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Zetasizer

The world’s most widely used system for nanoparticle, colloid and protein size, zeta potential and molecular weight measurements.

Customer experience, Electrophoretic light scattering, Meet the Experts, Zeta potential, Zetasizer »

[5 Sep 2018 | ]

How can we obtain the applied field strength?
When performing electrophoretic light scattering (ELS) measurements, the sample is exposed to an externally applied electric field, and we observe the extra movement that the particles undergo as a result of the applied field with the changes in the phase difference between the un-scattered reference laser beam and the scattering from the particles. The electrophoretic mobility µ is the particle velocity v divided by the electric field strength E, where the field strength is the applied voltage over the distance between the electrodes [typically …

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Customer experience, Dynamic Light Scattering, Malvern Panalytical Events, Meet the Experts, Nanoparticle Tracking Analysis, Nanosight, Particle concentration, Zeta potential, Zetasizer »

[30 Aug 2018 | ]

Malvern Panalytical Webinars

Here is the list of the upcoming webinars in the coming weeks. You can register for free to all our webinars and you will automatically receive the On Demand version if you can’t finally attend the live event directly in your inbox!
September
 
6th – Quality by Design: Principles for pharmaceutical method development
Steve Ward-Smith will outline what QbD is, how it works within pharmaceutical development, and will provide some examples of the ‘fishbone’ diagrams which show the factors that should be considered when developing methods for laser diffraction and dynamic light scattering.
11th – Adaptive Correlation: …

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Dynamic Light Scattering, Electrophoretic light scattering, Malvern Panalytical Events, Particle size, Zetasizer »

[9 Aug 2018 | ]

Launching the latest Zetasizer in Mexico!
 
June was a special month at our Mexico City office. We held a specific launch party organized for the latest addition to our Zetasizer family of instruments – the Zetasizer Pro and the Zetasizer Ultra. One of the groundbreaking novelties in the new system is adaptive correlation, a new method to perform dynamic light scattering (DLS) measurements, where rapid correlation functions are classified as being steady state or transient. Steady-state data sets describe particles that are consistently part of the measurement volume and hence characteristic of …

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Dynamic Light Scattering, Malvern Panalytical Events, Molecular size, Nanoparticle Tracking Analysis, Nanosight, Particle concentration, Zetasizer »

[7 Aug 2018 | ]

Workshop of the LOEWE Center for Translational Medicine and Pharmacology
20th September 2018
Campus Riedberg BIOLOGICUM, Lecture hall 1, -1.202
 
As market interest and investment in nanotechnology surges and the requirements for novel formulation strategies continues to grow, the industry is under pressure to provide a detailed characterization of subvisible particle species and their interactions with biological systems.
Formulation development and manufacture of biopharmaceuticals and nanomaterials are lengthy and complex processes with very specific analytical challenges. We know that in order to successfully deliver such therapies to market it is vital to reduce risk as …

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Dynamic Light Scattering, Molecular size, Particle concentration, Particle size, Tech Talk, Zeta potential, Zetasizer »

[2 Aug 2018 | ]

 
Thanks to all who attended the launch webinar for Malvern Panalytical’s new Zetasizer systems, and special thanks to Mike Kaszuba for presenting a clear and interesting overview of the two instruments – we hope you all enjoyed it and found it interesting.

The launch of the Zetasizer Pro and Zetasizer Ultra received a great response and naturally, due to the innovations included in the new systems, lots of questions were sent to us both during and after the webinar. We’ve taken the opportunity to answer the most frequently-asked questions here, in …

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Corporate, Dynamic Light Scattering, Zeta potential, Zetasizer »

[17 Jul 2018 | ]

Severn Trent and Malvern Panalytical share award for the development of an online Zetasizer for fully automated coagulation control
Great news for the fans of zeta potential in water treatment! Zetasizer WT, the first commercial on-line zeta potential analyzer has been awarded a first place by the UK water industry in the category of “Most innovative use of existing technology”. The project titled “Online Zetasizer for fully automated coagulation control” is a collaboration between Severn Trent Water and Malvern Panalytical to enable a fully automatic control of coagulant dosing in a …

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Dynamic Light Scattering, Tech Talk, Zeta potential, Zetasizer »

[10 Jul 2018 | ]

Dynamic light scattering (DLS) is widely used for ensemble characterization of hydrodynamic particle size, but I have a number of frustrations with the technique.
We measure our valuable samples in low concentrations and in very small volumes, so we use expensive, low volume, glass cells, which are optically superior to disposable plastic cuvettes, but we spend far too much time cleaning them, significantly reducing the productivity of our group.
Also, our samples range from monodisperse proteins to polymeric nanoparticles to liposomes, ranging from the nano-scale into the micro-scale and we need to …

