Author Archives: Verna Frasca

Verna Frasca received her Ph.D. in Biological Chemistry from the University of Michigan, and did post-doctoral training at New York State Department of Health (Albany) and University of Texas Southwestern Medical Center (Dallas). Dr. Frasca is joined MicroCal in 2001, and is currently the Applications Manager for MicroCal products with Malvern Instruments. Her responsibilities include supporting use of Isothermal Titration Calorimetry (ITC) and Differential Scanning Calorimetry (DSC) in the life sciences and drug discovery and development. Dr. Frasca has extensive experience in protein expression, protein purification, enzymology, biophysical characterization, and molecular biology.

Published 22 Sep 2020

Advances in Microcalorimetry 2020 is now virtual!

In February, I posted a blog announcing our 2020 Advances in Microcalorimetry meeting. That seems like seven years ago, not seven months. Like many other organizations, we are not able to host live conferences. Even though there is no replacement for a live meeting,…READ MORE >

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Published 28 Jul 2020

ITC Technical Tip: Merging ITC data files by concatenation

Concatenation (noun) con·cat·e·na·tion plural concatenations Definition of concatenation: a group of things linked together or occurring together in a way that produces a particular result or effect the act of concatenating things or the state of being concatenated : union…READ MORE >

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Published 23 Jun 2020

MicroCal PEAQ-ITC with organic solvents: Tips and cautions

Tips on performing experiments with organic solvents on a MicroCal PEAQ-ITC system, including experimental method adjustment for organic solvents.

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Published 28 May 2020

How to shut down MicroCal instruments for extended storage

When your MicroCal system will not be used for an extended period, these are the recommended procedures for the shutdown of different MicroCal instruments.

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Published 23 Apr 2020

WEBINAR Focus on Pharma – Characterization of Human Soluble Epoxide Hydrolase Kinetics by ITC

Join us on May 14 for a webinar about Isothermal Titration Calorimetry, presented by Professor Conte and Dr. Abis from Kings College, London.

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Published 14 Apr 2020

Summary of Styrene Maleic Acid-lipid particles (SMALP) 2020 conference

Styrene maleic acid-lipid particles (SMALPs) are nanodiscs made from the interaction of membrane bilayers and styrene-maleic acid (SMA) copolymer. SMA and other related amphipathic polymers can spontaneously solubilize membranes to form SMALPs. Since there is no requirement for the conventional detergents…READ MORE >

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Published 4 Feb 2020

Save the date: “Advances in Microcalorimetry 2020” – Join us in Bethesda, Maryland this October

Are you: Interested in finding out more about microcalorimetry and how you can apply these tools to advance your biomolecular characterization studies during drug discovery, drug development, or life science research? A new user of Isothermal Titration Calorimetry (ITC) or…READ MORE >

Published 13 Nov 2019

What’s new in ITC: Additions to your (virtual) bookshelf

Use of Isothermal Titration Calorimetry (ITC) continues to grow, and many books and scientific articles cite the use of Malvern Panalytical’s MicroCal ITC systems. This blog highlights recent publications. You can easily use Google Scholar or Scopus to find other…READ MORE >

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Published 18 Apr 2019

Best Practices for Isothermal Titration Calorimetry to study binding interactions – Part 4

Here are several best practices for performing traditional binding experiments with the MicroCal PEAQ-ITC, VP-ITC and iTC200 systems. This is a continuation of previous blogs ‘Best Practices for Isothermal Titration Calorimetry to study binding interactions’ part 1, part 2 and…READ MORE >

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