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Image Analysis

Automated imaging is a high resolution direct technique for characterizing particles. Individual particle images are captured from dispersed samples and analyzed to determine their particle size, particle shape and other physical properties.

ASD, Ground truthing, Image Analysis, Meet the Experts, Near-InfraRed spectroscopy (NIR), Remote sensing »

[30 Nov 2017 | ]

The ASD FieldSpec 4 Hi-Res NG provides enhanced spectral resolution to support accurate calibration and image classification analysis.
Higher resolution hyperspectral sensors yield greater precision for remote sensing classification applications, producing more information from every pixel generated in an image than ever before. In order to take advantage of the full potential of these sensors, measurements from ground-based instrumentation need to meet or exceed the sensor’s spectral resolution. In the absence of this resolution equality, data are interpolated during post-processing; as a result, vital spectral information can be smoothed and lost.
The enhanced spectral resolution …

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Chemical identification, Image Analysis, Meet the Experts, Morphologi G3-ID, Particle shape, Raman spectroscopy »

[29 Sep 2017 | ]

I have just come back from presenting my talk ‘Application of Morphologically-Directed Raman Spectroscopy in deformulation and in vitro bioequivalence studies’ at the pharma focus session of Powtech 2017.
The talk indicated how there are still many drug products that have come of patent but do not yet have generic equivalents available and how there is a drive from the regulatory bodies to make health care more accessible and so they are producing many guidance documents to help address this.
I gave an overview of a proposed workflow for developing generic drug …

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Archimedes, Binding affinity and Kd, Chemical identification, Differential Scanning Calorimetry, Dynamic Light Scattering, Gel permeation chromatography, Image Analysis, Label-free analysis, MicroCal, Microcalorimetry, Morphologi G3-ID, Nanoparticle Tracking Analysis, Nanosight, Particle concentration, Particle shape, Particle size, Protein Aggregation, Raman spectroscopy, Resonant mass measurement, Rheology, Size Exclusion Chromatography, Taylor Dispersion Analysis, Tech Talk, Viscosizer TD, Viscotek, Zetasizer »

[21 Sep 2017 | ]

I know this sounds like the beginning of a bad joke, but in this case, it was actually the beginning of the 2017 Colorado Protein Stability Conference, held in July at Beaver Run Resort in Breckenridge, Colorado. In attendance was a range of scientists and researchers from all over the world, with one common subject in mind: Protein Stability.

One of the highlights of this conference was the pre-conference workshop. This was a free workshop for all attendees of the conference, which was sponsored by Malvern Panalytical. The workshop included a range …

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Chemical identification, Image Analysis, Meet the Experts, Morphologi G3, Morphologi G3-ID, Particle shape »

[7 Sep 2017 | ]

Standing at just under 3800 m tall with its distinctive symmetrical cone-shaped peak, the majestic Mount Fuji, or Fujisan (富士山) as it is known locally, is one of the most iconic symbols of Japan.
Therefore, it seemed only appropriate that whilst on secondment in Malvern’s Tokyo application lab, I should attempt to reach the summit of this famous volcano and, in something of a cliché, watch the sunrise from the highest peak in the Land of the Rising Sun.
There is only a short window each year in which one is permitted …

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Chemical identification, Image Analysis, Morphologi G3-ID »

[25 Jul 2017 | ]

Why is it that structures built in Roman times have resisted the elements for thousands of years when more modern structures have suffered?
This was a question posed in a recent BBC news story ‘Scientists explain ancient Rome’s long-lasting concrete’ that caught my eye since we have pondered the question here at Malvern before as you can see in this application note “Component Characterization of Cements” where the Morphologi G3-ID was used to study and compare the composition of different cements.

How is the concrete made?
Ancient structures are built using concrete made from …

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Archimedes, Customer experience, Differential Scanning Calorimetry, Gel permeation chromatography, Image Analysis, MicroCal, Morphologi G3-ID, Nanoparticle Tracking Analysis, Nanosight, Particle size, Protein Aggregation, Raman spectroscopy, Resonant mass measurement, Viscotek »

[1 Jun 2017 | ]

Our key driver at Malvern Instruments is to create technologies that make a difference or solve a problem, and working hand-in-hand with our customers enables us to make sure that’s exactly what’s happening, out in the field.  We place a high value on our collaborations and partnerships with customers from a wide range of industries and organizations across the globe and love to see how our systems are being used in real-world scenarios.  This gives us vital feedback on what we’re doing well, and also any tweaks we need to make in order to optimize …

