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Taylor Dispersion Analysis

Taylor Dispersion Analysis (TDA) is a microcapillary flow technique that enables solution-based sizing of small molecules, peptides and proteins, and samples with mixtures of these species.

Archimedes, Binding affinity and Kd, Chemical identification, Differential Scanning Calorimetry, Dynamic Light Scattering, Gel permeation chromatography, Image Analysis, Label-free analysis, MicroCal, Microcalorimetry, Morphologi G3-ID, Nanoparticle Tracking Analysis, Nanosight, Particle concentration, Particle shape, Particle size, Protein Aggregation, Raman spectroscopy, Resonant mass measurement, Rheology, Size Exclusion Chromatography, Taylor Dispersion Analysis, Tech Talk, Viscosizer TD, Viscotek, Zetasizer »

[21 Sep 2017 | ]

I know this sounds like the beginning of a bad joke, but in this case, it was actually the beginning of the 2017 Colorado Protein Stability Conference, held in July at Beaver Run Resort in Breckenridge, Colorado. In attendance was a range of scientists and researchers from all over the world, with one common subject in mind: Protein Stability.

One of the highlights of this conference was the pre-conference workshop. This was a free workshop for all attendees of the conference, which was sponsored by Malvern Panalytical. The workshop included a range …

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Differential Scanning Calorimetry, Dynamic Light Scattering, Meet the Experts, MicroCal, Molecular size, Molecular weight, OMNISEC, Particle concentration, Protein Aggregation, Size Exclusion Chromatography, Taylor Dispersion Analysis, Zetasizer »

[18 Jul 2017 | ]

Monoclonal Antibodies – or mAbs for short

Since many of these mAbs require refrigeration we had used dynamic light scattering (with a Zetasizer) to show the formation of aggregates after freeze-thaw cycles (for details see application note “Effect of storage conditions on Immunoglobulin“). These could be seen both in the increased polydispersity index (PDI) and the appearance of a large-size aggregate peak in the intensity size distribution as shown to the right. The area under the peak gives an indication of the presence of the large aggregates but is not suited for …

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Dynamic Light Scattering, Meet the Experts, Taylor Dispersion Analysis, Tech Talk, Viscosizer TD, Zetasizer »

[18 May 2017 | ]

Matt McGann and I will be representing Malvern at the upcoming annual UD Biophysical Characterization Workshop, sponsored by CBST (Center for Biomanufacturing Science & Technology), BITC (Biomolecular Interaction Technologies Center), and the University of Delaware, on June 6, 2017, hosted by Professor Christopher Roberts.
This year’s workshop will consist of three days of short courses and small-group demonstrations of the principles and commercial technologies for characterization of protein solutions and related colloidal systems, focusing specifically on static and dynamic light scattering, electrophoresis (DLS, ELS), and Taylor Dispersion Analysis (TDA).
Matt has been …

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Taylor Dispersion Analysis, Viscosizer TD »

[25 Feb 2016 | ]

I’m reminded of de-sodium-fusion but will avoid this as an opening sentence as it will be understood by but a few chemists……  Ah well, wrong again….
In England, in the early 1800’s, there was a group formed solely for the ‘diffusion of knowledge’.  It was actually more correctly called “The Society for the Diffusion of Useful Knowledge (SDUK) founded in 1826, and wound up in 1848.  The Society published inexpensive texts intended to adapt scientific material for the rapidly expanding reading public. Wikipedia further states “An American group of the same …

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Kinexus, Taylor Dispersion Analysis, Viscosizer TD »

[19 Nov 2015 | ]

Polymer solution rheology to protein aggregation – Following Sir G.I. Taylor
In a very fortuitous way indeed, from my academic research at Bristol University through to my work here at Malvern, I have managed to maintain a connection with the brilliant work of Sir Geoffrey Ingram Taylor (1886-1975) – who has quite rightly been described as ‘one of the most notable scientists of the 20th century’ [1]. It’s quite probable that many workers will have come across some important contribution from Taylor in their line of research, but may not realize that …

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