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Zetasizer

The world’s most widely used system for nanoparticle, colloid and protein size, zeta potential and molecular weight measurements.

Epsilon, Meet the Experts, Zetasizer »

[19 Apr 2018 | ]

Protect your company against a PR nightmare
In the last two years, companies in Asia have been fined for disposing of used industrial waste tainted with chemicals and heavy metals into the waters. In Vietnam, fish carcasses washed up on the beaches of Hà Tĩnh, many fishermen lost their livelihoods and needless to mention about water safety. While these companies have received fines, it is fair to say that waste management affects the public and ecosystem.
Malvern Panalytical supports companies with analytical solutions which ensure socially responsible disposal of used industrial water. Here …

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Customer experience, Dynamic Light Scattering, Malvern Panalytical Events, Meet the Experts, Nanoparticle Tracking Analysis, Nanosight, Particle concentration, Zeta potential, Zetasizer »

[5 Apr 2018 | ]

Malvern Panalytical Webinars

This month, we are running several webinars covering different techniques and our specialists will show you some typical examples of applications.
Here is the list of what’s coming up in April. You can register for free to all our webinars and you will automatically receive the On Demand version if you can’t finally attend the live event directly in your inbox!
19th – X-ray characterization of catalysts
Natalia Dadivanyan will present a variety of X-ray techniques for a structural characterization of catalysts on the example of automotive three-way catalysts at ambient and …

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Dynamic Light Scattering, Malvern Panalytical Events, Meet the Experts, Zeta potential, Zetasizer »

[15 Mar 2018 | ]

Dynamic Light Scattering (DLS), sometimes referred to as Photon Correlation Spectroscopy or Quasi-Elastic Light Scattering, is a technique classically used for measuring the size of particles typically in the sub-micron region, dispersed in a liquid. The sensitivity of some modern systems is such that it can also now be used to measure the size of macromolecules in solution.
In this new webinar, I summarise how the technique works, what its size and concentration limits are and discuss its advantages and disadvantages.
This webinar was well-attended and I received several questions, I thought …

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Electrophoretic light scattering, Tech Talk, Zeta potential, Zetasizer »

[6 Mar 2018 | ]

Will the zeta potential of my vesicles vary in different buffers?
 

The short answer is: Yes, it will. In select cases, the value of the measured zeta potential may remain close to the same. However, that is the exception rather than the rule. This is no different for vesicles than for other nanoparticles, biomolecules, polyelectrolytes, etc.
How does zeta change with salt concentration?
The zeta potential of a colloidal particle in solution is a description of the overall effective net charge of the particle under the sample system conditions. Thus the effective net …

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Aeris, ASD, Claisse, Epsilon, Malvern Panalytical Events, Meet the Experts, Morphologi, OMNISEC, Zetasizer »

[20 Feb 2018 | ]

This year will be the 19th Pittcon in a row that I have attended (there should be an award for that, right?). Actually, Malvern Panalytical did receive an award from Pittcon 11 years ago for our then 50th anniversary of attending the conference.  If you still have not made it to this annual gathering of the latest in laboratory equipment, educational courses and technical presentations galore, here are some reasons to consider heading to Orlando on February 26 (or Philadelphia in 2019):
1 – You can see the latest in analytical …

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Dynamic Light Scattering, Gel permeation chromatography, Kinexus, Laser Diffraction, Malvern Panalytical Events, Meet the Experts, Molecular weight, Nanoparticle Tracking Analysis, Nanosight, OMNISEC, Particle concentration, Particle size, Rheology, Rheometry, Tech Talk, Viscotek, Zeta potential, Zetasizer »

[30 Jan 2018 | ]

We will be attending Pittcon 2018 in Orlando, Florida Feb 26th – Mar 1st and once again we are pleased to feature a number of our recognized characterization experts who will be presenting a variety of short courses throughout the week.
Time is running out, so don’t miss out on the early bird deadline for discounted admission which ends on February 5th.
Below is a listing of our available short course offerings.
We look forward to seeing you in Orlando at one of our short courses and our Booths #2118 & #2119.
Monday, February 26th
Fundamentals of Particle …

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Dynamic Light Scattering, Electrophoretic light scattering, Inside Malvern Panalytical, Zeta potential, Zetasizer »

[21 Dec 2017 | ]

On the 20th December 1977 (40 years ago) the Royal Radar and Signals Establishment (RRSE) and Malvern Instruments received the coveted MacRobert Award for the development of the Malvern Correlator.  This was fundamental to the development of Photon Correlation Spectroscopy (PCS) and the evolution of the Zetasizer product line. The MacRobert award is the UK’s longest-running and most prestigious national prize for engineering innovation. Other past winners include engineers behind innovations such as the Pegasus jet engine, catalytic converters, the roof of the Millennium Dome and intelligent prosthetic limbs.
The concept …