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Image Analysis, Laser Diffraction, Mastersizer, Morphologi G3, Tech Talk »

[13 Apr 2017 | ]

The prevalence of chocolate eggs and chocolate bunnies in the supermarkets here in the UK can only signal one thing: Easter is upon us.  With the emergence of daffodils, buds appearing on trees, lambs frolicking in the fields and warmth seeping back into the northern hemisphere, the cold winter months are over.  Of course, it is not just in the western world that the arrival of spring, new life and new beginnings are celebrated.
In Japan, a country I had the pleasure of living in for a year and a half …

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Binding affinity and Kd, Differential Scanning Calorimetry, Dynamic Light Scattering, Français, Gel permeation chromatography, Image Analysis, Isothermal Titration Calorimetry, Laser Diffraction, Meet the Experts, Molecular size, Nanoparticle Tracking Analysis, Particle concentration, Particle size, Rheology, Rheometry, Size Exclusion Chromatography, Static Light Scattering, Zeta potential »

[21 Feb 2017 | ]

Afin de vous apporter un support concret pour utiliser votre système de façon optimale, finaliser vos bonnes pratiques de laboratoire et répondre à vos besoins spécifiques, Malvern organise des formations sur site ou en sessions dans nos 3 agences françaises (Orsay, Lyon et Toulouse).
Voici les dates de toutes les sessions programmées pour 2017 :
CARACTERISATION DES PARTICULES PAR DIFFRACTION LASER
Objectifs : Perfectionner les méthodes de caractérisation des particules en voie sèche et liquide, définir les bonnes pratiques de laboratoire et s’adapter aux besoins spécifiques de chaque installation. Comprendre le principe physique …

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Chemical identification, Image Analysis, Laser Diffraction, Malvern Panalytical Events, Mastersizer, Morphologi G3-ID, Particle shape, Particle size, Raman spectroscopy »

[29 Jun 2016 | ]

Over the past week I’ve had a lot of fun working with Malvern’s team in China to deliver a series of seminars designed to help researchers engaged in pharmaceutical product development. These meetings focused on how Malvern’s material characterization systems can help those developing and manufacturing oral solid dose formulations. During the seminar series, we had the privilege of meeting with well over 200 customers, providing us with the chance to learn about the challenges they are facing in product development, as they seek to select APIs and excipients which …

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Chemical identification, Image Analysis, Laser Diffraction, Mastersizer, Meet the Experts, Morphologi G3-ID, Particle shape, Particle size, Raman spectroscopy, Tech Talk »

[20 Jun 2016 | ]

Component-specific Particle Size
Follow that particle!

I’ve always thought it would be great to be the innocent driver in a movie chase scene who has to respond to the hero’s demand to ‘Follow that car’ as they try to keep tabs on the villain. I always imaged that this would unlock the silent racing driver within me, giving me the excuse to forget about speed limits and drive at the limits of my car’s performance. I’d also get the chance to practice my handbrake turns!
Although I have never been engaged in a …

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Image Analysis, Morphologi G3-ID, Particle shape, Particle size, Raman spectroscopy, Tech Talk »

[11 Aug 2015 | ]

When working with a couple of our Morphologi G3-ID cement customers I have come to realize that cement is an incredibly complex product. Working with one of our customers in the cement industry we wrote an article, published last year in International Cement Review, discussing some of the challenges facing the cement industry and how the Morphologi G3-ID can help face these challenges.
Cements can contain a large number of components including any number of additives to adapt the cement behavior, the size and shape of any of these components can …

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Image Analysis, Laser Diffraction, Malvern Panalytical Events, Mastersizer, Particle shape, Particle size, Tech Talk »

[28 Oct 2014 | ]

This month we revealed the Hydro Sight and the Hydro SV accessories with a live lab ‘party’ celebrating 3 years since the launch of the Mastersizer 3000. The two new accessories have been designed to help our Mastersizer 3000 users achieve smarter particle sizing.
Since becoming Product Manager for the Imaging team here at Malvern, launching the Hydro Sight was a first for me so it has been a very exciting time. Not only because it is my first launch but also because the accessory itself actually brings Laser Diffraction and …

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Image Analysis, Morphologi G3, Sysmex FPIA-3000, Tech Talk »

[8 Apr 2014 | ]

