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Nanoparticle Tracking Analysis

Nanoparticle Tracking Analysis (NTA) utilizes the properties of both light scattering and Brownian motion in order to obtain the particle size distribution of samples in liquid suspension.

Customer experience, Dynamic Light Scattering, Malvern Panalytical Events, Meet the Experts, Nanoparticle Tracking Analysis, Nanosight, Particle concentration, Zeta potential, Zetasizer »

[30 Aug 2018 | ]

Malvern Panalytical Webinars

Here is the list of the upcoming webinars in the coming weeks. You can register for free to all our webinars and you will automatically receive the On Demand version if you can’t finally attend the live event directly in your inbox!
September
 
6th – Quality by Design: Principles for pharmaceutical method development
Steve Ward-Smith will outline what QbD is, how it works within pharmaceutical development, and will provide some examples of the ‘fishbone’ diagrams which show the factors that should be considered when developing methods for laser diffraction and dynamic light scattering.
11th – Adaptive Correlation: …

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Dynamic Light Scattering, Malvern Panalytical Events, Molecular size, Nanoparticle Tracking Analysis, Nanosight, Particle concentration, Zetasizer »

[7 Aug 2018 | ]

Workshop of the LOEWE Center for Translational Medicine and Pharmacology
20th September 2018
Campus Riedberg BIOLOGICUM, Lecture hall 1, -1.202
 
As market interest and investment in nanotechnology surges and the requirements for novel formulation strategies continues to grow, the industry is under pressure to provide a detailed characterization of subvisible particle species and their interactions with biological systems.
Formulation development and manufacture of biopharmaceuticals and nanomaterials are lengthy and complex processes with very specific analytical challenges. We know that in order to successfully deliver such therapies to market it is vital to reduce risk as …

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Electrophoretic light scattering, Malvern Panalytical Events, Meet the Experts, Molecular size, Nanoparticle Tracking Analysis, Nanosight, Particle concentration, Particle size, Zeta potential, Zetasizer »

[19 Jun 2018 | ]

I presented a new webinar focusing on “A basic introduction to Electrophoretic Light Scattering (ELS)“. In this presentation, I explained the importance of Zeta potential measurements for colloidal dispersions and how it is determined using ELS.
As you certainly know, Electrophoretic Light Scattering (ELS) is a technique used to measure the electrophoretic mobility of particles or molecules in solution. This measurement is used to determine Zeta potential, which is a measure of the electrostatic or charges repulsion/attraction between particles and is a predictor of emulsion and dispersion stability. Zeta potential is …

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Malvern Panalytical Events, Nanoparticle Tracking Analysis, Nanosight, Particle concentration »

[2 May 2018 | ]

We’re on our way out to the biggest meeting of the year on extracellular vesicles, International Society of Extracellular Vesicles (ISEV) in Barcelona. We at Malvern Panalytical, together with our local partner Iesmat, can’t wait to meet you all in Palau de Congressos de Barcelona later this week! We know how much NanoSight systems are valued in exosome and microvesicle research, so would like to take the opportunity to network closely with our current and future NanoSight users and introduce the new Sample Assistant. So, whether you have a specific question …

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Meet the Experts, Nanoparticle Tracking Analysis, Nanosight, Particle concentration »

[1 Mar 2018 | ]

I am excited that the Sample Assistant autosampler for the NanoSight NS300 was recently launched as we are get increasing numbers of requests for automated NTA analyses. The full launch webinar is available showing the system in operation and the user interfaces.
Having worked with several of the beta test sites, I can see how valuable this accessory will be in the field. Many of our users are testing increasing numbers of samples, some to the point where a person is essentially full time testing samples on the NanoSight system. On one …

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Dynamic Light Scattering, Gel permeation chromatography, Kinexus, Laser Diffraction, Malvern Panalytical Events, Meet the Experts, Molecular weight, Nanoparticle Tracking Analysis, Nanosight, OMNISEC, Particle concentration, Particle size, Rheology, Rheometry, Tech Talk, Viscotek, Zeta potential, Zetasizer »

[30 Jan 2018 | ]

We will be attending Pittcon 2018 in Orlando, Florida Feb 26th – Mar 1st and once again we are pleased to feature a number of our recognized characterization experts who will be presenting a variety of short courses throughout the week.
Time is running out, so don’t miss out on the early bird deadline for discounted admission which ends on February 5th.
Below is a listing of our available short course offerings.
We look forward to seeing you in Orlando at one of our short courses and our Booths #2118 & #2119.
Monday, February 26th
Fundamentals of Particle …

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Dynamic Light Scattering, Kinexus, Laser Diffraction, Mastersizer, Nanoparticle Tracking Analysis, Nanosight, Rheometry, Size Exclusion Chromatography, Tech Talk, X-Ray Diffraction (XRD), Zetasizer »

[5 Dec 2017 | ]

