Electrophoretic light scattering, Meet the Experts, Protein Mobility, Zeta potential, Zetasizer »

[27 Jul 2017 | ]
Isoelectric points of Nanomaterials – Q&A

Nanomaterial isoelectric points IEPs
 
In a recent webinar presented by Ana Morfesis titled “Characterizing the zeta potential & Isoelectric Point of Nanomaterials” we got such a good turnout that we were not able to address the numerous questions asked during the event.
Thank you for the participation!
Since there was such strong interest, we have provided the following list of questions and answers to benefit all who are interested.  We have also provided a table of common metal oxide IEPs, as shown to the left.
 
 
For those who were not able to attend the live event, the session was recorded and is …

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Chemical identification, Image Analysis, Morphologi G3-ID »

[25 Jul 2017 | ]
The science behind ancient Rome’s long-lasting concrete

Why is it that structures built in Roman times have resisted the elements for thousands of years when more modern structures have suffered?
This was a question posed in a recent BBC news story ‘Scientists explain ancient Rome’s long-lasting concrete’ that caught my eye since we have pondered the question here at Malvern before as you can see in this application note “Component Characterization of Cements” where the Morphologi G3-ID was used to study and compare the composition of different cements.

How is the concrete made?
Ancient structures are built using concrete made from …

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[20 Jul 2017 | ]
Solving structure from powder XRD data

As communicated last year, as of 1 January 2017 Malvern Instruments and PANalytical have merged their activities. Both companies are owned by parent company Spectris plc and are world leading suppliers of analytical instrumentation, PANalytical for X-ray instrumentation and software for the purpose of materials analysis, and Malvern Instruments for materials and biophysical characterization technology.
PANalytical’s main technologies are X-ray fluorescence (XRF) and X-ray diffraction (XRD) which provide elemental and structural information on a range of materials across different industry segments and application areas. One such application is solving and understanding crystal structure in crystalline …

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Differential Scanning Calorimetry, Dynamic Light Scattering, Meet the Experts, MicroCal, Molecular size, Molecular weight, OMNISEC, Particle concentration, Protein Aggregation, Size Exclusion Chromatography, Taylor Dispersion Analysis, Zetasizer »

[18 Jul 2017 | ]
Impact of Freeze -Thaw on monoclonal Antibody solutions

Monoclonal Antibodies – or mAbs for short

Since many of these mAbs require refrigeration we had used dynamic light scattering (with a Zetasizer) to show the formation of aggregates after freeze-thaw cycles (for details see application note “Effect of storage conditions on Immunoglobulin“). These could be seen both in the increased polydispersity index (PDI) and the appearance of a large-size aggregate peak in the intensity size distribution as shown to the right. The area under the peak gives an indication of the presence of the large aggregates but is not suited for …

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