After the last Imaging Masterclass on good experimental practice I thought I would share my top tips for sample preparation, based on my own experience. You can view the recording of the webinar here.
Get to know your sample!
The first thing I would advise anyone to do is to look at their sample. Take a dry powder – by tumbling a pot of sample you can assess how cohesive or how sticky a sample is. Small particles, smaller than 10 microns or so can be very cohesive due to high surface energy …

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Image Analysis, Morphologi G3, Particle shape »

[11 Mar 2014 | ]

During February we held the first session in our popular Imaging Masterclass series, “Understanding the application of automated analytical imaging for particle size and particle shape analysis.”  The class introduced the basic concepts of image analysis, discussing the parameters that can be measured and how this information relates to real world problems. You can view a recording of the webinar on our website.
We had lots of questions at the end of the session, which is always the sign of a great class.  We weren’t able to get through all of …

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Image Analysis, Morphologi G3, Particle shape, Particle size »

[26 Jun 2013 | ]

As a product technical specialist I get to see many applications and customers. Something that has regularly come up is the problem of measuring fibers by image analysis.
Caliper based length and width measurements of fibers do not always give an accurate representation of the fiber, particularly if the fiber is curved or branched.
Now we have introduced four new fiber parameters for the Morphologi G3. The parameters give a measurement of the total length of a fiber including branches and also an average width over the total fiber length. These measurements …

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Image Analysis, Laser Diffraction, Mastersizer, Morphologi G3, Particle shape, Particle size, Tech Talk »

[11 Jun 2013 | ]

Some of my colleagues might say that I have a brain like a sieve : I’m not sure, but I don’t think they mean I classify everything into discrete particle size fractions 🙂 !
Sieving is still a very widely used technique in many industries where particle size is important, however laser diffraction is now being used routinely by many of these industries to gain much more detailed and robust particle size measurements.
If you’re thinking of switching from sieving to laser diffraction for your particle size measurements, Malvern have put together …

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Dynamic Light Scattering, Electrophoretic light scattering, Image Analysis, Insitec, Laser Diffraction, Mastersizer, Morphologi G3, Parsum, Particle shape, Particle size, Rheology, Spatial Filter Velocimetry, Spraytec, Sysmex FPIA-3000, Tech Talk, Zeta potential, Zetasizer »

[15 May 2013 | ]

Particle Characterization Explained
There is a wide range of commercially available particle characterization techniques that can be used to measure particulate samples. Each has its relative strengths and limitations and there is no universally applicable technique for all samples and all situations.
Which particle characterization techniques do I need?
A number of criteria must be considered when deciding which particle characterization techniques you need:
• which particle properties are important to me?
• what particle size range do I want to work over?
• are my samples polydisperse i.e. do I need a wide dynamic range?
• …

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Image Analysis, Morphologi G3, Particle shape, Particle size, Sysmex FPIA-3000, Tech Talk »

[2 May 2013 | ]

For many particle characterization applications, a particle size distribution provides adequate information about the sample. However, for some applications particle shape can provide more appropriate or complementary information. There are three main categories where this is relevant:
Single particles or agglomerates?
Many particle sizing methods require complete dispersion of any agglomerates in the sample in order to make an appropriate measurement. Being able to view individual images in the dispersion and analyze them in terms of their outline shape allows the user to determine whether or not agglomerates are present and the …

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Image Analysis, Morphologi G3, Particle shape, Particle size, Sysmex FPIA-3000, Tech Talk »

[25 Apr 2013 | ]

Many customers are not as familiar with automated imaging as a particle characterization technique. Here are three good reasons why you might want to consider automated imaging in addition to your more established techniques such as laser diffraction or microscopy.
Better understanding of particle properties
Automated imaging can provide data on particle size, shape, transparency and chemical identity in one measurement. In contrast to ensemble-based techniques such as laser diffraction, each individual particle in the sample is measured one-by-one, providing high resolution detailed information. This is often used to complement data from …

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Corporate, Image Analysis, Meet the Experts »

[23 Oct 2012 | ]
Sampling nuts

I was watching QI recently and host Stephen Fry asked “Why do Brazil Nuts always rise to the top in a packet of mixed nuts?”
(For those who don’t know QI is a BBC quiz show, the quiz is about facts that are not widely known, or widely accepted facts that are in fact not true. Contestants are rewarded for answers that are Quite Interesting, thus the name QI.)
The answer to this question, according to QI, was ‘no-one knows’. Regular contestant Alan Davies received a bonus for this answer, a rare occurrence for Alan, but I …

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