Published 29 Jan 2019
Following our recent successful virtual Zetasizer User meeting back in October 2018, we are pleased to announce the first MicroCal Isothermal Titration (ITC) Virtual User Meeting – Thursday, February 28, 2019, 12:00 to 3:00 PM Eastern Time (ET). This initiative…READ MORE >
Tags: Binding interactions, isothermal titration calorimetry, ITC, MicroCal
Published 5 Jul 2018
Isothermal Titration Calorimetry (ITC) is considered the ‘gold standard’ biophysical assay to determine the binding affinity/dissociation constant for any interaction involving proteins, nucleic acids, or lipids. ITC also determines the binding stoichiometry (related to the number of binding sites), and…READ MORE >
Tags: citations, Google Scholar, isothermal titration calorimetry
Published 7 May 2015
During May & June we’re running a series of free seminars in the USA and Canada for people who want to learn more about the latest methods for nanoparticle characterization. The seminars will each last 1.5 days, giving you the…READ MORE >
Tags: differential scanning calorimetry, dynamic light scattering, gel permeation chromatography, isothermal titration calorimetry, MicroCal
Published 23 Apr 2015
Don’t throw away your “bad” N-value ITC data The N-value commonly referred as the stoichiometry is often used as a qualifier for a “good” or “bad” titration. The reasoning goes like this – “if my N-value is 20% or more…READ MORE >
Tags: dH, isothermal titration calorimetry, ITC, Kd, N-value
Published 15 Apr 2015
We are offering four very exciting life science seminars in the Netherlands this month and the best part is that there is no charge to attend. There are several options depending on your specific area of interest, covering advanced training…READ MORE >
Tags: differential scanning calorimetry, DSC, dynamic light scattering, Events, isothermal titration calorimetry
Published 26 Feb 2015
1977 was a memorable year for many reasons – the first Apple II computers went on sale, the first MRI Scanner was tested, and for many the stand out event was the release of the first Star Wars movie. What…READ MORE >
Tags: binding, binding mechanisms, biomolecular, drug discovery, heat values
Published 21 Oct 2014
Over production of certain proteins that control cellular responses in the body can lead to unregulated events, including various cancers. Proteins linked to tumor growth, known as oncoproteins, can be extremely difficult to inhibit by known small molecule drugs, owing…READ MORE >
Tags: cancer, differential scanning calorimetry, drug development, drug discovery, DSC
Published 28 Jul 2014
Our portfolio of instruments to aid in biopharmaceutical research has grown significantly in recent years, thanks to innovation from our Bioscience Development Initiative as well as acquisitions of NanoSight, Viscotek and most recently, MicroCal. As a result,the amount of useful…READ MORE >
Tags: biotherapeutic, Calorimetry, DLS, forumulation stability, isothermal titration calorimetry