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Nanoparticle Tracking Analysis, Nanosight, Particle concentration, Tech Talk »

[23 Nov 2017 | ]

Results of a multi-round interlaboratory comparison (ILC) of NanoSight instruments were recently published1, setting a benchmark for repeatability and reproducibility for the Nanoparticle Tracking Analysis (NTA) technique. The limits of measurement were shown to extend beyond the 30 nm –600 nm range (with all NanoSight models), with percentage coefficients of variation (% CV), calculated as sub 5% for monodisperse samples. The process further highlighted how much variability or error might be introduced if inappropriate instrument settings or analytical procedures are used.
As a relatively new technique, there remained questions about the …

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Epsilon, Meet the Experts, X-Ray Fluorescence (XRF) »

[21 Nov 2017 | ]

Whether it is for mineral exploration or mining waste analysis, there is a time lapse between bringing samples back to the laboratory, analysis and making decisions in the field.
Increasingly, governments are focusing on protecting the environment. Companies can be charged with hefty environmental fines. Minimise your company’s risk through quick analysis of undesirable environmental waste elements.
Imagine if you could have the flexibility to react quickly by analyzing samples while traveling between mine sites. Here’s a tip on how to set up a mobile lab in your car with the Epsilon …

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Differential Scanning Calorimetry, Dynamic Light Scattering, MicroCal, Molecular size, Molecular structure, Particle size, Protein Aggregation, Tech Talk, Zetasizer »

[16 Nov 2017 | ]

Measuring aggregation temperature using the Zetasizer

In dynamic light scattering (DLS), the hydrodynamic size and size distribution of particles in solution can be obtained.  It may be of interest to examine this measurement as a function of time and temperature, or as a ‘trend’, as it is called in the Malvern Zetasizer software.  For biological protein samples, this temperature trend is particularly interesting: although at low temperatures a protein may be stable and show repeatable size (and scattering intensity) measurements, typically at some elevated temperature (Tagg), protein molecules will show a tendency …

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Français, Insitec, Laser Diffraction, Malvern Panalytical Events, Meet the Experts, Particle size »

[15 Nov 2017 | ]

Le Salon des technologies des solides et liquides en vrac

Nous serons présents sur le Salon Vrac Tech du 28 au 30 novembre 2017 – Hall C – Stand A19.
Vous pourrez découvrir nos granulomètres laser pour contrôler vos procédés de fabrication de poudres jusqu’à 1 mm et des sondes pour mesurer des granulés en ligne jusqu’à 6 mm. En effet, le contrôle des procédés de broyage intéresse et concerne de plus en plus d’usines de l’industrie alimentaire.
Rejoignez nous et demandez votre badge!
Informations pratiques :
Parc des Expositions du Mans
1, Avenue du Parc des Expositions
72100 Le Mans
Coordonnées …

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ASD, Ground truthing, Near-InfraRed spectroscopy (NIR), Remote sensing, Tech Talk »

[14 Nov 2017 | ]

This November, the ASD webinar focuses on hyperspectral imaging, near infrared spectroscopy (NIRS), and multivariate calibration models (i.e. chemometrics), featuring ASD’s FieldSpec® 4 Hi-Res NG Spectroradiometer.

In this webinar, you will learn:

How the combination of hyperspectral imaging, near-infrared spectroscopy (NIRS), and multivariate calibration algorithms (i.e. chemometrics), enables quantitative mapping of properties of the Earth’s surface
The data that ground-based reflectance measurements of materials can provide for remote sensing applications
How to apply quantitative chemometric calibrations to hyperspectral image data
Examples of successful applications

November’s ASD webinar speaker is Dr. Brian Curtiss; Brian is one of …

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Aeris, Customer experience, X-Ray Diffraction (XRD) »

[9 Nov 2017 | ]

I recently had the pleasure to visit a new Aeris customer in Orlando, FL – Louis C. Herring Laboratory. This service lab has been in business for over 60 years, specializing in the analysis of kidney stones, also known as urinary calculi. What I found amazing about this site is that their Aeris actually replaced a Philips Analytical PW1840 system, our first generation benchtop XRD produced in the early 1980s. Their PW1840 ran for three decades, amassing over 41,000 hours of operating time and requiring little to no service through …

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Dynamic Light Scattering, Molecular size, Molecular weight, Static Light Scattering, Zetasizer »

[2 Nov 2017 | ]

