Tag Archives: sec-mals


Published 25 Sep 2019

Rh or Rg: Which is best for my GPC/SEC samples?

The primary goal when employing gel permeation / size exclusion chromatography (GPC/SEC) is often to determine the molecular weight of a macromolecular sample.  Multi-detector systems, such as Malvern Panalytical’s OMNISEC and TDAmax systems, are able to offer a range of…READ MORE >

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Published 13 Aug 2019

Can my GPC/SEC chromatogram be trusted?

You’ve done the hard parts to get your GPC/SEC instrument ready: prepared the mobile phase, stabilized the detector baselines, and prepared your sample.  After injection and completion of your sample sequence, you have acquired data.  Congrats!  Now, before you even…READ MORE >

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Published 19 Sep 2018

Which light scattering detector is best for me?

Determining which gel permeation/size exclusion chromatography (GPC/SEC) system is best for your needs can be a daunting task. Even after you’ve decided to include a light scattering detector to obtain absolute molecular weight data you’re still left to choose between…READ MORE >

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Published 22 Aug 2018

What is a dn/dc value and why is it important for GPC/SEC?

The most common detector in any GPC/SEC instrument is a refractive index (RI) detector.  There are multiple reasons for this, but the most important is because the difference in refractive index between that of a sample solution and that of…READ MORE >

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Published 24 Jul 2018

Why does my viscometer signal have a negative peak?

If you’ve ever analyzed GPC/SEC data collected on your OMNISEC or TDA 305 instrument that included a viscometer detector, you might have observed and wondered about a negative peak that elutes in the viscometer signal long after the sample peak. …READ MORE >

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