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Dynamic Light Scattering, Particle size, Tech Talk, Zeta potential, Zetasizer »

[28 Jun 2018 | ]

What causes the most headaches for a particle characterization scientist?
There are many answers to this question, but one of the most obvious is dust or contaminants! As someone who regularly uses Dynamic Light Scattering (DLS) to measure particle size, the possibility of there being dust or contaminants in my sample is one of the things I always bear in mind.
The way I prepare my sample, the way I store my sample before measurement, remembering to put the measurement cap on the cuvette, but only after I’ve cleaned it using an …

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Electrophoretic light scattering, Malvern Panalytical Events, Meet the Experts, Molecular size, Nanoparticle Tracking Analysis, Nanosight, Particle concentration, Particle size, Zeta potential, Zetasizer »

[19 Jun 2018 | ]

I presented a new webinar focusing on “A basic introduction to Electrophoretic Light Scattering (ELS)“. In this presentation, I explained the importance of Zeta potential measurements for colloidal dispersions and how it is determined using ELS.
As you certainly know, Electrophoretic Light Scattering (ELS) is a technique used to measure the electrophoretic mobility of particles or molecules in solution. This measurement is used to determine Zeta potential, which is a measure of the electrostatic or charges repulsion/attraction between particles and is a predictor of emulsion and dispersion stability. Zeta potential is …

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Dynamic Light Scattering, Meet the Experts, Zeta potential, Zetasizer »

[14 Jun 2018 | ]

Have you ever tried to explain to someone that the large peak they can see in their dynamic light scattering data, that seems to dominate the size distribution by intensity – is actually only a very tiny part of the sample…and hardly ‘there’ at all?
This has happened to me on numerous occasions, and I always try to show the volume and number size distributions, illustrating how that peak disappears. However, there is often a lingering question hanging in the air: “But if we see it, then it’s there, right?”
In the …

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Binding affinity and Kd, Differential Scanning Calorimetry, Dynamic Light Scattering, Gel permeation chromatography, Isothermal Titration Calorimetry, Label-free analysis, Malvern Panalytical Events, Meet the Experts, MicroCal, Microcalorimetry, Molecular size, OMNISEC, Protein Aggregation, Size Exclusion Chromatography, Taylor Dispersion Analysis, Viscosizer TD, Viscotek, Zetasizer »

[13 Jun 2018 | ]

The time is fast arriving for the third in our highly successful series of European MicroCal meetings! This year the meeting is organized by Malvern Panalytical alongside a Scientific Committee of expert users from academia and industry, all with the support of the ARBRE-MOBIEU network. Our venue will be the prestigious Institute of Engineering and Technology (IET), within the historical Savoy Place, perched on the north bank of the River Thames, with spectacular views across London.
The event will focus on applications, best practice, advanced data analysis and all the latest developments in both isothermal …

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Dynamic Light Scattering, Electrophoretic light scattering, Particle size, Tech Talk, Zeta potential, Zetasizer »

[31 May 2018 | ]

How good can a gold standard be?
 
When performing dynamic light scattering (DLS) measurements, we sometimes encounter especially nice data. An interesting issue to consider is the level of data quality one can expect to achieve, under ideal circumstances, when all other interferences are minimized. This is especially relevant at the smaller nanoscale where fewer standards are available, and to those who have less practical experience with sizing colloidal nanoparticles by DLS. How monodisperse can a good sample be? What are achievable polydispersity index (PDI) values to aspire to?
What is the …

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Corporate, Dynamic Light Scattering, Electrophoretic light scattering, Molecular size, Molecular weight, Particle concentration, Particle size, Zeta potential, Zetasizer »

[23 May 2018 | ]

Where is the Zetasizer used?
 
