Size Exclusion Chromatography (SEC)


Size Exclusion Chromatography (SEC or SEC-HPLC) is an analytical technique that separates dissolved macromolecules by size based on their elution from columns filled with a porous gel.

Published 6 May 2021

Aggregates! And what they look like in GPC/SEC data

One of the pleasures of working in the Applications Lab is that I get to analyze a variety of GPC/SEC sample types.  I can be finishing up a set of biodegradable polyesters, currently running low molecular weight oligomers, while getting…READ MORE >

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Published 26 Apr 2021

Compositional analysis! Now with OMNISEC

In a previous post, I described how the composition of a sample can be determined through GPC/SEC analysis. This powerful method has found many applications, with a recent example being AAV characterization. With these types of analyses becoming increasingly popular,…READ MORE >

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Published 20 Apr 2021

What can compositional analysis do for me?

A few days ago, my colleague Dr. John Stenson previewed the upcoming launch of the OMNISEC software’s newest feature: compositional analysis!  Amidst your excitement at the great content headed your way, you might be wondering, “what can compositional analysis do…READ MORE >

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Published 14 Apr 2021

OMNISEC is getting an upgrade!

I always find it incredibly exciting to talk about new features and functionality that we have created for our systems… and this time is no different! I understand that systems need to be continually improved and expanded to meet our…READ MORE >

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Published 31 Mar 2021

Liposomes: A 3-Part Tale!

Liposomes are attractive vehicles for drug payload delivery, among other nanoparticles helping to provide endless possibilities for tackling various pharmaceutical needs.  We provide solutions for the effective and optimal development of liposomes and other nanoparticles, which help ensure that only…READ MORE >

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Published 10 Mar 2021

GPC/SEC standards from the eStore!

In my last post, I highlighted the most common GPC/SEC columns available from the Malvern Panalytical eStore.  Just like with columns, scientists rely on the selection of appropriate GPC/SEC standards to generate reliable methods and obtain quality results.  In order…READ MORE >

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Published 9 Mar 2021

Unleash the potential of antibody drug conjugates

Join us for our March 31 webinar on ADC synthesis and characterization strategies. Jamie Stokes and Muneera Beach will provide useful tools for accelerating your ADC projects. You will also learn how Concept Life Sciences and Malvern Panalytical help with…READ MORE >

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Published 1 Mar 2021

Pittcon Short Courses 2021 still open for registration

This year’s Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy (or Pittcon for short) is taking place Online, from March 8 – March 12, 2021. As in previous years, there is a large selection of Pittcon short courses 2021 relevant…READ MORE >

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Published 9 Feb 2021

GPC/SEC columns from the eStore!

Columns and standards are an essential part of every GPC/SEC analysis.  To obtain quality data, scientists depend on the selection of appropriate columns and standards specific to their application.  In order to accommodate a diverse range of applications, Malvern Panalytical…READ MORE >

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