It was my great pleasure to present as part of the Worcestershire Innovation Network at their WINN Wednesday event on the 22nd of November, showcasing the best in innovation across Worcestershire.
This included a local company which makes artificial kneecaps and hips, an insight into the building of genomics studies of patients with rare diseases and cancers, an update on the appeal to get a state-of-the-art surgical robot for removal of prostate tumors (reducing discomfort, scarring and hospital stay post-operation). Jess Antley, head of WINN, also gave an update on a new shared space/collaboration …

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Nanoparticle Tracking Analysis, Nanosight, Particle concentration, Tech Talk »

[23 Nov 2017 | ]

Results of a multi-round interlaboratory comparison (ILC) of NanoSight instruments were recently published1, setting a benchmark for repeatability and reproducibility for the Nanoparticle Tracking Analysis (NTA) technique. The limits of measurement were shown to extend beyond the 30 nm –600 nm range (with all NanoSight models), with percentage coefficients of variation (% CV), calculated as sub 5% for monodisperse samples. The process further highlighted how much variability or error might be introduced if inappropriate instrument settings or analytical procedures are used.
As a relatively new technique, there remained questions about the …

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Archimedes, Binding affinity and Kd, Chemical identification, Differential Scanning Calorimetry, Dynamic Light Scattering, Gel permeation chromatography, Image Analysis, Label-free analysis, MicroCal, Microcalorimetry, Morphologi, Nanoparticle Tracking Analysis, Nanosight, Particle concentration, Particle shape, Particle size, Protein Aggregation, Raman spectroscopy, Resonant mass measurement, Rheology, Size Exclusion Chromatography, Taylor Dispersion Analysis, Tech Talk, Viscosizer TD, Viscotek, Zetasizer »

[21 Sep 2017 | ]

I know this sounds like the beginning of a bad joke, but in this case, it was actually the beginning of the 2017 Colorado Protein Stability Conference, held in July at Beaver Run Resort in Breckenridge, Colorado. In attendance was a range of scientists and researchers from all over the world, with one common subject in mind: Protein Stability.

One of the highlights of this conference was the pre-conference workshop. This was a free workshop for all attendees of the conference, which was sponsored by Malvern Panalytical. The workshop included a range …

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Meet the Experts, Nanoparticle Tracking Analysis, Nanosight, Particle concentration »

[24 Aug 2017 | ]

I recently presented a webinar titled “Basic Principles of Nanoparticle Tracking Analysis: Size, Concentration and Speciation with Single-Particle Resolution”. We got such a good turnout that we were not able to address the numerous questions asked during the event.
Thank you for the participation!

Since there was such strong interest, we have provided the following list of questions and answers to benefit all who are interested.
Q: In DLS also we can get lognormal number distribution. How is the NTA number distribution different?
NTA yields a number weighted distribution because it is a particle …

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Customer experience, Nanoparticle Tracking Analysis, Nanosight, Particle concentration »

[17 Aug 2017 | ]

Being involved with the NanoSight products gives us visibility over a wide range of research areas that have a direct benefit to science and humanity. It is quite exciting to feel we are contributing to advancing science in these fields.
I was prompted to do a quick review of recent publications to see where NanoSight systems are being used after reading a recent article by Lara Aqrawi on characterizing extracellular vesicles in tears and saliva as a non-invasive diagnostic method for primary Sjögren’s syndrome (pSS) patients. Nanoparticle tracking analysis was conducted …

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Archimedes, Customer experience, Differential Scanning Calorimetry, Gel permeation chromatography, Image Analysis, MicroCal, Morphologi, Nanoparticle Tracking Analysis, Nanosight, Particle size, Protein Aggregation, Raman spectroscopy, Resonant mass measurement, Viscotek »

[1 Jun 2017 | ]

Our key driver at Malvern Instruments is to create technologies that make a difference or solve a problem, and working hand-in-hand with our customers enables us to make sure that’s exactly what’s happening, out in the field.  We place a high value on our collaborations and partnerships with customers from a wide range of industries and organizations across the globe and love to see how our systems are being used in real-world scenarios.  This gives us vital feedback on what we’re doing well, and also any tweaks we need to make in order to optimize …

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Binding affinity and Kd, Differential Scanning Calorimetry, Dynamic Light Scattering, Français, Gel permeation chromatography, Image Analysis, Isothermal Titration Calorimetry, Laser Diffraction, Meet the Experts, Molecular size, Nanoparticle Tracking Analysis, Particle concentration, Particle size, Rheology, Rheometry, Size Exclusion Chromatography, Static Light Scattering, Zeta potential »

[21 Feb 2017 | ]

Afin de vous apporter un support concret pour utiliser votre système de façon optimale, finaliser vos bonnes pratiques de laboratoire et répondre à vos besoins spécifiques, Malvern organise des formations sur site ou en sessions dans nos 3 agences françaises (Orsay, Lyon et Toulouse).
Voici les dates de toutes les sessions programmées pour 2017 :
CARACTERISATION DES PARTICULES PAR DIFFRACTION LASER
Objectifs : Perfectionner les méthodes de caractérisation des particules en voie sèche et liquide, définir les bonnes pratiques de laboratoire et s’adapter aux besoins spécifiques de chaque installation. Comprendre le principe physique …

