Tag Archives: Binding interactions


Published 15 Sep 2021

Ask an Expert: Microcalorimetry

A versatile tool for the characterization of biomolecular interactions Isothermal titration microcalorimetry (ITC) is widely used in the life sciences and is an essential tool in drug discovery and the study and regulation of protein interactions. It measures the binding…READ MORE >

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Published 29 Jan 2019

First Virtual Malvern Panalytical MicroCal ITC User Meeting – February 28th, 12-3pm ET!

Following our recent successful virtual Zetasizer User meeting back in October 2018, we are pleased to announce the first MicroCal Isothermal Titration (ITC) Virtual User Meeting – Thursday, February 28, 2019, 12:00 to 3:00 PM Eastern Time (ET). This initiative…READ MORE >

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Published 10 Jan 2019

Best Practices for Isothermal Titration Calorimetry to study binding interactions – Part 1

Here are several best practices for performing traditional binding experiments with the MicroCal PEAQ-ITC, VP-ITC and ITC200 systems.    Sample requirements: By convention, the “Macromolecule” is the biomolecule in the isothermal titration calorimeters (ITC) cell, and the “ligand” is the biomolecule…READ MORE >

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