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Gel permeation chromatography

Gel Permeation Chromatography (GPC) is an analytical technique that separates dissolved macromolecules by size based on their elution from columns filled with a porous gel.

From novel polymers to polymer formulations and additives, in applications from paints and coatings to foods and pharmaceuticals, Malvern offers a range of GPC systems or individual GPC detectors including SEC-MALS to suit your application needs.

Binding affinity and Kd, Differential Scanning Calorimetry, Dynamic Light Scattering, Gel permeation chromatography, Isothermal Titration Calorimetry, Label-free analysis, Malvern Panalytical Events, Meet the Experts, MicroCal, Microcalorimetry, Molecular size, OMNISEC, Protein Aggregation, Size Exclusion Chromatography, Taylor Dispersion Analysis, Viscosizer TD, Viscotek, Zetasizer »

[13 Jun 2018 | ]

The time is fast arriving for the third in our highly successful series of European MicroCal meetings! This year the meeting is organized by Malvern Panalytical alongside a Scientific Committee of expert users from academia and industry, all with the support of the ARBRE-MOBIEU network. Our venue will be the prestigious Institute of Engineering and Technology (IET), within the historical Savoy Place, perched on the north bank of the River Thames, with spectacular views across London.
The event will focus on applications, best practice, advanced data analysis and all the latest developments in both isothermal …

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Français, Gel permeation chromatography, Malvern Panalytical Events, Meet the Experts, Molecular size, Molecular structure, Molecular weight, OMNISEC »

[9 May 2018 | ]

Atelier dans notre agence de Lyon mardi 12 juin

Journée sur la chromatographie d’exclusion de taille pour les protéines (ou de perméation de gel pour les polymères) dans notre agence de Lyon.
Vous seront présentés différents systèmes de détection UV, réfractomètre, diffusion de lumière, viscosité intrinsèque, MALS, connectables sur tous les types de colonnes, ainsi que sur des systèmes UHPLC.
Nous vous accueillerons à partir de 8h30 et les présentations commenceront à 9h00. Après le déjeuner (offert), se tiendront des sessions d’essais clients jusqu’à 16h30, date de la fin de la journée.
La participation à …

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Corporate, Gel permeation chromatography, Malvern Panalytical Events, OMNISEC »

[1 May 2018 | ]

Malvern Panalytical recently announced a co-marketing agreement with Waters Corporation for the use of our advanced GPC/SEC (Gel Permeation Chromatography / Size Exclusion Chromatography) detectors with their UPLC system, the APC.  Our advanced detector module OMNISEC REVEAL includes a refractive index (RI), a UV/Vis photodiode array, light scattering for measuring molecular weight, and a viscometer for measuring molecular structure.  The Waters ACQUITY APC uses columns with advanced, small particles to generate high-resolution separations in short run times.
In the past these systems haven’t been able to work together because the resolution is lost as …

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Dynamic Light Scattering, Gel permeation chromatography, Kinexus, Laser Diffraction, Malvern Panalytical Events, Meet the Experts, Molecular weight, Nanoparticle Tracking Analysis, Nanosight, OMNISEC, Particle concentration, Particle size, Rheology, Rheometry, Tech Talk, Viscotek, Zeta potential, Zetasizer »

[30 Jan 2018 | ]

We will be attending Pittcon 2018 in Orlando, Florida Feb 26th – Mar 1st and once again we are pleased to feature a number of our recognized characterization experts who will be presenting a variety of short courses throughout the week.
Time is running out, so don’t miss out on the early bird deadline for discounted admission which ends on February 5th.
Below is a listing of our available short course offerings.
We look forward to seeing you in Orlando at one of our short courses and our Booths #2118 & #2119.
Monday, February 26th
Fundamentals of Particle …

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Gel permeation chromatography, Molecular weight, OMNISEC »

[23 Jan 2018 | ]

Examples of Polystyrene, Polyvinylchloride and Polycarbonate measurements
When Waters Corp. released the ACQUITY Advanced Polymer Chromatography (APCTM) system for polymer analysis it brought the unsurpassed resolution of UPLC separations to the polymer market. The system allows resolution between polymer fractions not previously seen with the added advantage of low sample use, low solvent use, and significantly quicker analysis. This was, of course, a fantastic step forward but retained the need for column calibration to give relative molecular weight distributions. How accurate these values depend on the chemical and structural similarities between …

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Archimedes, Binding affinity and Kd, Chemical identification, Differential Scanning Calorimetry, Dynamic Light Scattering, Gel permeation chromatography, Image Analysis, Label-free analysis, MicroCal, Microcalorimetry, Morphologi, Nanoparticle Tracking Analysis, Nanosight, Particle concentration, Particle shape, Particle size, Protein Aggregation, Raman spectroscopy, Resonant mass measurement, Rheology, Size Exclusion Chromatography, Taylor Dispersion Analysis, Tech Talk, Viscosizer TD, Viscotek, Zetasizer »

[21 Sep 2017 | ]

I know this sounds like the beginning of a bad joke, but in this case, it was actually the beginning of the 2017 Colorado Protein Stability Conference, held in July at Beaver Run Resort in Breckenridge, Colorado. In attendance was a range of scientists and researchers from all over the world, with one common subject in mind: Protein Stability.

