Size Exclusion Chromatography (SEC)


Size Exclusion Chromatography (SEC or SEC-HPLC) is an analytical technique that separates dissolved macromolecules by size based on their elution from columns filled with a porous gel.

Published 7 Oct 2021

GPC/SEC standards: making them last

Earlier this year I highlighted the different types of GPC/SEC standards available and where to find them on our eStore. In this post, I’m going to share some tips and tricks about preparing your standards and making them last. But…READ MORE >

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Published 29 Sep 2021

Waters and Malvern Panalytical Partner for Complete High-Resolution Polymer Characterization

On November 2nd, Waters and Malvern Panalytical is co-hosting a webinar: “Unlocking Polymers in Medical Devices: Combining High-Resolution Separations from the Waters ACQUITY APC and Advanced Detectors from the Malvern Panalytical OMNISEC REVEAL“ co-presented by Larry Meeker (Waters, Application Scientist)…READ MORE >

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Published 9 Sep 2021

SEC-MALS 20: upgrade your system!

I spill a lot of digital ink extolling the virtues of our OMNISEC system, and for good reason!  The power of a complete, advanced detection SEC system is undeniable.  But in this post, I’m going to focus on a single,…READ MORE >

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Published 18 Aug 2021

Ask an Expert: Dive deeper into multi-detection OMNISEC samples analysis

If only I asked an expert earlier… Sometime before I joined Malvern Panalytical, my Gel Permeation Chromatography (GPC) knowledge level was quite low. When I was using a GPC system to analyze the polymers, synthesizing it wasn’t a cerebral process….READ MORE >

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Published 7 Jul 2021

OMNISEC consumables on the eStore!

A GPC/SEC system contains a lot of parts!  In addition to columns and standards, there are a number of consumable items required to actually use the instrument.  Since I didn’t get to them in my last post, this one will…READ MORE >

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Published 10 Jun 2021

The importance of the post-column filter

I began this post with the intention of discussing the most popular GPC/SEC consumables available from the Malvern Panalytical eStore.  As with my previous posts on columns and standards, my goal was to provide a list of consumables to keep…READ MORE >

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Published 8 Jun 2021

Viral Vector Vaccines: A Borrowed Technology from Gene Therapy Advancements

Advances in recombinant DNA technology, genomics, and immunology have greatly influenced the vaccine development process. The genetic manipulation of viruses makes them suitable as vectors for gene delivery, providing a novel and unique opportunity for vaccine design. Viruses survive and…READ MORE >

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Published 6 May 2021

Aggregates! And what they look like in GPC/SEC data

One of the pleasures of working in the Applications Lab is that I get to analyze a variety of GPC/SEC sample types.  I can be finishing up a set of biodegradable polyesters, currently running low molecular weight oligomers, while getting…READ MORE >

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Published 26 Apr 2021

Compositional analysis! Now with OMNISEC

In a previous post, I described how you can determine the composition of a sample through GPC/SEC analysis. This powerful method has found many applications, with a recent example being AAV characterization. With these types of analyses becoming increasingly popular,…READ MORE >

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