Molecular weight measurements with the Zetasizer software?
First a few words of caution: molecular weight or Mw measurements in general are not easy, require time, good sample preparation skills as well as patience. If you are new to the Malvern Zetasizer it might be best to familiarize yourself first with the rapid, user-friendly, and quite forgiving technique of dynamic light scattering (DLS).
OK, with that out of the way, the software can handle static light scattering with the relatively simple concentration series method. All that’s required is

a scattering standard (which is usually …

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Insitec, Laser Diffraction, Malvern Panalytical Events, Particle size »

[19 Oct 2017 | ]

Downstream in-line monitoring for better processes and products
Every second is critical towards rectifying a plant upset or ensuring efficient plant management. What if you could incorporate in-line analysis for your dry and liquid products?
Companies that introduced in-line particle size analysis at the milling stage noticed significantly less over-milling. Hence seeing as much as a 2% increase in plant throughput. In-line elemental analysis allows petrochemical companies to closely monitor Fe, Ni, V which destroy expensive catalysts.
Why incorporate in-line analysis?

Real-time monitoring of your batches
Make immediate corrections to poor batches
Prevent wastage
Improve your manufacturing …

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Binding affinity and Kd, Isothermal Titration Calorimetry, Meet the Experts, MicroCal, Microcalorimetry »

[12 Oct 2017 | ]

Isothermal Titration Calorimetry
Molecular recognition is key in all biological processes and cellular responses. It is critical to characterize the structural and thermodynamic forces behind the recognition and specificity of macromolecular interactions in order to understand the molecular events in a cell. Several biophysical techniques (including fluorescence, circular dichroism, Fourier transform infrared spectroscopy, mass spectroscopy, surface plasmon resonance, and microscale thermophoresis) are used to characterize non-covalent molecular interactions.
Isothermal titration calorimetry (ITC) has become a popular and versatile bioanalytical method for the direct measurement of binding affinity between interacting molecules.  ITC instruments were …

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Laser Diffraction, Malvern Panalytical Events, Mastersizer »

[10 Oct 2017 | ]

Consumers increasingly demand more from their electronic devices. For example longer lasting and safe batteries, high resolution LCD, smaller and smarter PCBs etc. Malvern Panalytical has multiple analytical solutions for batteries, LCDs, wafers, printed circuit boards and more. This is so you have high performance yet safe and compliant electronic products.
Read more about our solutions below:

Prevent battery plates from wearing out easily by monitoring the particle size distribution and packing density with the Mastersizer laser diffraction technique.
Batteries having issues with recharging? The Gailpix3D XRD detector uses X-ray diffraction and computed tomography to …

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Insitec, Laser Diffraction, Mastersizer, Meet the Experts, Particle size »

[5 Oct 2017 | ]

The heavy cost of mining and minerals manufacturing
The importance of minerals as a production resource applies to many facets of our daily lives. For instance, the quality of concrete determines the smoothness of a road surface and the sturdiness of a building. However, with the ever-growing demands for quality cement, many have spurred manufacturing processes leading to hefty costs. Such costs incurred comes from wastage when having to reproduce cement because it does not meet the quality standard.
Based on a mechanical and civil engineering study, 6-15% of construction costs …

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Chemical identification, Image Analysis, Meet the Experts, Morphologi G3-ID, Particle shape, Raman spectroscopy »

[29 Sep 2017 | ]

I have just come back from presenting my talk ‘Application of Morphologically-Directed Raman Spectroscopy in deformulation and in vitro bioequivalence studies’ at the pharma focus session of Powtech 2017.
The talk indicated how there are still many drug products that have come of patent but do not yet have generic equivalents available and how there is a drive from the regulatory bodies to make health care more accessible and so they are producing many guidance documents to help address this.
I gave an overview of a proposed workflow for developing generic drug …

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Dynamic Light Scattering, Particle size, Tech Talk, Zetasizer »

[26 Sep 2017 | ]

Is there a maximum viscosity for DLS measurements?
 
The Malvern Zetasizer can determine particle size by dynamic light scattering (DLS). In this technique, the intensity fluctuations are analyzed to find the corresponding diffusion coefficient that led to the fluctuations. The translational diffusion coefficient Dt of a particle is inversely related to its size and the viscosity of the dispersant (or more accurately the hydrodynamic radius rH and viscosity η).

