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Laser Diffraction

Laser diffraction is a widely used particle sizing technique for materials ranging from hundreds of nanometers up to several millimeters in size.

Dynamic Light Scattering, Electrophoretic light scattering, Laser Diffraction, Particle size, Zeta potential, Zetasizer »

[3 Aug 2017 | ]

Intralipid-Lipid emulsions

Lipid emulsions are administered intravenously for a variety of purposes:

To help feed patients with temporary difficulty in ingesting food orally
For better transport of lipophilic drugs (fat-friendly active ingredient (API) which is not soluble in water)
For controlled release of drugs (size related to uptake and retention)
To decreasing adverse reactions to drugs
To improve targeting of drugs
In emerging gene therapies for cellular and gene delivery, and personalized medicine

Control and understanding of colloidal properties – such as droplet size and zeta potential – enable the design and optimization of appropriately stable emulsions. The …

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Laser Diffraction, Mastersizer, Particle size, Tech Talk »

[1 Aug 2017 | ]

Just when I thought I’d seen everything that could contaminate the background, a user sent me this picture! The Musca Domestica (common housefly) was attracted by certain aromatics used in testing and seems to have entered the measurement cell through an empty Hydro EV over a weekend. Unfortunately, it became wedged within the measurement cell and did not survive the experience.

The most important message from the Mastersizer training courses I give is to make sure you have a good background before you start. Laser diffraction is a background subtracted technique: …

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Laser Diffraction, Mastersizer, Meet the Experts, Particle size, Tech Talk »

[13 Jun 2017 | ]

I recently presented a webinar exploring the practical aspects of sieving method – the advantages and disadvantages.  I compared the method to other techniques such as laser diffraction indicating the increased wealth of information that can be obtained with these more modern instrumental techniques and the common pitfalls and assumptions of the screening technique.
More than 800 of you registered for the webinar and I received a large numbers of interesting questions which I have been working steadily through. I thought it would be a good idea to share the questions and answers via the blog, so here they …

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Français, Insitec, Laser Diffraction, Malvern Events, Meet the Experts, Particle shape, Particle size »

[2 May 2017 | ]

Malvern organise des formations en collaboration avec la société SDTech Micro et SDTech Nano, son partenaire technique depuis 7 ans.

SDTech Micro, situé à Alès, est spécialisé dans l’analyse et le traitement à façon des poudres fines et ultrafines.
La semaine derniere, SDtech organisait les journees techniques avec Glatt et Malvern. Des présentations théoriques s’enchainerent avec des ateliers sur un granulateur Glatt en mode “granulation” le premier jour puis en mode “enrobage” le deuxième jour.

 

En parallèle une démonstration de broyage sur un microniseur à jet d’air contrôlé entièrement par un granulomètre laser …

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Image Analysis, Laser Diffraction, Mastersizer, Morphologi G3, Tech Talk »

[13 Apr 2017 | ]

The prevalence of chocolate eggs and chocolate bunnies in the supermarkets here in the UK can only signal one thing: Easter is upon us.  With the emergence of daffodils, buds appearing on trees, lambs frolicking in the fields and warmth seeping back into the northern hemisphere, the cold winter months are over.  Of course, it is not just in the western world that the arrival of spring, new life and new beginnings are celebrated.
In Japan, a country I had the pleasure of living in for a year and a half …

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Français, Insitec, Laser Diffraction, Meet the Experts, Parsum, Particle size, Spatial Filter Velocimetry »

[23 Mar 2017 | ]

“Lit d’air fluidisé : Granulation, Enrobage et Encapsulation”

Malvern, leader en caractérisation des particules, SDTech Micro, expert des poudres fines, et son partenaire technique Glatt, leader mondial en lit d’air fluidisé, organisent deux journées techniques pour aborder les enjeux et les nouveautés technologiques des procédés de granulation, d’enrobage et d’encapsulation en lit d’air fluidisé. Rappels théoriques et ateliers pratiques sont au programme.
THEMATIQUES :
25 avril :

Présentation de SDTech et de Glatt
Lit d’air fluidisé, techniques et technologies
De la poudre aux grains, caractérisation
1er atelier : Granulation en lit d’air fluidisé

26 avril :