For around two decades, the Zetasizer range has been the de facto standard for performing dynamic light scattering (DLS) measurements on a wide range of particles and materials.
Today’s launch of the Zetasizer Pro and Zetasizer Ultra – which took place earlier today on May 23rd, 2018 – provides a good reason to summarize the key application areas for light scattering technology: both dynamic and electrophoretic! Where are these Zetasizers used? Where can we find them, in the real world?
Below is a list of key application focus areas:

Bioscience and biopharmaceuticals: …

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Customer experience, Dynamic Light Scattering, Molecular size, Particle size, Tech Talk, Zetasizer »

[15 May 2018 | ]

The peaks in your distribution are out of order?
We recently received an email about the order of peaks in the Zetasizer software:
For data evaluation, is it possible to rearrange the NNLS results by order of particle size populations?”
How the peaks are shown (by area)

Size measurement results are typically viewed in the Intensity PSD (M) tab. This is part of the standard Size and Summary workspaces.  When a record contains more than one peak, these results will be tabulated in the table above the intensity size distribution. The default ordering in …

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Epsilon, Meet the Experts, Zetasizer »

[19 Apr 2018 | ]

Check your manufacturing waste before disposing
In the last two years, companies in Asia have been fined for disposing of used industrial waste tainted with chemicals and heavy metals into the waters. In Vietnam, fish carcasses washed up on the beaches of Hà Tĩnh, many fishermen lost their livelihoods and needless to mention about water safety. While these companies have received fines, it is fair to say that waste management affects the public and ecosystem.
Malvern Panalytical supports companies with analytical solutions which ensure socially responsible disposal of used industrial water. Here are …

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Dynamic Light Scattering, Malvern Panalytical Events, Meet the Experts, Zeta potential, Zetasizer »

[15 Mar 2018 | ]

Dynamic Light Scattering (DLS), sometimes referred to as Photon Correlation Spectroscopy or Quasi-Elastic Light Scattering, is a technique classically used for measuring the size of particles typically in the sub-micron region, dispersed in a liquid. The sensitivity of some modern systems is such that it can also now be used to measure the size of macromolecules in solution.
In this new webinar, I summarise how the technique works, what its size and concentration limits are and discuss its advantages and disadvantages.
This webinar was well-attended and I received several questions, I thought …

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Electrophoretic light scattering, Tech Talk, Zeta potential, Zetasizer »

[6 Mar 2018 | ]

Will the zeta potential of my vesicles vary in different buffers?
 

The short answer is: Yes, it will. In select cases, the value of the measured zeta potential may remain close to the same. However, that is the exception rather than the rule. This is no different for vesicles than for other nanoparticles, biomolecules, polyelectrolytes, etc.
How does zeta change with salt concentration?
The zeta potential of a colloidal particle in solution is a description of the overall effective net charge of the particle under the sample system conditions. Thus the effective net …

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Aeris, ASD, Claisse, Epsilon, Malvern Panalytical Events, Meet the Experts, Morphologi, OMNISEC, Zetasizer »

[20 Feb 2018 | ]

This year will be the 19th Pittcon in a row that I have attended (there should be an award for that, right?). Actually, Malvern Panalytical did receive an award from Pittcon 11 years ago for our then 50th anniversary of attending the conference.  If you still have not made it to this annual gathering of the latest in laboratory equipment, educational courses and technical presentations galore, here are some reasons to consider heading to Orlando on February 26 (or Philadelphia in 2019):
1 – You can see the latest in analytical …

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Dynamic Light Scattering, Gel permeation chromatography, Kinexus, Laser Diffraction, Malvern Panalytical Events, Meet the Experts, Molecular weight, Nanoparticle Tracking Analysis, Nanosight, OMNISEC, Particle concentration, Particle size, Rheology, Rheometry, Tech Talk, Viscotek, Zeta potential, Zetasizer »

[30 Jan 2018 | ]

We will be attending Pittcon 2018 in Orlando, Florida Feb 26th – Mar 1st and once again we are pleased to feature a number of our recognized characterization experts who will be presenting a variety of short courses throughout the week.
Time is running out, so don’t miss out on the early bird deadline for discounted admission which ends on February 5th.
Below is a listing of our available short course offerings.
We look forward to seeing you in Orlando at one of our short courses and our Booths #2118 & #2119.
Monday, February 26th
Fundamentals of Particle …

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Dynamic Light Scattering, Electrophoretic light scattering, Inside Malvern Panalytical, Zeta potential, Zetasizer »

[21 Dec 2017 | ]

On the 20th December 1977 (40 years ago) the Royal Radar and Signals Establishment (RRSE) and Malvern Instruments received the coveted MacRobert Award for the development of the Malvern Correlator.  This was fundamental to the development of Photon Correlation Spectroscopy (PCS) and the evolution of the Zetasizer product line. The MacRobert award is the UK’s longest-running and most prestigious national prize for engineering innovation. Other past winners include engineers behind innovations such as the Pegasus jet engine, catalytic converters, the roof of the Millennium Dome and intelligent prosthetic limbs.
The concept …

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