One of the highlights of this conference was the pre-conference workshop. This was a free workshop for all attendees of the conference, which was sponsored by Malvern Panalytical. The workshop included a range …

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Archimedes, Customer experience, Differential Scanning Calorimetry, Gel permeation chromatography, Image Analysis, MicroCal, Morphologi, Nanoparticle Tracking Analysis, Nanosight, Particle size, Protein Aggregation, Raman spectroscopy, Resonant mass measurement, Viscotek »

[1 Jun 2017 | ]

Our key driver at Malvern Instruments is to create technologies that make a difference or solve a problem, and working hand-in-hand with our customers enables us to make sure that’s exactly what’s happening, out in the field.  We place a high value on our collaborations and partnerships with customers from a wide range of industries and organizations across the globe and love to see how our systems are being used in real-world scenarios.  This gives us vital feedback on what we’re doing well, and also any tweaks we need to make in order to optimize …

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Gel permeation chromatography, Molecular weight, OMNISEC, Size Exclusion Chromatography, Tech Talk »

[23 Feb 2017 | ]

Recently, I’ve presented a new webinar focusing on the protein characterization using the OMNISEC, the highest quality Gel Permeation Chromatography (GPC) / Size Exclusion Chromatography (SEC) system for the measurement of absolute molecular weight, molecular size, intrinsic viscosity, branching and other parameters. Thank you to all participants for your interest and attention during the webinar.
In this webinar, I highlighted the key features and benefits of the OMNISEC system. How to run samples and analyze data and how to access repeatability of multiple sample measurements.

As usual, after the live section of …

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Binding affinity and Kd, Differential Scanning Calorimetry, Dynamic Light Scattering, Français, Gel permeation chromatography, Image Analysis, Isothermal Titration Calorimetry, Laser Diffraction, Meet the Experts, Molecular size, Nanoparticle Tracking Analysis, Particle concentration, Particle size, Rheology, Rheometry, Size Exclusion Chromatography, Static Light Scattering, Zeta potential »

[21 Feb 2017 | ]

Afin de vous apporter un support concret pour utiliser votre système de façon optimale, finaliser vos bonnes pratiques de laboratoire et répondre à vos besoins spécifiques, Malvern organise des formations sur site ou en sessions dans nos 3 agences françaises (Orsay, Lyon et Toulouse).
Voici les dates de toutes les sessions programmées pour 2017 :
CARACTERISATION DES PARTICULES PAR DIFFRACTION LASER
Objectifs : Perfectionner les méthodes de caractérisation des particules en voie sèche et liquide, définir les bonnes pratiques de laboratoire et s’adapter aux besoins spécifiques de chaque installation. Comprendre le principe physique …

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Gel permeation chromatography, Malvern Panalytical Events, OMNISEC, Size Exclusion Chromatography »

[7 Feb 2017 | ]

Last year we asked you to tell us about your most interesting or challenging Gel Permeation Chromatography (GPC) / Size Exclusion Chromatography (SEC) sample and why it presented such a challenge. For instance, if you’ve made two polymers which should be different but you can’t tell apart; or have polymers that are so small you don’t have the sensitivity to measure accurately.
The top 3 submissions that presented the biggest challenge to our new OMNISEC advanced GPC/SEC system would be awarded with a full sample analysis along with a prize of …

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Dynamic Light Scattering, Gel permeation chromatography, Malvern Panalytical Events, Meet the Experts, Nanoparticle Tracking Analysis, Size Exclusion Chromatography, Zeta potential »

[26 Jan 2017 | ]

We will be attending Pittcon 2017 in Chicago, Illinois March 5th – 9th and once again we are pleased to feature a number of our recognized characterization experts who will be presenting a variety of short courses throughout the week.
Time is running out, so don’t miss out on the early bird deadline for discounted admission which ends on February 18th.
Below is a listing of our available short course offerings.
We look forward to seeing you in Chicago at one of our short courses and our Booth #2416.
Sunday, March 5, 2017 – 8:30 AM
Light Scattering …

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Gel permeation chromatography, Malvern Panalytical Events, Molecular size, Molecular weight, OMNISEC, Size Exclusion Chromatography, Viscotek »

[8 Dec 2016 | ]

Version Française
The French symposium of the French Group of Studies and Applications of Polymers (GFP) is the major French congress of polymers.
The 45th edition took place recently in Marseille under the bold architecture of the Villa Méditerranée, designed by Stefano Boeri, a committed actor of the Italian political and cultural scene.

During this conference, we presented the benefits of Viscotek SEC MALS 20.
The SEC-MALS 20 multi-angle light scattering detector  can be used on all GPC / SEC systems and especially Malvern’s latest OMNISEC range. The 20 signals of the SEC-MALS detectors connected …

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Français, Gel permeation chromatography, Malvern Panalytical Events, Molecular size, Molecular weight, OMNISEC, Size Exclusion Chromatography, Viscotek »

[8 Dec 2016 | ]

English version
Le colloque national du Groupe Français d’études et d’applications des Polymères (GFP) est le congrès français majeur des polymères.
La 45ème édition s’est déroulée récemment à Marseille sous l’architecture audacieuse de la Villa Méditerranée, conçue par Stefano Boeri, acteur engagé de la scène politique et culturelle italienne.

