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Raman spectroscopy

Raman spectroscopy is an established spectroscopic technique for measuring the chemical identity and structure of materials across many industries, including pharmaceuticals, fine chemicals, minerals and foods.

Chemical identification, Image Analysis, Laser Diffraction, Malvern Events, Mastersizer, Morphologi G3-ID, Particle shape, Particle size, Raman spectroscopy »

[29 Jun 2016 | ]

Over the past week I’ve had a lot of fun working with Malvern’s team in China to deliver a series of seminars designed to help researchers engaged in pharmaceutical product development. These meetings focused on how Malvern’s material characterization systems can help those developing and manufacturing oral solid dose formulations. During the seminar series, we had the privilege of meeting with well over 200 customers, providing us with the chance to learn about the challenges they are facing in product development, as they seek to select APIs and excipients which …

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Chemical identification, Image Analysis, Laser Diffraction, Mastersizer, Meet the Experts, Morphologi G3-ID, Particle shape, Particle size, Raman spectroscopy, Tech Talk »

[20 Jun 2016 | ]

Component-specific Particle Size
Follow that particle!

I’ve always thought it would be great to be the innocent driver in a movie chase scene who has to respond to the hero’s demand to ‘Follow that car’ as they try to keep tabs on the villain. I always imaged that this would unlock the silent racing driver within me, giving me the excuse to forget about speed limits and drive at the limits of my car’s performance. I’d also get the chance to practice my handbrake turns!
Although I have never been engaged in a …

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Differential Scanning Calorimetry, Electrophoretic light scattering, Isothermal Titration Calorimetry, Label-free analysis, Malvern Events, MicroCal, Microcalorimetry, Molecular structure, Protein Aggregation, Raman spectroscopy, Zetasizer »

[12 May 2016 | ]

I had the pleasure of participating in the 5th International Symposium on Higher Order Structure of Protein Therapeutics, also known as HOS2016, sponsored by CASSS. The meeting was at the Renaissance Hotel in Long Beach, California April 11-13, 2016. I was joined by my Malvern colleagues Rajib Ahmed and David Sanborn.
The HOS Symposium is a platform for open discussion of development and optimization of analytical techniques to study HOS of proteins and biopharmaceutical products (including monoclonal antibodies and antibody-drug conjugates), biocomparability, and biosimilars.
Protein higher order structure (HOS) includes the secondary, …

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Corporate, Malvern Events, Meet the Experts, Raman spectroscopy, Spraytec, Static Light Scattering »

[28 Apr 2016 | ]

You are seriously considering ordering a Zetasizer. An excellent choice! A typical email we often receive at this point is:
“What are the site requirements for the system?”
 
 
The Malvern Zetasizer is a compact benchtop measurement system which requires little space on a standard laboratory lab bench. It also requires connection to a computer (either standard PC or a laptop). All requirements are listed in the manual, which is automatically placed on your computer in PDF format, along with the software and available under
Start –> All Programs –> Malvern Instruments –> Zetasizer Software –> Documentation …

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Image Analysis, Morphologi G3-ID, Particle shape, Particle size, Raman spectroscopy, Tech Talk »

[11 Aug 2015 | ]

When working with a couple of our Morphologi G3-ID cement customers I have come to realize that cement is an incredibly complex product. Working with one of our customers in the cement industry we wrote an article, published last year in International Cement Review, discussing some of the challenges facing the cement industry and how the Morphologi G3-ID can help face these challenges.
Cements can contain a large number of components including any number of additives to adapt the cement behavior, the size and shape of any of these components can …

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Malvern Events, Meet the Experts, Morphologi G3-ID, Particle shape, Particle size, Raman spectroscopy »

[11 Mar 2015 | ]

Hoax bioterrorism powder attacks are well known in the USA. Once it is established that the powder is not a real threat, the search is on to establish who made the hoax threat, and the clues can be right there in the powder itself.  Often artificial sweeteners are used, and whilst bulk Raman analysis can confirm that a powder is dextrose, Morphologically Directed Raman Spectroscopy (MDRS) can help go a step further and identify the specific sweetening agent, and therefore the brand, which may help in the search for the …

