty is a former research fellow in tropical forest ecology within the Environmental Change Institute (ECI) at the University of Oxford. 
While at the University of Oxford, Chris described his work and vision where a handheld spectrometer became a vital part of his laboratory on the move. “Our goal was to use leaf spectroscopy …

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Differential Scanning Calorimetry, Label-free analysis, MicroCal, Tech Talk »

[14 Aug 2018 | ]

In a previous blog, I discussed best practices to achieve high-quality data with a MicroCal DSC. Here are more best practices for the MicroCal PEAQ-DSC system, as well as the MicroCal VP-Capillary DSC and VP-DSC systems. These best practices apply to the analysis of proteins in solution, and other biopolymers.
 
 
Sample requirements:

For high-quality Differential Scanning Calorimetry (DSC) data, the samples need to be in desired buffer (pH, salt, excipients, etc.), and the matched buffer is used in the DSC reference cell and for buffer-buffer scans.
Prepare samples in the desired buffer …

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Dynamic Light Scattering, Electrophoretic light scattering, Malvern Panalytical Events, Particle size, Zetasizer »

[9 Aug 2018 | ]

Launching the latest Zetasizer in Mexico!
 
June was a special month at our Mexico City office. We held a specific launch party organized for the latest addition to our Zetasizer family of instruments – the Zetasizer Pro and the Zetasizer Ultra. One of the groundbreaking novelties in the new system is adaptive correlation, a new method to perform dynamic light scattering (DLS) measurements, where rapid correlation functions are classified as being steady state or transient. Steady-state data sets describe particles that are consistently part of the measurement volume and hence characteristic of …

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ASD, Customer experience, FieldSpec, Near-InfraRed spectroscopy (NIR), Remote sensing »

[8 Aug 2018 | ]

Dr. McKenzie Skiles discusses what it means for climate and hydrology studies
PLEASE NOTE! The webinar date has been moved… Dr. McKenzie Skiles presents her research on our upcoming ASD September 27th webinar, “Climate and hydrology studies leveraging ASD VNIR spectral snow albedo measurements.” This webinar will discuss snow applications and the use of Malvern Panalytical’s ASD FieldSpec® spectroradiometer for data measurement and analysis. The article below details some of McKenzie’s snow data collection and collaborative research project efforts out in the field, as presented by Sarah Fecht.

Authored by Sarah Fecht. Sarah is the content manager …

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Dynamic Light Scattering, Malvern Panalytical Events, Molecular size, Nanoparticle Tracking Analysis, Nanosight, Particle concentration, Zetasizer »

[7 Aug 2018 | ]

Workshop of the LOEWE Center for Translational Medicine and Pharmacology
20th September 2018
Campus Riedberg BIOLOGICUM, Lecture hall 1, -1.202
 
As market interest and investment in nanotechnology surges and the requirements for novel formulation strategies continues to grow, the industry is under pressure to provide a detailed characterization of subvisible particle species and their interactions with biological systems.
Formulation development and manufacture of biopharmaceuticals and nanomaterials are lengthy and complex processes with very specific analytical challenges. We know that in order to successfully deliver such therapies to market it is vital to reduce risk as …

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Dynamic Light Scattering, Molecular size, Particle concentration, Particle size, Tech Talk, Zeta potential, Zetasizer »

[2 Aug 2018 | ]

 
Thanks to all who attended the launch webinar for Malvern Panalytical’s new Zetasizer systems, and special thanks to Mike Kaszuba for presenting a clear and interesting overview of the two instruments – we hope you all enjoyed it and found it interesting.

The launch of the Zetasizer Pro and Zetasizer Ultra received a great response and naturally, due to the innovations included in the new systems, lots of questions were sent to us both during and after the webinar. We’ve taken the opportunity to answer the most frequently-asked questions here, in …

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Borate fusion, LeDoser12, Tech Talk, X-Ray Fluorescence (XRF) »

[31 Jul 2018 | ]

The weighing step is of major importance in sample preparation by fusion since it has a direct impact on the analytical results.
Let’s see five best practices to ensure repeatability and productivity while weighing.
REPEATABILITY
Find the right weighing method
There are three weighing methods in sample preparation: sample-to-flux ratio, catch weight and manual weighing. The far best choice is sample-to-flux ratio since it ensures great repeatability and can be performed automatically using LeDoser-12 instrument. With this method, no software correction is required.
Avoid transferring the weighed content into a different container
You should always weigh …

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