Sécurité des poudres …

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Binding affinity and Kd, Differential Scanning Calorimetry, Dynamic Light Scattering, Français, Gel permeation chromatography, Image Analysis, Isothermal Titration Calorimetry, Laser Diffraction, Meet the Experts, Molecular size, Nanoparticle Tracking Analysis, Particle concentration, Particle size, Rheological and Viscosity, Rheometry - Rotational, Size Exclusion Chromatography, Static Light Scattering, Zeta potential »

[21 Feb 2017 | ]

Afin de vous apporter un support concret pour utiliser votre système de façon optimale, finaliser vos bonnes pratiques de laboratoire et répondre à vos besoins spécifiques, Malvern organise des formations sur site ou en sessions dans nos 3 agences françaises (Orsay, Lyon et Toulouse).
Voici les dates de toutes les sessions programmées pour 2017 :
CARACTERISATION DES PARTICULES PAR DIFFRACTION LASER
Objectifs : Perfectionner les méthodes de caractérisation des particules en voie sèche et liquide, définir les bonnes pratiques de laboratoire et s’adapter aux besoins spécifiques de chaque installation. Comprendre le principe physique …

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Dynamic Light Scattering, Français, Laser Diffraction, Malvern Events, Meet the Experts, Nanosight, Particle size, Static Light Scattering, Zetasizer »

[23 Nov 2016 | ]

Les 20èmes rencontres organisées à Rennes auront lieu du 28 au 30 novembre avec la collaboration l’Institut des Sciences Chimiques de Rennes et la plateforme ScanMat. La directrice de cette plateforme, Maryline Guilloux-Viry, nous fera l’honneur d’accueillir les participants et de présenter les moyens et compétences disponibles au sein de la fédération des 5 plateformes constituant ScanMat (Microscopies électroniques, Analyses structurales et élémentaire, Synthèse et mise en forme, Spectroscopies et Microspectroscopies optiques).
Les nanoparticules seront au cœur de ces rencontres avec une évocation des nouvelles réglementations de REACH qui seront en vigueur …

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Dynamic Light Scattering, Laser Diffraction, Mastersizer, Particle size, Tech Talk, Zetasizer »

[25 Aug 2016 | ]

Size distributions are a description of the fact that not every component in the sample has the same size.  There is a range of sizes present, as mathematically described by a distribution.
There are different ways to represent this distribution in terms of:

Intensity – How much light comes from the different components?
Volume or mass – How much volume is present in the different components?
Number – How many particles are present in the different components?

This often causes confusion, and the intensity volume number issue is one of the most popular blogs.
Intuitively most …

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Chemical identification, Image Analysis, Laser Diffraction, Malvern Events, Mastersizer, Morphologi G3-ID, Particle shape, Particle size, Raman spectroscopy »

[29 Jun 2016 | ]

Over the past week I’ve had a lot of fun working with Malvern’s team in China to deliver a series of seminars designed to help researchers engaged in pharmaceutical product development. These meetings focused on how Malvern’s material characterization systems can help those developing and manufacturing oral solid dose formulations. During the seminar series, we had the privilege of meeting with well over 200 customers, providing us with the chance to learn about the challenges they are facing in product development, as they seek to select APIs and excipients which …

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Dynamic Light Scattering, Laser Diffraction, Mastersizer, Particle size, Tech Talk, Zetasizer »

[23 Jun 2016 | ]

Analysis of Mushroom Farming – Mushrooms meet Malvern
Malvern Instruments has made its name in particle sizing: the flagships Mastersizer and  Zetasizer have become the de facto global standard tools for particle sizing from nanometers to millimeters.  The breadth of applications for these technologies is simply astounding and we are constantly seeing new uses in diverse areas. As just one example, the video below shows use of a Mastersizer 2000 in a Lingzhi mushroom research facility, where state-of-the-art cultivation techniques are developed and improved.

The Lingzhi mushroom is also known as the reishi mushroom and …

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Chemical identification, Image Analysis, Laser Diffraction, Mastersizer, Meet the Experts, Morphologi G3-ID, Particle shape, Particle size, Raman spectroscopy, Tech Talk »

[20 Jun 2016 | ]

Component-specific Particle Size
Follow that particle!

