Microcalorimetry


Characterizing the interactions and stability of biomolecules.

Microcalorimetry is used to study reactions involving biomolecules, including interactions between molecules and conformational changes such as protein folding. Applications range from confirming intended binding targets in small molecule drug discovery to the development of stable biotherapeutics.

Published 8 Jun 2021

Viral Vector Vaccines: A Borrowed Technology from Gene Therapy Advancements

Advances in recombinant DNA technology, genomics, and immunology have greatly influenced the vaccine development process. The genetic manipulation of viruses makes them suitable as vectors for gene delivery, providing a novel and unique opportunity for vaccine design. Viruses survive and…READ MORE >

Tags: , , , ,

Published 20 May 2021

Calories to Cures

Early commercially available biological calorimeters developed in the ’70s were initially used to study the “protein folding” question as part of the drive to design proteins de novo.  Differential scanning calorimetry (DSC) in more recent years has found its niche…READ MORE >

Tags: , , , ,

Published 13 May 2021

Delving Deeper into AAV Attributes

Adeno-associated viruses (AAVs) have recently gained a lot of interest in gene therapy research for delivering modified genes into target cells to treat or prevent a disease by replacing a mutated gene with a healthy copy of the gene. Recombinant…READ MORE >

Published 28 Apr 2021

Our role in advancing global SARS-CoV-2 vaccine research

With 7 different Covid-19 vaccines now publicly available and ~1 billion doses having been administered, now is a good time for an interim review of how Malvern Panalytical has been able to support these developments. We are proud to share…READ MORE >

Tags: , , , ,

Published 31 Mar 2021

Liposomes: A 3-Part Tale!

Liposomes are attractive vehicles for drug payload delivery, among other nanoparticles helping to provide endless possibilities for tackling various pharmaceutical needs.  We provide solutions for the effective and optimal development of liposomes and other nanoparticles, which help ensure that only…READ MORE >

Tags: , ,

Published 9 Mar 2021

Unleash the potential of antibody drug conjugates

Join us for our March 31 webinar on ADC synthesis and characterization strategies. Jamie Stokes and Muneera Beach will provide useful tools for accelerating your ADC projects. You will also learn how Concept Life Sciences and Malvern Panalytical help with…READ MORE >

Tags: , , , ,

Published 22 Sep 2020

Advances in Microcalorimetry 2020 is now virtual!

In February, I posted a blog announcing our 2020 Advances in Microcalorimetry meeting. That seems like seven years ago, not seven months. Like many other organizations, we are not able to host live conferences. Even though there is no replacement for a live meeting,…READ MORE >

Tags: , , , ,

Published 25 Aug 2020

DSC and protein stability: What does the enthalpy change mean?

DSC is the only analytical method that measures enthalpy change (∆H) of thermal transition directly. For protein, this is energy (heat) spent to unfold it.

Tags: , , , ,

Published 28 Jul 2020

ITC Technical Tip: Merging ITC data files by concatenation

Concatenation (noun) con·cat·e·na·tion plural concatenations Definition of concatenation: a group of things linked together or occurring together in a way that produces a particular result or effect the act of concatenating things or the state of being concatenated : union…READ MORE >

Tags: , , ,

Subscribe Now