The Morphologi G3-ID offers a unique capability, combining the automated static imaging features of the Morphologi G3 with chemical identification of individual particles using Morphologically-Directed Raman Spectroscopy to enable the measurement of component-specific particle size and particle shape distributions.
Customer experience, Morphologi G3-ID »
At Malvern, we love hearing stories from our customers about how they use our technologies to help them better understand and control their products. From time to time we are going to share some of these stories in a feature we have entitled “Customer Spotlight”.
Our very first Customer Spotlight is from Amber Fradkin of the Particle Characterization Core Facility at KBI Biopharma in Boulder, CO. Amber received her Ph.D. in Chemical Engineering within the Pharmaceutical Biotechnology Program, with a specialization in the field of immunogenicity of therapeutic protein aggregates, at the University …
Chemical identification, Image Analysis, Laser Diffraction, Malvern Events, Mastersizer, Morphologi G3-ID, Particle shape, Particle size, Raman spectroscopy »
Over the past week I’ve had a lot of fun working with Malvern’s team in China to deliver a series of seminars designed to help researchers engaged in pharmaceutical product development. These meetings focused on how Malvern’s material characterization systems can help those developing and manufacturing oral solid dose formulations. During the seminar series, we had the privilege of meeting with well over 200 customers, providing us with the chance to learn about the challenges they are facing in product development, as they seek to select APIs and excipients which …Read the full story »
Chemical identification, Image Analysis, Laser Diffraction, Mastersizer, Meet the Experts, Morphologi G3-ID, Particle shape, Particle size, Raman spectroscopy, Tech Talk »
Component-specific Particle Size
Follow that particle!
I’ve always thought it would be great to be the innocent driver in a movie chase scene who has to respond to the hero’s demand to ‘Follow that car’ as they try to keep tabs on the villain. I always imaged that this would unlock the silent racing driver within me, giving me the excuse to forget about speed limits and drive at the limits of my car’s performance. I’d also get the chance to practice my handbrake turns!
Although I have never been engaged in a …
Finally! After what has felt like one of the wettest and longest winters in memory here in the UK, we’re now heading into the long, mellow days of midsummer.
But casting its miserable shadow over the barbecues, school holidays and paddling pools is the dreaded allergy season. As one of the downsides of life in our “green and pleasant land”, during June we are hit hard by the combined impact of pollen from trees, grasses and weeds.
Many of us are now taking a daily antihistamine of some sort, and others …
Image Analysis, Morphologi G3-ID, Particle shape, Particle size, Raman spectroscopy, Tech Talk »
When working with a couple of our Morphologi G3-ID cement customers I have come to realize that cement is an incredibly complex product. Working with one of our customers in the cement industry we wrote an article, published last year in International Cement Review, discussing some of the challenges facing the cement industry and how the Morphologi G3-ID can help face these challenges.
Cements can contain a large number of components including any number of additives to adapt the cement behavior, the size and shape of any of these components can …
Malvern Events, Meet the Experts, Morphologi G3-ID, Particle shape, Particle size, Raman spectroscopy »
Hoax bioterrorism powder attacks are well known in the USA. Once it is established that the powder is not a real threat, the search is on to establish who made the hoax threat, and the clues can be right there in the powder itself. Often artificial sweeteners are used, and whilst bulk Raman analysis can confirm that a powder is dextrose, Morphologically Directed Raman Spectroscopy (MDRS) can help go a step further and identify the specific sweetening agent, and therefore the brand, which may help in the search for the …Read the full story »
Archimedes - Particle Metrology System, Insitec, Laser Diffraction, Malvern Events, Mastersizer, Morphologi G3-ID, Nanosight, Spraytec, Tech Talk, Zetasizer »
As a confirmed space-geek ever since Halley’s Comet in 1986, lasers, or perhaps I should say laser guns in their various forms, have always been a part of my life. I’m not sure if I first met lasers in Star Wars or being fired at Doctor Who by a Dalek. But I do know they made a big impression on me. The lasers of sci-fi are flashy affairs, complete with awesome graphics, sound effects and implausible physics. Perhaps the most iconic being the lightsaber of Luke Skywalker. So I was …Read the full story »
Chemical identification, Customer experience, Morphologi G3-ID, Particle shape, Raman spectroscopy, Tech Talk »
Hello! A few months ago I blogged about my up and coming visit to Australia and I promised to let you know if I made it to the top of the Sydney Harbour bridge – I am not sure where the time as flown to since then but I thought it was about time I let you know how the trip went.
One of the reasons I headed down under was to give 12 seminars; 4 each in Melbourne, Sydney and Brisbane – the team at ATA Scientific did a great …
When I was young, I liked to take things apart to see how they worked. From my dad’s scientific calculators through to my own Scalextric cars and model steam trains, my curiosity always got the better of me as I grappled screwdrivers, pliers and sometimes claw hammers in order to try and find out what was inside. Putting each item back together was never easy though, and often left me with a significant number of ‘spare parts’. Perhaps this experience is why I ended up following a career as a …Read the full story »
Hay fever sufferers, put that tissue away – there is help at hand!
Summer has got off to a flying start in the British Isles, with some fabulously sunny weather enjoyed throughout June. July has brought with it some pretty heavy showers, but we Brits known that’s only to be expected with the tennis underway at Wimbledon! The good news for most of us is that forecasts are looking promising again as we head deeper into July, so hopefully we can continue to relax in the sun, enjoying barbeques and long evening …
The combination of an aging global population and increased urban pollution levels has led to a significant increase in the prevalence of asthma. It has been estimated that 300 million people suffer from the conditional globally, and that poor disease control causes approximately 250,000 deaths per year. Given the impact the disease has, especially within poorer communities, the recent message from the Global Initiative for Asthma (GINA) on World Asthma Day suggested that it was ‘Time to control asthma’.
One of the barriers to asthma control identified by GINA is the …
I am really looking forward to my next trip as it is somewhere I have never been before. The sale of a Morphologi G3-ID in Australia to Southern Cross University has finally given me the opportunity to go and visit which is very exciting!
I will be heading over to give training on the newly installed system at the Southern Cross Geoscience research center. The group undertakes innovative research that contributes to the understanding and improved management of land and water resources with particular reference to the impact of human activity.
Morphologi G3-ID, Particle shape, Particle size, Tech Talk »
Establishing bio-equivalence (BE) for topical dermatological drug products has been up for discussion for many years between pharmaceutical development community and the regulatory agency. Despite great advances in addressing the issues related to topical bioequivalence, many challenges remain and the lack of harmonized guidance documents tend to exacerbate the challenge.
The FDA’s Guidance for Industry document entitled “Topical Dermatological Drug Product NDAs and ANDAs —In Vivo Bioavailability, Bioequivalence, In Vitro Release, and Associated Studies” suggests that establishing bio-equivalence through the various in-vivo methods might be waived if the inactive ingredients in …
Morphologi G3-ID, Raman spectroscopy, Tech Talk »
Viva la “sameness” – Ensuring Generic Drug Equivalence
Generic drugs make up about 80% of drugs used by US consumers and the percentage of generic drugs used elsewhere around the world is rapidly growing as healthcare costs rise and generic drugs look more and more attractive. But the challenge for generic drug developers has always been ensuring equivalence to the innovator’s original drug.
Recent reports suggest that there is a $20 million quality evaluation and testing program, involving a dozen academic centers, which is being overseen by the FDA. This program is …