I’ve always thought it would be great to be the innocent driver in a movie chase scene who has to respond to the hero’s demand to ‘Follow that car’ as they try to keep tabs on the villain. I always imaged that this would unlock the silent racing driver within me, giving me the excuse to forget about speed limits and drive at the limits of my car’s performance. I’d also get the chance to practice my handbrake turns!
Although I have never been engaged in a …

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Laser Diffraction, Mastersizer, Particle size »

[8 Sep 2015 | ]

Particle size of coffee and Premium coffee!
How the particle size of coffee can affect the taste and strength of coffee
As a Malvern product manager, I am privileged to get the chance to travel to different locations around the world in order to meet Malvern’s users and engage with our sales teams. As a result, I get to stay in a lot of hotels.
Now, as with other travellers, I have developed my own list of requirements for assessing whether a given hotel is worth visiting again. I don’t know what you …

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Laser Diffraction, Mastersizer, Particle size »

[13 Aug 2015 | ]

One of the questions I am regularly asked by my Mastersizer customers is how much sample do I need to measure?
I get the feeling people are hoping for a simple answer, such as 1g, 10ml etc. Unfortunately, the science of sampling is not so straightforward…
An expert in sampling, Francis F Pitard, says “a sample is equitable when it is reproducible and accurate enough to satisfy both the supplier and the customer”. I take this to mean the results need to be reproducible AND have RSDs for the percentiles that satisfy …

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Customer experience, Laser Diffraction, Mastersizer, Particle size, Spraytec »

[4 Aug 2015 | ]

Regular readers of this blog will know that one of the most important pieces of advice we provide with respect to setting product specifications or developing new methods is that one number is never enough. For example, a single measurement is always perfect and tells you nothing about how a method is performing – it is only by making repeat measurements that the method’s performance can be ascertained. And when it comes to setting specifications, selecting a single number from a Malvern analysis report and using it as a quality …

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Inside Malvern, Kinexus, Laser Diffraction, Mastersizer, Particle size, Rheological and Viscosity, Rheometry - Rotational »

[7 Jul 2015 | ]

My name is Thea Miksch and I recently visited Malvern Instruments for a six day work experience placement.  It was quite a big thing for me since I came from Germany to the UK for this placement. I was a little scared that I wouldn’t understand anything about the technology, but the Malvern employees were great at explaining it so even I got it!
One of the many things I learned is that there is science behind everything. I never thought of the particle size of chocolate or the viscosity of …

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Laser Diffraction, Mastersizer, Particle size, Tech Talk »

[16 Jun 2015 | ]

Batteries, and the chargers for them, are everywhere. They are available in a wide range of specifications using a variety of chemistries. The characteristics of the battery are determined by the particle size of the electrolyte powder, or slurry, and the surface roughness of the electrodes, which is determined by the particle size of its coating. By controlling the surface area, through particle size, a battery can be optimised for high capacity or high power.
The capacity of a battery is the amount of electrical charge it can deliver at the …

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Laser Diffraction, Particle size, Tech Talk »

[28 May 2015 | ]

I was stuck in traffic on the M8 travelling between Edinburgh and Glasgow when a news item really pricked my ears up. Scientists from Edinburgh University’s school of GeoSciences have been investigating better ways of measuring the extent of ash clouds following volcanic eruptions, looking at particle size.Following the Eyjafjallajokull Icelandic volcano eruption in 2010, the ash cloud drifted across the major flight paths in the North Atlantic and over Northern Europe and as a result, planes were grounded and people stranded. At first the airlines said they wouldn’t fly …

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Laser Diffraction, Mastersizer, Particle shape, Particle size, Sysmex FPIA-3000, Tech Talk »

[14 May 2015 | ]

In this series of blogs I, and some of my colleagues, would like to share some of our experience in particle sizing for industrial applications. I thought we’d do this by going through an A to Z of industrial applications and as Aardvarks are too big for our instruments, we’ll start with A for abrasives.
To be an abrasive, a material needs to be harder than the material that you want remove or polish (unless you have got a very, very long time to wait – think glacial!). The original scale …

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Kinexus, Laser Diffraction, Mastersizer, Particle size, Rheological and Viscosity, Rheometry - Rotational »

[30 Apr 2015 | ]

Nutri Ninja Pro Vs the Nutribullet
Smoothie Wars! Which blends the best?
Here at Malvern Instruments, we seem to enjoy testing the rheological properties of drinks, particularly those of the alcoholic variety! Just before Christmas John Duffy and Steve Carrington looked into the differences between traditional ales and more recently they explored the properties of Guinness. Any excuse to go down the pub…!
Therefore, it was probably about time to explore the healthier option on the drinks menu, and an ideal hangover cure – smoothies. Additionally this was a perfect opportunity to demonstrate …

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