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Dynamic Light Scattering, Gel permeation chromatography, Malvern Panalytical Events, Meet the Experts, Nanoparticle Tracking Analysis, Size Exclusion Chromatography, Zeta potential »

[26 Jan 2017 | ]

We will be attending Pittcon 2017 in Chicago, Illinois March 5th – 9th and once again we are pleased to feature a number of our recognized characterization experts who will be presenting a variety of short courses throughout the week.
Time is running out, so don’t miss out on the early bird deadline for discounted admission which ends on February 18th.
Below is a listing of our available short course offerings.
We look forward to seeing you in Chicago at one of our short courses and our Booth #2416.
Sunday, March 5, 2017 – 8:30 AM
Light Scattering …

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Customer experience, Differential Scanning Calorimetry, Dynamic Light Scattering, Français, Isothermal Titration Calorimetry, Meet the Experts, Nanoparticle Tracking Analysis, Tech Talk »

[14 Dec 2016 | ]

Journée d’information APGI/MALVERN – “Nouvelles méthodes de caractérisations des biomolécules”

Mercredi 11 janvier 2017 au CNAM
Co-organisé avec APGI et le CNAM
Avec le développement rapide de biomolécules dans les nouvelles thérapies, des techniques de caractérisation innovantes se développent en parallèle des techniques classiques (comme par exemple la chromatographie d’exclusion couplées à de la triple ou tetra détection, ou la technique NTA, très adaptée à la mesure des exosomes, des particules subvisibles et tout autre type de contaminant, etc).
C’est pourquoi l’APGI (Association de Pharmacie Galénique Industrielle) et Malvern vous invitent à une journée …

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Dynamic Light Scattering, Nanoparticle Tracking Analysis, Nanosight, Particle concentration, Particle size, Protein Aggregation, Tech Talk, Zetasizer »

[15 Sep 2016 | ]

Nanoparticle Tracking Analysis or Dynamic Light Scattering ?
After a recent joint NanoSight and Zetasizer demonstration, I received this set of questions that helps illustrate the core of the issue of these two techniques:

Since the Nanosight gives me particle concentration, it’s somewhat straightforward to calculate what % of my Nanoparticles are aggregated. Can I calculate % aggregated particles in the DLS as well?  Or does the varying amount of intensity, and the protein+nanoparticle mixture in the sample confound that calculation?

If I wanted to measure non-spherical particles (for example nanorods), which …

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Nanoparticle Tracking Analysis, Nanosight, Particle concentration, Particle size, Protein Aggregation, Tech Talk »

[26 May 2016 | ]

We recently published our application note, “Adeno-Associated Virus titer and aggregation characterization“, which discusses a new NanoSight method that allows the visualization and therefore analysis of viruses smaller than what was previously possible to measure.  This represents an exciting extension of the Nanoparticle Tracking Analysis (NTA) technique in response to market demand for tools for better characterization of small virus types.
 
Adeno-Associated Virus (AAV) is commonly used in the gene therapy field as a delivery vector. Tools to characterize both the concentration and purity or aggregation of the samples are limited because the primary virus size is …

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Isothermal Titration Calorimetry, Meet the Experts, Nanoparticle Tracking Analysis, Rheometry, Size Exclusion Chromatography »

[5 Apr 2016 | ]

How time flies! Spring is here already! Just for you I have collated the latest list of our On Demand webinars. Just click and choose your favorite subject.
I also listed all our upcoming webinars for April. You can register for free and if you can’t attend, we’ll send you the recording few days after the live event so don’t hesitate, click now!
 
March On Demand webinars:

How Size Exclusion Chromatography can improve processes and quality in biopharmaceutical development
Applications of light scattering in pharmaceutical development
Interpretación de resultados de tamaño de partícula por la técnica de difracción …

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Malvern Panalytical Events, Meet the Experts, Nanoparticle Tracking Analysis, Nanosight »

[21 Apr 2015 | ]

Here at Malvern, the NanoSight team is preparing for the International Society of Extracellular Vesicles (ISEV) meeting this week in Washington, D.C. and can’t wait to attend what will be the biggest extracellular vesicle conference to date. The widespread use of NanoSight systems in exosome and microvesicle research makes this one of our best chances to interact closely with users in this application space.  We will have three technical specialists on site to field any questions you have regarding the use of the Nanoparticle Tracking Analysis (NTA) technique for vesicle …

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Dynamic Light Scattering, Malvern Panalytical Events, Meet the Experts, Nanoparticle Tracking Analysis, Nanosight, Particle size, Zeta potential, Zetasizer »

[6 Mar 2015 | ]

Malvern Instruments is heading to Pittcon 2015 this weekend in New Orleans, and while a lot of our time and energy is focused on making sure people get a great experience when visiting our booth (#3,545) or attending our short courses, we’re always keen to see what else is going on in the great conference and networking program. While preparing material for next week, I took a look at the conference program and was excited to see the description of the Wallace H. Coulter lecture that Naomi J. Halas, who …

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