Microcalorimetry


Characterizing the interactions and stability of biomolecules.

Microcalorimetry is used to study reactions involving biomolecules, including interactions between molecules and conformational changes such as protein folding. Applications range from confirming intended binding targets in small molecule drug discovery to the development of stable biotherapeutics.

Published 10 Jan 2019

Best Practices for ITC to study binding interactions – Part 1

Here are several best practices for performing traditional binding experiments with the MicroCal PEAQ-ITC, VP-ITC and ITC200 systems.    Sample requirements: By convention, the “Macromolecule” is the biomolecule in the isothermal titration calorimeters (ITC) cell, and the “ligand” is the biomolecule…READ MORE >

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Published 8 Jan 2019

Don’t miss your chance to meet protein and particle experts!

The New Year brings a unique opportunity for interaction with key opinion leaders at Malvern Panalytical’s free-to-attend Symposium on Biophysical and Particle Characterization, taking place at Medimmune Cambridge, UK, on February 19th. Please take a look at the event page…READ MORE >

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Published 19 Oct 2018

Overcoming Characterization Challenges in Drug Formulation – Q&A

On October 2, 2018, we held a seminar entitled “Overcoming Characterization Challenges in Drug Formulation” in the Boston area.  It was a great opportunity to meet with many pharmaceutical scientists in the area and learn about their challenges and concerns. …READ MORE >

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Published 13 Jun 2018

3rd European MicroCal meeting – Join us in London this September for 2 days of analytical bioscience!

The time is fast arriving for the third in our highly successful series of European MicroCal meetings! This year the meeting is organized by Malvern Panalytical alongside a Scientific Committee of expert users from academia and industry, all with the support of…READ MORE >

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Published 12 Oct 2017

Isothermal Titration Calorimetry – A hot characterization tool for biomolecular interactions

Isothermal Titration Calorimetry Molecular recognition is key in all biological processes and cellular responses. It is critical to characterize the structural and thermodynamic forces behind the recognition and specificity of macromolecular interactions in order to understand the molecular events in a…READ MORE >

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