Microcalorimetry


Characterizing the interactions and stability of biomolecules.

Microcalorimetry is used to study reactions involving biomolecules, including interactions between molecules and conformational changes such as protein folding. Applications range from confirming intended binding targets in small molecule drug discovery to the development of stable biotherapeutics.

Published 22 Sep 2020

Advances in Microcalorimetry 2020 is now virtual!

In February, I posted a blog announcing our 2020 Advances in Microcalorimetry meeting. That seems like seven years ago, not seven months. Like many other organizations, we are not able to host live conferences. Even though there is no replacement for a live meeting,…READ MORE >

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Published 25 Aug 2020

DSC and protein stability: What does the enthalpy change mean?

DSC is the only analytical method that measures enthalpy change (∆H) of thermal transition directly. For protein, this is energy (heat) spent to unfold it.

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Published 28 Jul 2020

ITC Technical Tip: Merging ITC data files by concatenation

Concatenation (noun) con·cat·e·na·tion plural concatenations Definition of concatenation: a group of things linked together or occurring together in a way that produces a particular result or effect the act of concatenating things or the state of being concatenated : union…READ MORE >

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Published 8 Jul 2020

How Lucky Am I?

I work at an organization that is behaving with absolute fairness and integrity throughout the pandemic. I have colleagues who have kept our site open, in a safe way, to continue serving our customers. I owe a particularly big ‘Thank…READ MORE >

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Published 23 Jun 2020

MicroCal PEAQ-ITC with organic solvents: Tips and cautions

Tips on performing experiments with organic solvents on a MicroCal PEAQ-ITC system, including experimental method adjustment for organic solvents.

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