Dynamic Light Scattering, Molecular size, Particle concentration, Particle size, Protein Aggregation, Tech Talk, Zetasizer »

[7 Mar 2017 | ]
Can I use DLS for xyz?

How can I use DLS for sample xyz?
What sample concentration / refractive index is needed for reliable DLS size measurements?

Has it been done before?
In Dynamic Light Scattering (DLS) intensity fluctuations in the sample are analyzed to obtain size information on the sample. The technique is applicable to a wide size range from sub-nanometer up to a few microns. In order to obtain a meaningful result, a minimum scattering signal strength must be present. Malvern’s Zetasizer Nano software contains a calculator to help estimate the required minimum concentration.
If anyone else has …

Read the full story »

Differential Scanning Calorimetry, Label-free analysis, Malvern Events, MicroCal, Microcalorimetry, Protein higher order structure »

[1 Mar 2017 | ]
Protein Stability Characterization – the future is here!

The NEW MicroCal PEAQ-DSC – the gold standard for thermal stability determination
Differential scanning calorimetry (DSC) is an established biophysical tool for protein stability characterization during drug development. DSC data are used to advance the most stable and ‘developable’ proteins into the pipeline, and optimize the process and formulation conditions which will maintain protein stability during manufacturing and storage. DSC data are also important in higher order structure (HOS) protein characterization, lot-to-lot comparability, and characterization of biosimilar drugs compared to innovators.
Our previous technology, the MicroCal VP-Capillary DSC Automated system, is a …

Read the full story »

Gel permeation chromatography, Molecular weight, OMNISEC, Size Exclusion Chromatography, Tech Talk »

[23 Feb 2017 | ]
Q&A – OMNISEC for Protein Characterization – Demo at your desk

Recently, I’ve presented a new webinar focusing on the protein characterization using the OMNISEC, the highest quality Gel Permeation Chromatography (GPC) / Size Exclusion Chromatography (SEC) system for the measurement of absolute molecular weight, molecular size, intrinsic viscosity, branching and other parameters. Thank you to all participants for your interest and attention during the webinar.
In this webinar, I highlighted the key features and benefits of the OMNISEC system. How to run samples and analyze data and how to access repeatability of multiple sample measurements.

As usual, after the live section of …

Read the full story »

Malvern Events, Meet the Experts »

[16 Feb 2017 | ]
Malvern Further Education – Tools for Characterization Success

Our goal at Malvern is to make sure our customers achieve the maximum return from their investment in our systems. To ensure that, we are committed to providing the highest quality of application and instrumentation training and support in order to help you conquer your application challenges.
A pioneer in delivering web seminars more than a decade ago, today we provide one the industry’s most active webinar programs with events freely available to customers and non-customers alike. Each year we also offer a variety of in-person seminars and workshops geared toward specific …

Read the full story »