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Dynamic Light Scattering, Meet the Experts, Nanoparticle Tracking Analysis, Protein Aggregation, Raman spectroscopy, Resonant mass measurement, Size Exclusion Chromatography, Tech Talk »

[24 Feb 2015 | ]

I recently took part in a question and answer session with BioPharm International about techniques for measuring and characterizing protein aggregates. The full discussion can be viewed here, however I thought I would also use this blog post to summarize the main points.
Essentially, there is a pressing need within the biopharmaceutical industry to understand aggregation pathways, and the risk factors that can induce aggregation, right from the start of the drug development process to align manufacturing processes with Quality by Design (QbD) principles. Given the link between protein aggregation and …

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Dynamic Light Scattering, Meet the Experts, Raman spectroscopy, Tech Talk, Zetasizer »

[17 Dec 2014 | ]

I just got back from participating in the MRS (Materials Research Society) Fall Meeting, which was held in Boston, USA from Nov 30-Dec 5 2014. The MRS meetings are held twice a year and cover a very wide range of topics such as nanomaterials, nanostructured materials, electronic materials, soft matter, energy conversion/storage etc. Advances in materials characterization techniques are also presented and discussed quite extensively including new developments in the area of optofluidics, microfluidics, imaging and spectroscopy.
This year’s fall meeting was attended by several thousand participants and there were in …

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Chemical identification, Customer experience, Morphologi G3-ID, Particle shape, Raman spectroscopy, Tech Talk »

[27 Nov 2014 | ]

Hello!  A few months ago I blogged about my up and coming visit to Australia and I promised to let you know if I made it to the top of the Sydney Harbour bridge – I am not sure where the time as flown to since then but I thought it was about time I let you know how the trip went.
One of the reasons I headed down under was to give 12 seminars; 4 each in Melbourne, Sydney and Brisbane – the team at ATA Scientific did a great …

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Malvern Events, Morphologi G3-ID, Raman spectroscopy, Tech Talk »

[13 Aug 2014 | ]

When I was young, I liked to take things apart to see how they worked. From my dad’s scientific calculators through to my own Scalextric cars and model steam trains, my curiosity always got the better of me as I grappled screwdrivers, pliers and sometimes claw hammers in order to try and find out what was inside. Putting each item back together was never easy though, and often left me with a significant number of ‘spare parts’. Perhaps this experience is why I ended up following a career as a …

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Dynamic Light Scattering, Malvern Events, Raman spectroscopy »

[12 Mar 2014 | ]

More.
Perhaps no other word in the world of analytical instrumentation suggests both opportunity and uncertainty in such nebulous terms.  From a scientist this can be translated as meaning “we’d love to have this capability,” or “this doesn’t do what we need it to do.”  For an instrument manufacturer it can provide a window into the next generation of instrumentation, and present a challenge in how to realize the user’s desires.  Nowhere is this more true than in the rapidly-developing field of large molecule biotherapeutics.
One traditional method for the screening of …

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Morphologi G3-ID, Raman spectroscopy, Tech Talk »

[4 Mar 2014 | ]

Viva la “sameness” – Ensuring Generic Drug Equivalence
Generic drugs make up about 80% of drugs used by US consumers and the percentage of generic drugs used elsewhere around the world is rapidly growing as healthcare costs rise and generic drugs look more and more attractive.  But the challenge for generic drug developers has always been ensuring equivalence to the innovator’s original drug.
Recent reports suggest that there is a $20 million quality evaluation and testing program, involving a dozen academic centers, which is being overseen by the FDA.  This program is …

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Chemical identification, Malvern Events, Morphologi G3, Raman spectroscopy »

[21 Feb 2014 | ]

A new year brings a new job for me as Product Manager for Malvern’s Analytical Imaging range. This brings exciting challenges to think about possible new products and find new applications for our current ones. So that brings me over to Seattle to the American Academy of Forensic Science 66th Annual Scientific Meeting.
On Monday I attended the ‘Applications of Raman Spectroscopy for trace evidence examinations’ workshop chaired by Patrick Buzzini of West Virginia University. There was a really informative introduction to Raman spectroscopy given by Edward M Suzuki which explained …

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Malvern Events, Morphologi G3, Raman spectroscopy »

[15 Oct 2012 | ]
Morphologi G3-ID : Raman spectral libraries?