This relationship can be used to predict detectability limits of the technique in general, and this is how we explore the idea of …

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Archimedes, Binding affinity and Kd, Chemical identification, Differential Scanning Calorimetry, Dynamic Light Scattering, Gel permeation chromatography, Image Analysis, Label-free analysis, MicroCal, Microcalorimetry, Morphologi G3-ID, Nanoparticle Tracking Analysis, Nanosight, Particle concentration, Particle shape, Particle size, Protein Aggregation, Raman spectroscopy, Resonant mass measurement, Rheology, Size Exclusion Chromatography, Taylor Dispersion Analysis, Tech Talk, Viscosizer TD, Viscotek, Zetasizer »

[21 Sep 2017 | ]

I know this sounds like the beginning of a bad joke, but in this case, it was actually the beginning of the 2017 Colorado Protein Stability Conference, held in July at Beaver Run Resort in Breckenridge, Colorado. In attendance was a range of scientists and researchers from all over the world, with one common subject in mind: Protein Stability.

One of the highlights of this conference was the pre-conference workshop. This was a free workshop for all attendees of the conference, which was sponsored by Malvern Panalytical. The workshop included a range …

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Binding affinity and Kd, Isothermal Titration Calorimetry, MicroCal, Tech Talk »

[12 Sep 2017 | ]

Binding Affinity
 
Understanding binding affinity is key to appreciation of the intermolecular interactions driving biological processes, structural biology, and structure-function relationships. It is also measured as part of the drug discovery process to help design drugs that bind their targets selectively and specifically.
We recently launched a new short video showcasing the MicroCal PEAQ-ITC and how it is an essential piece to any biological interaction analysis toolkit for measuring Binding affinity and stoichiometry.

The MicroCal PEAQ-ITC offers key benefits over other ITC systems including:
PEAQ-Expert: New easy-to-use software to guide your way includes built-in …

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Chemical identification, Image Analysis, Meet the Experts, Morphologi G3, Morphologi G3-ID, Particle shape »

[7 Sep 2017 | ]

Standing at just under 3800 m tall with its distinctive symmetrical cone-shaped peak, the majestic Mount Fuji, or Fujisan (富士山) as it is known locally, is one of the most iconic symbols of Japan.
Therefore, it seemed only appropriate that whilst on secondment in Malvern’s Tokyo application lab, I should attempt to reach the summit of this famous volcano and, in something of a cliché, watch the sunrise from the highest peak in the Land of the Rising Sun.
There is only a short window each year in which one is permitted …

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Electrophoretic light scattering, Tech Talk, Zeta potential, Zetasizer »

[5 Sep 2017 | ]

Zetasizer: What is the zeta potential deviation?
 
The Malvern Zetasizer software report for zeta potential shows a parameter that is called Zeta deviation. This parameter is shown directly below the mean Zeta potential.

The mean zeta potential is derived from the fast field reversal (FFR) phase analysis light scattering (PALS) technique.
The fast field reversal provides a single number from the analysis. This single number is the mean zeta potential. The slow field reversal [also known as SFR] can be used to determine the zeta distribution, a distribution of different charge values from …

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Morphologi G3-ID, Particle shape, Raman spectroscopy, Tech Talk »

[31 Aug 2017 | ]

GEN covers the role of MDRS in reducing the need for clinical bioequivalence endpoint studies
 
Morphologically-Directed Raman Spectroscopy (MDRS) combines the capabilities of automated imaging with Raman spectroscopy in a single platform, creating a powerful analytical tool that spans multiple industries. It exhibits particular value in both innovator and generic pharmaceutical development, as detailed particle characterization enables a thorough understanding of individual materials and how they impact the final product – as demonstrated by a recent Malvern Panalytical article, featured on the GEN website.
 
Raman spectroscopy and MDRS enable determination of the …

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Meet the Experts, Nanoparticle Tracking Analysis, Nanosight, Particle concentration »

[24 Aug 2017 | ]

I recently presented a webinar titled “Basic Principles of Nanoparticle Tracking Analysis: Size, Concentration and Speciation with Single-Particle Resolution”. We got such a good turnout that we were not able to address the numerous questions asked during the event.
Thank you for the participation!

Since there was such strong interest, we have provided the following list of questions and answers to benefit all who are interested.
Q: In DLS also we can get lognormal number distribution. How is the NTA number distribution different?
NTA yields a number weighted distribution because it is a particle …

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Customer experience, Dynamic Light Scattering, Particle size, Zeta potential, Zetasizer »

[22 Aug 2017 | ]

Zetasizer: 21CFR? Electronic Record/Electronic Signature? Test Schedule?
 

The Malvern Zetasizer is an extremely versatile measurement system. By far the most systems are used in academic and industry research laboratories, for example in fundamental research, drug discovery, or formulation optimization. However, a significant number of installations are in operation in “controlled” environments, such as for quality control in pharmaceutical companies. Here documentation and compliance with good manufacturing standards GMP is critically important, and a specific version of the operating software exist that locks down standard operating procedures (SOP) with limited ability (based …

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