Tag Archives: polydispersity


Published 31 May 2018

Polydispersity from a Gold Standard

How good can a gold standard be?   When performing dynamic light scattering (DLS) measurements, we sometimes encounter especially nice data. An interesting issue to consider is the level of data quality one can expect to achieve. What is the…READ MORE >

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Published 23 Oct 2017

Polydispersity – what does it mean for DLS and chromatography?

The term polydispersity (or more recently dispersity without the poly, as per IUPAC recommendation) is used to describe the degree of “non-uniformity” of a distribution.  In the field of molecular/nanoparticular characterization, there are in principle two different definitions of polydispersity,…READ MORE >

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Published 31 Mar 2015

PDI from an individual peak in DLS

Can one calculate a PDI value excluding a small aggregation peak? For example if the main particle species is ~100nm and there is a small contribution (2% by intensity) from a peak at 5 microns, is it possible to recalculate…READ MORE >

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Published 2 Jan 2014

The Chromatogram Series: Sodium Hyaluronate / Hyaluronan

When Pete Townshend wrote “I hope I die before I get old” back in 1965’s “My Generation,” the Who guitarist was almost certainly taking an anti-establishment stance rather than fretting about future health issues. Fortunately for music fans, Mr. Townshend…READ MORE >

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Published 10 Dec 2013

The Chromatogram Series: Hydroxylpropyl Cellulose HPC

December-2013. It is the season to be jolly. Charles Dickens once wrote “we need never be ashamed of our tears” (in his ‘Great Expectations’).  This, of course, presumes that we have sufficient tears in the first place.  For the unfortunate…READ MORE >

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