• Do you ever wonder how your Archimedes results compare to the results of other users?
  • Is 20% Relative Standard Deviation (RSD) for repeat measurements good, or maybe not?
  • Are you wondering if you are collecting your data under the best conditions?
  • Are you asking yourself, “Are there enough particles for my results to be statistically meaningful?”
  • What about my sample preparation – is it consistent enough? Could it be affecting my results?

Resonant mass measurement is a relatively new technology. To date, the impact of best practices on measurement results has not been thoroughly explored. To find out more, the Archimedes team at Malvern Panalytical paired up with experts in the Particle Characterization Core Facility at KBI Biopharma, Inc and Professor John Carpenter’s lab at the University of Colorado’s Skagg’s School of Pharmacy and Pharmaceutical Sciences.


In a recent study, the collaborative team developed a set of best practices for resonant mass measurement using a model protein system. The effects on the repeatability and reproducibility of particle measurements of adhering to a set of rigorously-controlled operating conditions were tested at each of the three collaborating sites.

Read our article in the Journal of Pharmaceutical Sciences to see the results!

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