Another question that quite a few of you asked from the Morphologi G3-ID launch webinar was:
How the instrument uses libraries and what libraries are available?
The answer to the question can really be divided into two sections, the first on how to create and use a library for chemical differentiation, and then secondly how to use third party libraries for chemical identification of unknowns.
Libraries for chemical differentiation
It is a relatively easy task to create libraries from known candidate materials to allow chemical differentiation between particles. This can be done either …

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Malvern Events, Morphologi G3, Particle size, Raman spectroscopy »

[12 Oct 2012 | ]
Morphologi G3-ID : What particle size range can it measure?

Were very happy to see that many hundreds of you tuned in for the Morphologi G3-ID launch last week. There were so many questions that Debbie and myself were unable to answer them all in the time we had – so the Blog comes to the rescue!
One question that was asked by quite a few people was:
Over what particle size range can the Morphologi G3-ID do chemical ID measurements?
The honest answer to this question is that it all depends upon the sample you are looking at and which objective lens …

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Corporate, Meet the Experts, Morphologi G3, Raman spectroscopy »

[11 Oct 2012 | ]
…on with the show

Hello, my name is Chris Jones, as Lisa mentioned in her post, I am a new Technical Specialist for the Vision systems. This includes the FPIA, Morphologi G3 and brand new Morphologi G3-ID which combines the powerful automated imaging of the Morphologi with a Raman spectrometer to provide chemical identity of individual particles. Anyway, enough about the kit, this is about me!
I’ve spent my academic and professional career in imaging and spectroscopy at one energy/length scale or another. My PhD was in Nanoscale physics. I used electrons to image atoms …

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Customer experience, Malvern Events, Meet the Experts, Morphologi G3, Raman spectroscopy »

[9 Oct 2012 | ]
Installation of the first Morphologi G3-ID

Hi, It’s Debbie here again and once more I have been on my travels.
I am thrilled to be able to report we have successfully installed the first Morphologi G3-ID.
My colleague Ben Pattison (Systems Engineer) and I travelled to Zagreb, in Croatia, in the last week of September and installed the system at PLIVA (which is part of the Teva) and provided training to the new users.
The Analytical Imaging team, here at Malvern Instruments, have been building up to this moment for some time and it was great to see the …

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Corporate, Malvern Events, Meet the Experts, Morphologi G3, Particle shape, Particle size, Raman spectroscopy »

[25 Sep 2012 | ]
The show must go on….

I have been involved with the Morphologi G3 products since my return from maternity leave in November 2010.  It has been an interesting return to particle size analysis for me.  In a previous life I was responsible for a pair of PharmaVision 830 instruments, which brought both joy and pain in equal measures.  In comparison, using the Morphologi G3 has tipped that balance well in favor of joy as it has evolved tremendously from its distance ancestor.
The Morphologi G3 has been evolving more recently with the incorporation of a Raman …

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Corporate, Raman spectroscopy »

[4 Sep 2012 | ]
Top tips for giving your baby a head start in the early years

The first three years of life are extremely influential when it comes to a child’s development. Research has shown that there are “critical windows” for different mental abilities, many of which occur during that early developmental period. Once a given brain region has passed that window, the opportunity to “rewire” it is significantly limited.
Nurturing a new drug product through discovery, development and finally to manufacturing is very much the same.  There are “critical windows” during the development process that are important to the evolution of a pharmaceutical with the desired …

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Morphologi G3, Raman spectroscopy »

[2 Feb 2012 | ]
G3-ID: See it! Believe it!

So, for my first blog I thought I’d stick to my area of expertise and – for those of you who didn’t attend the live seminar – summarise this presentation. It included a full demonstration of the instrument in use.
Morphologi G3-ID for component specific particle sizing
Originally presented to global online audiences at the end of last year, my webinar began with an video introducing the G3-ID and covering morphologically directed Raman spectroscopy as delivered by Malvern.
This introduction includes sample preparation and dispersion using pre-defined methods. I then cover a step-by-step …

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