Published 7 May 2015
During May & June we’re running a series of free seminars in the USA and Canada for people who want to learn more about the latest methods for nanoparticle characterization. The seminars will each last 1.5 days, giving you the…READ MORE >
Tags: differential scanning calorimetry, dynamic light scattering, gel permeation chromatography, isothermal titration calorimetry, MicroCal
Published 24 Feb 2015
I recently took part in a question and answer session with BioPharm International about techniques for measuring and characterizing protein aggregates. The full discussion can be viewed here, however I thought I would also use this blog post to summarize…READ MORE >
Tags: buoyant mass, dynamic light scattering, FDA, morphologi G3-ID, Nanoparticle Tracking Analysis
Published 9 Dec 2014
Recently this question was posed where a current dynamic light scattering (DLS) user inquired about detecting large but subvisible particles in a formulation: “I have been looking at solutions from prefilled syringes which appear in flow microscopy to have significant…READ MORE >
Tags: DLS, dynamic light scattering, QA/QC, quality control, Resonant Mass Measurement
Published 5 Nov 2014
Having spent more than twenty years in the instrumentation arena and worked with a variety of different characterization techniques in lots of different application spaces, I have sometimes struggled to explain to my family what it is that I do. Particularly to…READ MORE >
Tags: DLS, dynamic light scattering, nanobubble, nanobubbles, Nanoparticle Tracking Analysis
Published 24 Sep 2014
There aren’t many things more pleasurable than a warm summer’s day in the Malvern Hills, but when you find out the mid-term meeting for your project is being held in Barcelona, it’s very difficult to be disappointed! Obviously Barcelona was…READ MORE >
Tags: Nanoclusters, nanoparticle clusters, nanoparticles, Resonant Mass Measurement, UNION project
Published 2 Sep 2014
PhD student Polly came into the lab on Monday morning to find that her purified protein had started to aggregate after a weekend in the fridge. The profile she got from her Dynamic Light Scattering (DLS) measurement clearly showed two…READ MORE >
Tags: DLS, dynamic light scattering, Nanoparticle Tracking Analysis, nanosight, NTA
Published 24 Jul 2014
Thank you to everyone who joined us on 26th June, for the webinar “Protein Aggregation – Bridging the SubMicron Gap.” We held this webinar because we know that the formation of protein aggregates is a particular concern for parenteral administration biopharmaceuticals due…READ MORE >
Tags: mass, Particle size, protein aggregation, Resonant Mass Measurement, subvisible particles
Published 22 Jul 2014
Last week I attended the 4th Microbubble Symposium hosted by the Leeds Microbubble Consortium at University of Leeds in the UK. The meeting focused on the Fabrication, Characterization and Translational Applications of Microbubbles. I went along to hear about the…READ MORE >
Tags: Leeds Microbubble Consortium, Microbubble, Microbubble Symposium, microbubbles, nanobubble
Published 29 Nov 2012
At Malvern, the launch of a new product is always an exciting time. With our stated goals of growing into the biopharmaceutical market to satisfy their development needs, the launch of a product to help us achieve this goal is…READ MORE >
Tags: dynamic light scattering, molecular weight, proteins, Resonant Mass Measurement, size exclusion chromatography