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Customer experience, Zetasizer »

[14 Dec 2017 | ]

… and receiving a Zetasizer
 
In North America, this time of the year is the busiest period for shipping companies like DHL, Federal Express or the US Postal Service. Malvern Panalytical does not rest either, in fact, our systems are part of the global shipping growth in this busy season. As a global company certified in ISO 14001 we are conscious of our role and take measures to minimize the use of resources. One of these efforts resulted in the design of a new reusable shipping box for the Zetasizer. An …

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Dynamic Light Scattering, Kinexus, Laser Diffraction, Mastersizer, Nanoparticle Tracking Analysis, Nanosight, Rheometry, Size Exclusion Chromatography, Tech Talk, X-Ray Diffraction (XRD), Zetasizer »

[5 Dec 2017 | ]

It was my great pleasure to present as part of the Worcestershire Innovation Network at their WINN Wednesday event on the 22nd of November, showcasing the best in innovation across Worcestershire.
This included a local company which makes artificial kneecaps and hips, an insight into the building of genomics studies of patients with rare diseases and cancers, an update on the appeal to get a state-of-the-art surgical robot for removal of prostate tumors (reducing discomfort, scarring and hospital stay post-operation). Jess Antley, head of WINN, also gave an update on a new shared space/collaboration …

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Differential Scanning Calorimetry, Dynamic Light Scattering, MicroCal, Molecular size, Molecular structure, Particle size, Protein Aggregation, Tech Talk, Zetasizer »

[16 Nov 2017 | ]

Measuring aggregation temperature using the Zetasizer

In dynamic light scattering (DLS), the hydrodynamic size and size distribution of particles in solution can be obtained.  It may be of interest to examine this measurement as a function of time and temperature, or as a ‘trend’, as it is called in the Malvern Zetasizer software.  For biological protein samples, this temperature trend is particularly interesting: although at low temperatures a protein may be stable and show repeatable size (and scattering intensity) measurements, typically at some elevated temperature (Tagg), protein molecules will show a tendency …

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Dynamic Light Scattering, Molecular size, Molecular weight, Static Light Scattering, Zetasizer »

[2 Nov 2017 | ]

Molecular weight measurements with the Zetasizer software?
First a few words of caution: molecular weight or Mw measurements in general are not easy, require time, good sample preparation skills as well as patience. If you are new to the Malvern Zetasizer it might be best to familiarize yourself first with the rapid, user-friendly, and quite forgiving technique of dynamic light scattering (DLS). {{If you are experienced and want to skip to a Brainshark narrated screen recording of the steps, best viewed in Chrome, go ahead to https://www.brainshark.com/malvern/sls-with-zetasizer }}.
OK, with that out …

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Dynamic Light Scattering, Particle size, Tech Talk, Zetasizer »

[26 Sep 2017 | ]

Is there a maximum viscosity for DLS measurements?
 
The Malvern Zetasizer can determine particle size by dynamic light scattering (DLS). In this technique, the intensity fluctuations are analyzed to find the corresponding diffusion coefficient that led to the fluctuations. The translational diffusion coefficient Dt of a particle is inversely related to its size and the viscosity of the dispersant (or more accurately the hydrodynamic radius rH and viscosity η).

This relationship can be used to predict detectability limits of the technique in general, and this is how we explore the idea of …

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Archimedes, Binding affinity and Kd, Chemical identification, Differential Scanning Calorimetry, Dynamic Light Scattering, Gel permeation chromatography, Image Analysis, Label-free analysis, MicroCal, Microcalorimetry, Morphologi, Nanoparticle Tracking Analysis, Nanosight, Particle concentration, Particle shape, Particle size, Protein Aggregation, Raman spectroscopy, Resonant mass measurement, Rheology, Size Exclusion Chromatography, Taylor Dispersion Analysis, Tech Talk, Viscosizer TD, Viscotek, Zetasizer »

[21 Sep 2017 | ]

I know this sounds like the beginning of a bad joke, but in this case, it was actually the beginning of the 2017 Colorado Protein Stability Conference, held in July at Beaver Run Resort in Breckenridge, Colorado. In attendance was a range of scientists and researchers from all over the world, with one common subject in mind: Protein Stability.

