Microcalorimetry


Characterizing the interactions and stability of biomolecules.

Microcalorimetry is used to study reactions involving biomolecules, including interactions between molecules and conformational changes such as protein folding. Applications range from confirming intended binding targets in small molecule drug discovery to the development of stable biotherapeutics.

Published 22 Sep 2020

Advances in Microcalorimetry 2020 is now virtual!

In February, I posted a blog announcing our 2020 Advances in Microcalorimetry meeting. That seems like seven years ago, not seven months. Like many other organizations, we are not able to host live conferences. Even though there is no replacement for a live meeting,…READ MORE >

Tags: , , , ,

Published 25 Aug 2020

DSC and protein stability: What does the enthalpy change mean?

DSC is the only analytical method that measures enthalpy change (∆H) of thermal transition directly. For protein, this is energy (heat) spent to unfold it.

Tags: , , , ,

Published 28 Jul 2020

ITC Technical Tip: Merging ITC data files by concatenation

Concatenation (noun) con·cat·e·na·tion plural concatenations Definition of concatenation: a group of things linked together or occurring together in a way that produces a particular result or effect the act of concatenating things or the state of being concatenated : union…READ MORE >

Tags: , , ,

Published 8 Jul 2020

How Lucky Am I?

I work at an organization that is behaving with absolute fairness and integrity throughout the pandemic. I have colleagues who have kept our site open, in a safe way, to continue serving our customers. I owe a particularly big ‘Thank…READ MORE >

Tags: ,

Published 23 Jun 2020

MicroCal PEAQ-ITC with organic solvents: Tips and cautions

Tips on performing experiments with organic solvents on a MicroCal PEAQ-ITC system, including experimental method adjustment for organic solvents.

Tags: , , ,

Published 23 Apr 2020

WEBINAR Focus on Pharma – Characterization of Human Soluble Epoxide Hydrolase Kinetics by ITC

Join us on May 14 for a webinar about Isothermal Titration Calorimetry, presented by Professor Conte and Dr. Abis from Kings College, London.

Tags: , ,

Published 11 Feb 2020

SLAS 2020 – How lucky am I?

As a product manager for a range of instruments that serve the drug discovery market, it was a ‘must’ for me to go to San Diego, in January, to attend SLAS2020. It was 40°F warmer than in Massachusetts (where I…READ MORE >

Tags: ,

Published 4 Feb 2020

Save the date: “Advances in Microcalorimetry 2020” – Join us in Bethesda, Maryland this October

Are you: Interested in finding out more about microcalorimetry and how you can apply these tools to advance your biomolecular characterization studies during drug discovery, drug development, or life science research? A new user of Isothermal Titration Calorimetry (ITC) or…READ MORE >

Published 13 Nov 2019

What’s new in ITC: Additions to your (virtual) bookshelf

Use of Isothermal Titration Calorimetry (ITC) continues to grow, and many books and scientific articles cite the use of Malvern Panalytical’s MicroCal ITC systems. This blog highlights recent publications. You can easily use Google Scholar or Scopus to find other…READ MORE >

Tags: , , , ,

Subscribe Now