Durant ce congrès, nous avons présenté les avantages du Viscotek SEC MALS 20.
Le détecteur de diffusion de lumière multi-angle Viscotek SEC-MALS 20 peut être utilisé sur tous les systèmes de GPC/SEC et notamment sur le dernier OMNISEC de la gamme Malvern. Les signaux des 20 détecteurs du SEC-MALS …

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Gel permeation chromatography, Meet the Experts, OMNISEC »

[15 Nov 2016 | ]

Ever wondered what it would be like to use Malvern’s OMNISEC GPC system?
Now you can find out, from the comfort of your own desk! Malvern’s OMNISEC Demo at your Desk webinar provides an in-depth look at the OMNISEC hardware and a thorough demonstration of the user-friendly OMNISEC software.
In this webinar, I highlight key features of OMNISEC Resolve, which is the chromatography unit, including the low-volume degasser, low-pulsation pump with back seal washing, autosampler with temperature control from 4-60°C that can make injection volumes down to 5 µL, and a …

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Gel permeation chromatography, Meet the Experts, OMNISEC »

[29 Sep 2016 | ]

Gel Permeation Chromatography school – Become an expert
Have you ever found yourself with a bunch of GPC data, and didn’t know how to use it?  You’re in luck!
Come on down to Malvern’s Houston, Texas facility on October 19-20, 2016 for a two-day course designed to deliver comprehensive knowledge of Malvern’s GPC/SEC technologies and make you an expert!  We will cover the theory behind the advanced detection options of Malvern’s GPC/SEC instruments, as well as providing a thorough presentation of the OmniSEC software.
You’ll leave the course with an understanding of all …

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Gel permeation chromatography, Malvern Panalytical Events, Meet the Experts, Molecular weight, OMNISEC, Size Exclusion Chromatography, Tech Talk, Viscotek »

[13 Sep 2016 | ]

Together with Sysmex, our distributor in Benelux, we are proud to be Gold Sponsors of the International Symposium on GPC/SEC and Related Techniques, taking place from 26-29th September in Amsterdam.
One of our technical experts, John Stenson, is looking forward to presenting some exciting new data in his talk “Combining multi-detector GPC measurements with ultra-high pressure GPC separations” at 3:30 pm on Wednesday 28th September, and says:
“This presentation will discuss the issues related to dispersion and how these can be minimized. We will then show the first high quality data from a combined multi-detector/ UPLC™ …

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Gel permeation chromatography, »

[30 Aug 2016 | ]

GPC explained in 30 minutes
Macromolecules, including both natural and synthetic polymers and proteins, have become ingrained in our everyday life.
Everything from the plastic in toys, the pipes in your house, to the components in your food and medicine are comprised of macromolecules.  As such, complete and accurate characterization of these materials is critical in order to maintain the integrity and performance of their end products, and also to help develop more novel and functional polymeric components. Gel permeation chromatography, or GPC, is the analytical technique commonly used to provide this essential …

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Gel permeation chromatography, Protein Aggregation, Tech Talk, Viscotek, Zetasizer »

[15 Sep 2015 | ]

How can a quartz cuvette be properly cleaned?
The Zetasizer has a flow cell [ZEN0023] used in conjunction with either the titrator, the NanoSampler, or as a chromatography or field flow fractionation detector. A similar flow cell [ZMV1008] is also in use with the Zetasizer microV when used as a molecular weight detector in conjunction with the OmniSEC software. Advanced cuvettes may also be used in UV-Vis, fluorescence & circular dichroism spectrophotometers, MALLS as well as goniometer systems and other specialized optical detection. If the signal from the quartz cell is …

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Gel permeation chromatography, Malvern Panalytical Events, Meet the Experts, OMNISEC, Size Exclusion Chromatography, Viscotek »

[1 Sep 2015 | ]

Malvern is offering a two-day course designed to deliver comprehensive knowledge of Malvern’s Viscotek GPC/SEC technologies. The course will be held in Malvern’s Houston, Texas facility from October 21-22, 2015 and will cover the theory behind the advanced detection options of Malvern’s GPC/SEC instruments, as well as a thorough presentation of the OmniSEC software. This ensures that users will leave the course with an understanding of all of the hardware and the software that their sample interacts with, and how to extract the most information from their sample.
Topics covered in …

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Gel permeation chromatography, Molecular size, Molecular structure, Molecular weight, OMNISEC, Size Exclusion Chromatography, Tech Talk »

[14 Jul 2015 | ]

Multi-detector SEC – 10 reasons why protein scientists need one
In a previous post I listed the top ten reasons why a polymer characterization scientist might want to upgrade to multi-detector Gel Permeation Chromatography/Size Exclusion Chromatography, but there are similar points to be made as to why a protein characterization scientist might do the same.  We often focus on the benefits of our own systems but sometimes we may miss the benefits of the basic technique.
If you are a protein characterization scientist and you find yourself thinking, “My UV detector works …

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