One of the highlights of this conference was the pre-conference workshop. This was a free workshop for all attendees of the conference, which was sponsored by Malvern Panalytical. The workshop included a range …

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Deutsch, Insitec, Kinexus, Malvern Panalytical Events, Mastersizer, Morphologi, Nanosight, Zetasizer »

[14 Sep 2017 | ]

 

Read this blog in English
Die POWTECH ist weltweit die unangefochtene Nummer eins für Pulver-, Granulat- und Schüttguttechnologien. Sie spiegelt den aktuellen Stand der mechanischen Verfahrenstechnik und Analytik wider – und gibt damit einen einzigartigen Überblick für eine Vielzahl an Branchen. Seien Sie unser Gast und entdecken Sie auf der Leitmesse POWTECH 2017 vom 26.-28. September in Nürnberg am Malvern Panalytical Stand 1-314 alles rund um die Analytik von Pulvern, Schüttgut, Nanopartikeln und Dispersionen: Halten Sie bei uns einen Moment inne und erleben Sie gezielte Infos für Ihre Materialanalyse!
Freikarte:
Fordern Sie Ihre …

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Insitec, Kinexus, Malvern Panalytical Events, Mastersizer, Morphologi, Nanosight, Zetasizer »

[14 Sep 2017 | ]

Diesen Eintrag auf Deutsch lesen
POWTECH is the undisputed number one meeting for powder, granule and bulk solids technologies, worldwide. It provides a showcase for cutting edge technologies and instrumentation relevant to a huge range of industries: from glass, building materials and paper, to pharmaceuticals, chemicals, and food.
Be our guest from 26-28 September in Nuremberg, Germany! Come and chat to the experts from Malvern Panalytical in Hall 1, at Stand 314.
Request your free admission ticket for Powtech 2017…..

…..and when the lights go down on the exhibition, head over to our Exclusive After-Hours Malvern Panalytical Powtech Party!  
Join …

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Electrophoretic light scattering, Tech Talk, Zeta potential, Zetasizer »

[5 Sep 2017 | ]

Zetasizer: What is the zeta potential deviation?
 
The Malvern Zetasizer software report for zeta potential shows a parameter that is called Zeta deviation. This parameter is shown directly below the mean Zeta potential.

The mean zeta potential is derived from the fast field reversal (FFR) phase analysis light scattering (PALS) technique.
The fast field reversal provides a single number from the analysis. This single number is the mean zeta potential. The slow field reversal [also known as SFR] can be used to determine the zeta distribution, a distribution of different charge values from …

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Customer experience, Dynamic Light Scattering, Particle size, Zeta potential, Zetasizer »

[22 Aug 2017 | ]

Zetasizer: 21CFR? Electronic Record/Electronic Signature? Test Schedule?
 

The Malvern Zetasizer is an extremely versatile measurement system. By far the most systems are used in academic and industry research laboratories, for example in fundamental research, drug discovery, or formulation optimization. However, a significant number of installations are in operation in “controlled” environments, such as for quality control in pharmaceutical companies. Here documentation and compliance with good manufacturing standards GMP is critically important, and a specific version of the operating software exist that locks down standard operating procedures (SOP) with limited ability (based …

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Dynamic Light Scattering, Electrophoretic light scattering, Laser Diffraction, Particle size, Zeta potential, Zetasizer »

[3 Aug 2017 | ]

Intralipid-Lipid emulsions

Lipid emulsions are administered intravenously for a variety of purposes:

To help feed patients with temporary difficulty in ingesting food orally
For better transport of lipophilic drugs (fat-friendly active ingredient (API) which is not soluble in water)
For controlled release of drugs (size related to uptake and retention)
To decreasing adverse reactions to drugs
To improve targeting of drugs
In emerging gene therapies for cellular and gene delivery, and personalized medicine

Control and understanding of colloidal properties – such as droplet size and zeta potential – enable the design and optimization of appropriately stable emulsions. The …

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Electrophoretic light scattering, Meet the Experts, Protein Mobility, Zeta potential, Zetasizer »

[27 Jul 2017 | ]

Nanomaterial isoelectric points IEPs
 
In a recent webinar presented by Ana Morfesis titled “Characterizing the zeta potential & Isoelectric Point of Nanomaterials” we got such a good turnout that we were not able to address the numerous questions asked during the event.
Thank you for the participation!
Since there was such strong interest, we have provided the following list of questions and answers to benefit all who are interested.  We have also provided a table of common metal oxide IEPs, as shown to the left.
 
 
For those who were not able to attend the live event, the session was recorded and is …

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Differential Scanning Calorimetry, Dynamic Light Scattering, Meet the Experts, MicroCal, Molecular size, Molecular weight, OMNISEC, Particle concentration, Protein Aggregation, Size Exclusion Chromatography, Taylor Dispersion Analysis, Zetasizer »

[18 Jul 2017 | ]

Monoclonal Antibodies – or mAbs for short

Since many of these mAbs require refrigeration we had used dynamic light scattering (with a Zetasizer) to show the formation of aggregates after freeze-thaw cycles (for details see application note “Effect of storage conditions on Immunoglobulin“). These could be seen both in the increased polydispersity index (PDI) and the appearance of a large-size aggregate peak in the intensity size distribution as shown to the right. The area under the peak gives an indication of the presence of the large aggregates but is not suited for …

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